Search by individual drug
*The Area Prescribing Committee may accept shared care guidelines that have been produced by other organisations.
| Drug | Indications | Drug class | APC Date or Other (n) = New (a) = Amendment |
|---|---|---|---|
| 3,4-diaminopyridine | Lambert-Eaton myasthenic syndrome (LEMS) (commissioned by NHS England) | Red | |
| 5-methoxypsoralen | PUVA treatment of psoriasis | Red | |
| Abacavir | HIV infection (commissioned by NHS England) | Red | |
| Abacavir/dolutegravir/lamivudine | HIV infection (commissioned by NHS England) | Red | |
| Abacavir/lamivudine | HIV infection (commissioned by NHS England) | Red | |
| Abaloparatide | Male and juvenile osteoporosis (NHS England) | Red | |
| Abatacept | All indications | Red | |
| Abemaciclib | Treatment of cancer (commissioned by NHS England) | Red | 31st July 2019 (n) |
| Abiraterone | Treatment of cancer (commissioned by NHS England) | Red | |
| Acamprosate | Maintain abstinence in alcohol-dependent patients | Amber | |
| Acetylcysteine sachets | Intestinal obstruction | Green Specialist Initiation | |
| Acetylcysteine | Interstitial lung disease | Green Specialist Initiation | |
| Acetylcysteine | Red for newly diagnosed patients with cystic fibrosis (CF) | Red | |
| Acetylcysteine | COPD | Green | 31st July 2019 (n) |
| Acitretin | Oral retinoid for psoriasis | Red | |
| Aclidinium bromide powder inhaler | Chronic obstructive pulmonary disease (COPD) | Green | |
| Actipatch® | Pain | Black not yet classified | |
| Adalimumab | All indications | Red | |
| Adefovir | Hepatitis B (commissioned by NHS England) | Red | |
| Afatinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Aflibercept | All indications | Red | |
| Agalsidase alfa | Fabry's disease (commissioned by NHS England) | Red | |
| Agalsidase beta | Fabry's disease (commissioned by NHS England) | Red | |
| Agomelatine | Antidepressant (amber for existing patients) | Red for new patients. Amber | |
| Albumin-bound paclitaxel | Treatment of cancer (commissioned by NHS England) | Red | |
| Albutropin | Adult onset growth hormone deficiency (NHS England) | Red | |
| Aldesleukin | Treatment of cancers (NHS England) | Red | |
| Alectinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Alemtuzumab | All indications | Red | |
| Alglucosidase alfa | Pompe disease (commissioned by NHS England) | Red | |
| Alipogene tiparvovec | Lipoprotein lipase deficiency (NHS England) | Red | |
| Aliskiren | Stage 4 hypertension | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Alisporivir | Hepatitis C (commissioned by NHS England) | Red | |
| Alitretinoin | Severe chronic hand eczema refractory to potent topical corticosteroids | Red | |
| Alogliptin | Type 2 diabetes (T2DM) | Green | |
| Alpha-1 antitrypsin | Alpha-1 antitrypsin deficiency | Red | |
| Alpha mannosidase recombinant human | Alpha mannosidase deficiency (NHS England) | Red | |
| Alprostadil cream | Erectile Dysfunction | Green Specialist Initiation | 18th March 2020 (n) |
| Alteplase | Thrombolytic | Red | |
| Ambrisentan | Pulmonary arterial hypertension (commissioned by NHS England) | Red | |
| Amiodarone | Treatment of Ventricular and Supraventricular Arrhythmias for Adult Patients | Amber LTHT | 18th March 2020 (n) |
| Amifampridine | Lambert-Eaton myasthenic syndrome (LEMS) (NHS England) | Red | |
| Amikacin inhalation | Cystic fibrosis (CF) | Red | |
| Amikacin liposomal | Cystic fibrosis (CF) | Red | |
| Amphotericin liposomal | Fungal infections | Red | |
| Amisulpride | Atypical antipsychotic for schizophrenia | Green Specialist Initiation | |
| Anabasam | Scleroderma | Red | |
| Anagrelide | Essential thrombocythaemia | Red | |
| Anakinra | All indications | Red | |
| Anastrozole | Breast Cancer - long term therapy | Green Specialist Initiation | |
| Anidulafungin | IV antifungal agent | Red | |
| Anifrolumab | Systemic lupus erythematosus (SLE) | Red | |
| Anoro Ellipta 55/22® | Chronic obstructive pulmonary disease (COPD) | Green | |
| Anti-epileptic drugs (AED) in children | See LTHT guidance for information | Green Specialist Initiation | |
| Antihistamines for hay fever (OTC or prescription) | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Antihaemophilic factor/Von Willebrand factor complex | As per BCSH guidelines for specialised indications | Red | |
| Antilymphocyte globulin | Aplastic anaemia organ transplant | Red | |
| Antipseudomonas aeruginosa IgY | Cystic fibrosis (CF) | Red | |
| Antithrombin III | As per BCSH guidelines for specialised indications | Red | |
| Antithymocyte immunoglobulin | Aplastic anaemia organ transplant | Red | |
| Anti-retrovirals | HIV infection (commissioned by NHS England) | Red | |
| Antox® | Anti-oxidant therapy for pancreatitis | Green Specialist Initiation | |
| Apixaban | See DOACs | See DOACs | |
| Apomorphine | Parkinson's disease | Green Specialist Initiation | |
| Apremilast | According to NICE (TA433) for the treatment of active psoriatic arthritis & (TA419) for treating moderate to severe plaque psoriasis | Red | |
| Apremilast | Paediatric indications | Red | |
| Aprepitant | Nausea/vomiting with highly emetogenic chemotherapy | Red | |
| Aragam® | All indications | Red | |
| Arimoclomol | Niemann-Pick disease | Red | |
| Aripiprazole (oral) | Schizophrenia | Green Specialist Initiation | 31st July 2019 (a) |
| Aripiprazole injection | Schizophrenia | Red | 31st July 2019 (n) |
| Arsenic trioxide | Treatment of cancer (commissioned by NHS England) | Red | |
| Artesunate | Treatment of severe malaria | Red | 22nd January 2020 |
| Asenapine | Treatment of bipolar disorders | Red | |
| Asfotase alfa | Hypophosphatasia | Red | |
| Asunaprevir with daclatasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Atacicept | Systemic lupus erythematosus (SLE) | Red | |
| Ataluren | Duchenne muscular dystrophy | Red | |
| Atazanavir | HIV infection (commissioned by NHS England) | Red | |
| Atazanavir/cobicistat | HIV infection (commissioned by NHS England) | Red | |
| Atezolizumab | Treatment of cancer (commissioned by NHS England) | Red | |
| Autologous chrondocyte implantation | Articular cartilage defect | Red | |
| Autologous serum eye drops | Dry eye | Red | |
| Atomoxetine | For attention deficit hyperactivity disorder (ADHD) in school-age children, adolescents and adults | Amber | |
| Avacopan | ANCA-positive vasculitis | Red | |
| Avanafil | Penile rehabilitation post radical prostatectomy or radiotherapy | Black | |
| Avanafil | Erectile dysfunction in adult males | Green | |
| Avastin | For neovascular glaucoma and neovascularization of the retina | Red | |
| Avelumab | Treatment of cancer (commissioned by NHS England) | Red | |
| Avoralstat | Hereditary angioedema | Red | |
| Axicabtagene ciloleucel | Treatment of cancer (commissioned by NHS England) | Red | |
| Axitinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Azacitidine | Treatment of cancer (commissioned by NHS England) | Red | |
| Azathioprine | Rheumatology - COVID-19 | Amber Azathioprine - COVID-19 | |
| Azathioprine | Licensed indications - rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis and polymyositis, auto-immune hepatitis Off-label indications - systemic vasculitis, inflammatory bowel diseases (Crohn’s disease, ulcerative colitis, microscopic colitis) | Amber | |
| Azathioprine | Dermatological conditions. Off-label: bullous pemphigoid, eczema, vasculitis & Behcets syndrome | Amber | |
| Azathioprine | Transplant immunosuppression | Amber Search for azathioprine/a> | |
| Azathioprine | Paediatric Inflammatory Bowel Disease (IBD) / Rheumatology | Amber | |
| Azithromycin | Long term treatment bronchiectasis & COPD | Green Specialist Initiation | |
| Aztreonam lysine | Cystic fibrosis (CF) Patients | Red | 20th September 2019 (a) |
| Bardoxolone methyl | Pulmonary arterial hypertension | Red | |
| Baricitinib | Moderate to severe active rheumatoid arthritis in adults who have responded inadequately, or intolerant to one or more DMARDs | Red | |
| Baricitinib | Paediatric indications (where adult NICE TA available) | Red | |
| Basiliximab | Renal transplant | Red | |
| Bath and Shower preparations | For all indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| BCG vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Becaplermin | Treatment of diabetic ulcers | Red | |
| Beclabuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Bedaquiline | TB | Red | |
| Begelomab | Graft versus host disease | Red | |
| Belatacept | Renal transplant | Red | |
| Belimumab | Systemic lupus erythematosus (SLE) | Red | |
| Bendamustine | Treatment of cancer (commissioned by NHS England) | Red | |
| Benralizumab | Asthma | Red | |
| Benzbromarone | Unlicensed medicine - Gout | Red | |
| Beperminogene perplasmid | Peripheral vascular disease | Red | |
| Beractant | Respiratory distress syndrome | Red | |
| Betaine | Homocystinuria | Red | |
| Bevacizumab | All indications | Red | |
| Bexarotene | Treatment of cancers | Red | |
| Bicalutamide | Locally advanced prostate cancer at high risk of disease progression. Locally advanced non-metastatic prostate cancer when surgical castration or other medical intervention inappropriate. Ongoing monotherapy for prostate cancer in patients wishing to preserve sexual function. Maximum androgen blockade – use continuously in conjunction with LHRH analogue for three months | Amber | |
| Bictecravir | HIV infection (commissioned by NHS England) | Red | |
| Biktarvy | Anti-retrovial - HIV | Red | 22nd January 2020 |
| Bimagrumab | Inclusion body myositis | Red | |
| Bimatoprost/timolol eye drops (Ganfort®) | Glaucoma | Green Specialist Initiation | |
| Biopatch® | Prevention of catheter site infection | Red | |
| Biotin | Vitamin induced hair loss. Multiple sclerosis (MS) | Red | |
| Bivalirudin | Use in perctaneous coronary intervention procedures | Red | |
| Blinatumomab | Recommended as an option for treating Philadelphia-chromosome-negative relapsed or refractory precursor B-cell acute lymphoblastic leukaemia in adults. | Red | |
| Blisibimod | Systemic lupus erythematosus (SLE) | Red | |
| Boceprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Bone morphogenic protein (dibotermin, eptotermin) | Complex spinal surgery (commissioned by NHS England) | Red | |
| Bortezomib | All indications | Red | |
| Bosentan | All indications | Red | |
| Bosutinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Botulinum toxin | All indications | Red | |
| Brentuximab | Treatment of cancer (commissioned by NHS England) | Red | |
| Brigatinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Brimapitide | Acute sensorineural hearing loss | Red | |
| Brimonidine gel | Treatment of facial erythema of rosacea in adults | Black | |
| Brincidofovir | Cytomegalovirus | Red | |
| Brivaracetam | As an adjunctive third line treatment option for the management of partial-onset seizures with or without secondary generalisation in adults. Brivaracetam may be considered if there is: • failure of one or more first line drugs (carbamazepine, lamotrigine or levetiracetam) AND • failure of one or more 2nd line drugs (topiramate, pregabalin, lacosamide, zonisamide or perampanel) | Green Specialist Initiation | |
| Brivaracetam | Partial onset seizures - for paediatric use | Green Specialist Initiation | 20th September 2019 (n) |
| Brodalumab | Paediatric indications (where adult NICE TA available) | Red | |
| Brodalumab | For moderate to severe plaque psoriasis in adults according to NICE TA511 | Red | |
| Budesonide orodisperisable tablets | For treatment of eosinophilic esophagitis (EoE) in adults | Red | |
| Bulkamid | Periurethral injection for the management of female stress incontinence | Red | |
| Burosumab | X-linked hypophosphataemia | Red | |
| Buserelin | Gonadorelin analogue - IVF | Red | |
| Busulfan | Treatment of cancer | Red | |
| C1 esterase inhibitors | Hereditary angioedema | Red | |
| Cabazitaxel | Treatment of cancer (commissioned by NHS England) | Red | |
| Cabotegravir | HIV infection (commissioned by NHS England) | Red | |
| Cabozantinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Canakinumab | Cryopyrin associated periodic syndrome and juvenile arthritis - paediatric | Red | |
| Cabergoline | Parkinson's disease | Green Specialist Initiation | |
| Calcifidiol | Inborn errors in primary bile acid synthesis | Red | |
| Calcipotriol / betamethasone scalp gel | Psoriasis | Green | |
| Canagliflozin | Type 2 diabetes (T2DM) | Green | |
| Cannabis-based products (not Sativex®) | See NHS England's Guidance Cannabis-based products | Black | |
| Cannabidiol (Epidyolex®) with clobazam | Dravet/Lennox gestaut syndrome | Red | |
| Capecitabine | All indications | Red | |
| Caphosol® oral rinse | For the prevention and treatment of mucositis caused by high dose chemotherapy | Red | |
| Capsaicin patches 8% | Neuropathic pain | Red | |
| Carfilzomib | Treatment of cancer (commissioned by NHS England) | Red | |
| Carglumic acid | Urea cycle disorders | Red | |
| Carnitine | Carnitine deficiency | Red | |
| Carnoys solution | Treatment of histological odentogenic keratocysts or recurrences | Red | 22nd January 2020 (n) |
| Caspofungin | Fungal infections | Red | |
| Catridecacog | Congenital factor XIIIa-subunit deficiency | Red | |
| Cenegermin | Neurotrophic keratitis | Red | |
| Ceralifimod | Multiple sclerosis (MS) | Red | |
| Ceritinib | All indications | Red | |
| Cerliponase alfa | Neuronal ceroid lipofuscinosis | Red | |
| Certolizumab pegol | All indications | Red | |
| Cetrorelix | IVF | Red | |
| Cetuximab | Treatment of cancer (commissioned by NHS England) | Red | |
| Chenodeoxycholic acid | Cerebrotendinous xanthomatosis and primary biliary cirrhosis | Red | |
| Chloral Hydrate | Insomnia (Short term use) | Red | |
| Chloral Hydrate (oral) | For paediatric neurology and palliative care | Green Specialist Initiation | |
| Chlorambucil | Treatment of cancers | Red | |
| Chlordiazepoxide | Acute alcohol withdrawal | Red | |
| Cholic acid | Inborn errors in primary bile acid synthesis | Red | |
| Chondroitin | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Chondriotin sulphate | Bladder instillation for Patients with damaged or glycosaminoglycan deficient bladder epithelium | Red | |
| Chorionic gonadotrophin | Gonadorelin analogue - IVF | Red | |
| Ciclosporin | Rheumatology COVID-19 | Amber Ciclosporin - COVID-19 | |
| Ciclosporin | Inflammatory bowel disease | Amber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Ciclosporin | Licensed indications: rheumatoid arthritis, psoriasis. Off-label indication: psoriatric arthritis | Amber | |
| Ciclosporin | Dermatological conditions. Licensed: atopic dermatitis. Off-label: bullous pemphigoid, pyoderma gangrenosum, hidradenitis suppurativa, pemphigus & lupus | Amber | |
| Ciclosporin | Bone marrow transplant | Amber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Ciclosporin | Paediatric Rheumatology | Amber | |
| Ciclosporin | Post-transplant | Amber | |
| Ciclosporin eye drops 1mg/ml (Ikervis®) | Persistent dry eye (NICE TA369) | Green Specialist Initiation (Indications other than NICE TA369 are Red) | |
| Cidofovir | Cytomegalovirus | Red | |
| Cinacalcet | Hypercalcaemia of primary hyperparathyroidism or parathyroid carcinoma | Amber | |
| Cinacalcet | Secondary hyper-parathyroidism in patients with end-stage renal disease on maintenance dialysis therapy | Amber | |
| Ciprofloxacin inhalation | Cystic fibrosis (CF) | Red | |
| Ciprofloxacin liposomal (inhaled) | Cystic fibrosis (CF) | Red | |
| Cladribine | Multiple sclerosis (MS) and pulmonary Langerhans histiocytosis | Red | |
| Clazakizumab | Antibody mediated rejection | Red | |
| Clinical trials material | All trials | Red | |
| Clofarabine | Treatment of cancer (commissioned by NHS England) | Red | |
| Clomifene | IVF treatment | Red | |
| Clopidogrel | Heart disease and stroke | Green | |
| Clozapine | Atypical Antipsychotic - Schizophrenia | Red | |
| CoaguCheK | For paediatric haematology - for Leeds Patients only | Green Specialist Initiation | 27th November 2019 (a) |
| Cobicistat | HIV infection (commissioned by NHS England) | Red | |
| Cobitolimod | Paediatric indications (where adult NICE TA available) | Red | |
| Co-careldopa intestinal gel | Severe Parkinson's disease | Red | |
| Co-Enzyme Q10 | Enzyme deficiency in children | Red | |
| Colief® drops | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Colesevelam | Hyperlipidaemia | Green | |
| Colestilan | Renal dialysis - adults | Red | |
| Colistimethate sodium - (Colomycin®) | Cystic fibrosis (CF) management | Amber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Colistimethate sodium - (Promixin®) | Cystic fibrosis (CF) management | Amber | |
| Colistimethate sodium - (Colomycin®) | Pseudomonas infection in the lungs | Amber | |
| Conestat alfa | Hereditary angioedema | Red | |
| Co-proxamol | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Cough and cold remedies | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Crizanlizumab | Sickle cell disease | Red | |
| Crizotinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Cyclic pyranopterin monophosphate | Molybdenum cofactor deficiency | Red | |
| Cyclophosphamide | All Indications | Red | |
| Cyproterone | Prostate cancer | Red for new patients Amber for existing patients only Amber | |
| Cyproterone (off-label indications) | Off-label indications | Red | |
| Cyproterone | Anti-androgen for gender dysphoria | Amber LHTH | 20th September 2019 (n) |
| Cysteamine (mercaptamine) | Nephropathic cystinosis | Red | |
| Cytotoxic injectable drugs | All indications | Red | |
| Dabigatran | See DOACs | See DOACs | |
| Dabrafenib | Treatment of cancer | Red | |
| Daclatasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Daclizumab | Multiple sclerosis (MS) | Red | |
| Dalteparin | See low molecular weight heparins (LMWH) | See low molecular weight heparins (LMWH) | |
| Dapagliflozin | Type 2 diabetes (T2DM) | Green | |
| Dapoxetine | Premature ejaculation | Black | |
| Dapsone | Licensed indication- Dermatitis herpetiformis, and off-label indications - dermatoses (leucocytoclastic vasculitis, Sweet's syndrome, pyoderma gangrenosum) | Amber | |
| Daratumunab | Treatment of cancer (commissioned by NHS England) | Red | 31st July 2019 (n) |
| Darbepoetin alfa | All indications | Red | |
| Darunavir | HIV infection (commissioned by NHS England) | Red | |
| Darunavir/cobicistat | HIV infection (commissioned by NHS England) | Red | |
| Dasabuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Dasatinib | Treatment of cancer (commissioned by NHS England) | Red | |
| Daunorubicin | Treatment of cancer (commissioned by NHS England) | Red | |
| Decitabine | Treatment of cancer (commissioned by NHS England) | Red | |
| Deferasirox | Iron chelation in thalassaemia and sickle cell | Red | |
| Deferiprone | Iron chelation in thalassaemia and sickle cell | Red | |
| Defibrotide | Hepatic veno-occlusive disease | Red | |
| Degarelix | Prostate cancer | Red | |
| Delamanid | Extensively drug-resistant TB and multi drug-resistant TB | Red | |
| Denosumab | Prevention of osteoporosis | Amber SWYAPC | |
| Denosumab | Prevention of skeletal events from breast cancer | Red | |
| Dental products on FP10 | Black with the exception of those patients on specialist advice following treatment for head and neck cancers (GSI) See NHSE Guidance on the conditions for which over the counter items should not routinely be prescribed in primary care. | ||
| Dequalinium chloride | Bacterial vaginosis | Red | 31st July 2019 (n) |
| Desferrioxamine | Iron chelation in thalassaemia and sickle cell | Red | |
| Dexamethasone intravitreal implant | Macular oedema | Red | |
| Dexamfetamine | For attention deficit hyperactivity disorder (ADHD) in school-age children, adolescents and adults | Amber | |
| Dexmedetomide | Maintenance of sedation during intensive care | Red | |
| Dexrazoxane | Anthracycline extravasation and cardiotoxicity (NHS England) | Red | |
| Dibotermin alfa | Complex spinal surgery (commissioned by NHS England) | Red | |
| Dichlorphenamide | Primary hypo and hyperkalaemic periodic paralysis | Red | |
| Didanosine | HIV infection (commissioned by NHS England) | Red | |
| Dihydrotestosterone (Androstanolone®) | Unlicensed - recommendation from Leeds paediatric surgeons | Red | |
| Dimethyl fumarate | Multiple sclerosis (MS)/psoriasis (commissioned by NHS England) | Red | |
| Dinoprostone vaginal delivery system | Cervical ripening/induction of labour | Red | |
| Dinutuximab | Treatment of cancer (commissioned by NHS England) | Red | |
| Diphoterine | Solution used as a spray/wash for caustic burns to skin/eye. | Red | |
| Diroximel fumarate | Multiple sclerosis (MS) | Red | |
| Disodium pamidronate (IV) | Bisphosphonate - all licensed indications | Red | |
| Disulfiram | Management of patients with drinking problems | Amber | |
| Diveen ® | Stress Incontinence | Black not yet classified | 18th March 2020 (n) |
| DOACs | Red for prevention of venous thromboembolic events (VTE) in adults who have undergone elective hip or knee replacement surgery. Red for acute coronary syndrome (ACS). Full courses supplied through Acute Trust. GSI for treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults, subject to local policy. Green for prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation, with one or more risk factors, subject to local policy. Check licensed indications and doses of individual drugs | Red for prevention of venous thromboembolic events (VTE) in adults who have undergone elective hip or knee replacement surgery. Red for acute coronary syndrome (ACS). Full courses supplied through Acute Trust. GSI for treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults, subject to local policy. Green for prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation, with one or more risk factors, subject to local policy. Check licensed indications and doses of individual drugs | |
| Docetaxel | Advanced/metastatic breast cancer, prostate cancer | Red | |
| Dolutegravir | HIV infection (commissioned by NHS England) | Red | |
| Donepezil | Mild to moderate dementia in Alzheimer's disease | Green Specialist Initiation | |
| Domagrozumab | Duchenne muscular dystrophy | Red | |
| Dornase alfa | Cystic fibrosis (CF) management | Amber | |
| Dornase alfa | Primary ciliary dyskinesia | Red | |
| Doravirine | HIV infection (commissioned by NHS England) | Red | |
| Dosulepin | All indications | Black for new patients for all indications NHSE items that should not be routinely prescribed in Primary Care | |
| Doxazosin MR | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Drisapersen | Duchenne muscular dystrophy | Red | |
| Dronedarone | Cardiac arrhythmia | Green Specialist Initiation | |
| Dronedarone | Cardiac arrhythmia | Black for new patients NHSE items that should not be routinely prescribed in Primary Care | |
| Droperidol injection | Post operative nausea and vomiting | Red | |
| Dulaglutide | Type 2 diabetes | Green | |
| Duloxetine | Pain - nerve | Green | |
| Dupilumab | Asthma | Red | |
| Dupilumab | For atopic dermatitis in adults according to NICE TA534 | Red | |
| Durvalumab | Cancer | Red | 27th November 2019 (n) |
| Ecallantide | Hereditary angioedema | Red | |
| Eculizumab | All indications | Red | |
| Edasalonexent | Duchenne muscular dystrophy | Red | |
| Edoxaban | See DOACs | See DOACs | |
| Edratide | Systemic lupus erythematosus (SLE) | Red | |
| Efavirenz | HIV infection (commissioned by NHS England) | Red | |
| Eflornithine cream | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Efraloctocog alfa/efmoroctocog alfa/factor VIII FC fusion protein | Haemophilia A | Red | |
| Eftrenonacog alfa | Haemophilia B | Red | |
| Elbasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Eliglustat | Gaucher's disease | Red | |
| Elosulfase alfa | Mucopolysacchardosis IV type A | Red | |
| Eltrombopag | Immune (idiopathic) thrombocytopenic purpura | Red | |
| Elvitegravir | HIV infection (commissioned by NHS England) | Red | |
| Elvucitabine | HIV infection (commissioned by NHS England) | Red | |
| Emapalumab | Haemophagocytic lymphohistiocytosis | Red | |
| Emicizumab | As per BCSH guidelines for specialised indications | Red | |
| Empagliflozin | Type 2 Diabetes | Green Specialist Initiation | 27th November 2019 (n) |
| Emricasan | Non-alcoholic steatohepatitis (NASH) fibrosis | Red | |
| Emtricitabine | HIV infection (commissioned by NHS England) | Red | |
| Emtricitine/rilpivirine/tenofovir alafenamide | HIV infection (commissioned by NHS England) | Red | |
| Emtricitine/rilpivirine/tenofovir alafenamide | HIV infection (commissioned by NHS England) | Red | |
| Emtricitine/tenofovir/darunavir/cobicistat | HIV infection (commissioned by NHS England) | Red | |
| Emtricitine/tenofovir/elvitegravir/cobicistat | HIV infection (commissioned by NHS England) | Red | |
| Emtricitine/tenofovir | HIV infection (commissioned by NHS England) | Red | |
| Enfuvirtide | HIV infection (commissioned by NHS England) | Red | |
| Enstilar® (calcipotriol and betamethasone) | Psoriasis | Green if failed on individual components | |
| Enoxaparin | See low molecular weight heparins (LMWH) | See low molecular weight heparins (LMWH) | |
| Entecavir | Chronic Hepatitis B infection | Red | |
| Enzalutamide | Treatment of cancers | Red | |
| Epoetin (all variants) | All indications | Red | 22nd January 2020 from Amber |
| Epoprostenol | Off-label indications and pulmonary arterial hypertension | Red | |
| Epratuzumab | Systemic lupus erythematosus (SLE) | Red | |
| Eprodisate | Amyloidosis | Red | |
| Eptotermin alfa | Complex spinal surgery (commissioned by NHS England) | Red | |
| Erenumab | Migraine | Black | 16.10.19 |
| Eribulin | Treatment of cancers | Red | |
| Erlotinib | Treatment of cancers | Red | |
| Ertugliflozin | Type 2 diabetes | Green | 31st July 2019 (n) |
| Eslicarbazepine | Epilepsy | Green Specialist Initiation | |
| Estramustine | Treatment of cancers | Red | |
| Etanercept | All indications | Red | |
| Etelcalcetide | Hyperparathyroidism -dialysis patients only | Red | |
| Eteplirsen | Duchenne muscular dystrophy | Red | |
| Ethambutol | Treatment of TB | Red | |
| Etoposide | Treatment of cancers | Red | |
| Etravirine | HIV infection (commissioned by NHS England) | Red | |
| Etrolizumab | Paediatric indications (where adult NICE TA available) | Red | |
| Everolimus (Afinitor®) | Treatment of cancers | Red | |
| Everolimus (Certican®) | Preventing transplant rejection | Red | |
| Everolimus (Votubia®) | Tubular sclerosis | Red | |
| Evicel® | Tissue adhesive - for use in patients undergoing pelvic surgery or laparoscopic partial nephrectomies | Red | |
| Evolocumab | Homozygous familial hypercholesterolaemia | Red | |
| Exemestane | Breast Cancer | Green Specialist Initiation | |
| Exenatide | Type 2 diabetes (T2DM) | Green | |
| Exenatide weekly | Type 2 diabetes (T2DM) | Green | |
| Ex-vivo expanded autologous human corneal epithelial cells containing stem cells | Limbal stem cell deficiency | Red | |
| Factor IX | As per BCSH guidelines for specialised indications | Red | |
| Factor VII | As per BCSH guidelines for specialised indications | Red | |
| Factor VIIa (Recombinant) (NovoSeven®) | Bleeding episodes in surgery in specific patients | Red | |
| Factor VIIa | As per BCSH guidelines for specialised indications | Red | |
| Factor VIII | As per BCSH guidelines for specialised indications | Red | |
| Factor VIII inhibitor bypassing factor | As per BCSH guidelines for specialised indications | Red | |
| Factor X | Hereditary factor X deficiency | Red | |
| Factor XIII | As per BCSH guidelines for specialised indications | Red | |
| Fampridine | Multiple sclerosis (MS) | Red | |
| Febuxostat | In line with NICE for patients intolerant of allorpurinol | Green | |
| Fentanyl nasal spray | Pain relief - use should be restricted to palliative care consultants | Green Specialist Initiation | |
| Fentanyl IR | For non palliative care indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Ferric carboxymaltose | Iron-deficiency anaemia | Red | |
| Ferric carboxymaltose | Heart failure patients with or without decreased haemoglobin levels | Red | |
| Fesoterodine | Overactive bladder syndrome | Green | |
| Fiasp® (insulin aspart) | Treatment of diabetes in adult patients with Type 1 diabetes who are likely to benefit directly from a more rapid onset of action, including: 1.Pregnancy 2.Use of insulin pump 3.Young adults unable to manage with Novorapid because of poor post-prandial glucose control, despite adequate therapeutic trial | Green Specialist Initiation | |
| Fibrinogen | As per BCSH guidelines for specialised indications | Red | |
| Fibroblast growth factor 1 gene therapy | Somatostatin analogue | Red | |
| Fidaxomicin | Treatment of Clostridium difficile infection only when it prevents admission to hospital or severe illness | Green Specialist Initiation | |
| Filgotinib | Paediatric indications (where adult NICE TA available) | Red | |
| Filgrastim | Neutropenia and Barth syndrome | Red | |
| Filibuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Fingolimod | Management of multiple sclerosis | Red | |
| Fitusiran | Haemophilia A And B | Red | |
| Flash glucose monitoring systems | Type 1 diabetes mellitus for patients who fulfil the criteria | Green Specialist Initiation | |
| Flebogamma® | All indications | Red | |
| Flebogammadif® | All indications | Red | |
| Flecainide | Tachyarrhythmias | Green Specialist Initiation | |
| Fludarabine | Treatment of cancers | Red | |
| Fluocinolone acetonide intravitreal implant | Treatment of chronic diabetic macular oedema | Red | |
| Fluorouracil/salicylic acid (Actikerall®) | Management of actinic keratosis | Green | |
| Flupentixol depot injection | Depot antipsychotic for schizophrenia | Green Specialist Initiation | |
| Fluphenazine depot injection | Depot antipsychotic for schizophrenia (to be discontinued at the end of 2018 - no new patients should be started on this if treatment is expected to continue beyond 2018) | Green Specialist Initiation | |
| Flutamide | Advanced prostate cancer patients for: Long term palliative therapy when LHRH analogues or orchidectomy is contraindicated, not tolerated or oral therapy preferred. Hot flushes with LHRH analogue therapy or after orchidectomy | Amber | |
| Fluticasone furoate nasal spray | rhinitis | Green | |
| Follitropin alfa/beta | IVF - Gonadotrophin | Red | |
| Fondaparinux | Parenteral anticoagulant | Red | |
| Forigerimod acetate | Systemic lupus erythematosus (SLE) | Red | |
| Fosamprenavir | HIV infection (commissioned by NHS England) | Red | |
| Fosaprepitant injection | Chemotherapy induced nausea and vomiting | Red | |
| Foscarnet | Cytomegalovirus | Red | |
| Fosfomycin IV | 2nd line antibiotic for patients with carbapenemase resistant infections or with confirmed anaphylactoid reaction to penicillins presenting with suspected meningitis | Red | |
| Fosfomycin | Urinary tract infections (UTIs) (sensitivities reported by Microbiology) | Green Specialist Initiation | |
| Fostemsavir | HIV infection (commissioned by NHS England) | Red | |
| Fremanezumab | Migraine | Black | 16.10.19 |
| Fulvestrant | Breast cancer | Red | |
| Galantamine | Mild to moderate dementia in Alzheimer's disease | Green Specialist Initiation | |
| Galcanezumab | Migraine | Black | 16.10.19 |
| Galsulfase | Mucopolysaccharidosis | Red | |
| Galunisertib | Treatment of cancer | Red | |
| GammaCore ® | Red for Cluster Headaches Black for all other indications | Red | 18th March 2020 (n) |
| Gammagard® | All indications | Red | |
| Gammanorm® | All indications | Red | |
| Gammaplex® | All indications | Red | |
| Gamunex® | All indications | Red | |
| Ganetespib | Treatment of cancers | Red | |
| Ganciclovir | Cytomegalovirus (CMV) | Red | |
| Gefitinib | Treatment of cancers (commissioned by NHS England) | Red | |
| Gemcitabine | Treatment of cancer (commissioned by NHS England) | Red | 31st July 2019 (n) |
| Gemtuzumab ozogamicin | Treatment of cancers (commissioned by NHS England) | Red | |
| Gender dysphoria or reassignment drugs | Guidance available from Leeds Health Pathways (search 'gender') | See information from Leeds | |
| Gevokizumab | Uveitis | Red | |
| Givosiran | Hepatic porphyria | Red | |
| Glatiramer | Multiple sclerosis (MS) | Red | |
| Glecaprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Glucosamine | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Glucarpidase | Methotrexate-induced renal dysfunction | Red | |
| Glycerol phenylbutyrate | Urea cycle disorders | Red | |
| Glycopegylated factor IX | Haemophilia A | Red | |
| Glycopyrronium (oral) | Hypersalivation (adults and children) | Amber Glycopyrronium SCG LTHT* | |
| Glycopyrronium (topical) | Hyperhidrosis | Red | |
| GnRH analogues (Leuprorelin or Triptorelin) | Endometriosis or uterine fibroids | Amber | |
| GnRH analogues (Goserelin, Leuproelin, Triptorelin) | Management of prostate cancer | Amber | |
| Golimumab | All indications | Red | |
| Gonadorelin | IVF - hypothalmic hormone | Red | |
| Gonasi | As a sourced alternative as Pregnyl brand hCG has been discontinued for hypogonadotrophic hypogonadism | Red | |
| Goserelin | Management of prostate cancer | Amber - see GnRH analogues | |
| Goserelin | IVF - gonadorelin analogue | Red | |
| Goserelin | Endometriosis | Amber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Goserelin | For breast cancer | Green Specialist Initiation | |
| Granulocyte-macrophage colony-stimulating factor | Antibody-positive pulmonary alveolar proteinosis | Red | |
| Grazoprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Grazax® | Seasonal allergic hayfever | Red | |
| Guanfacine | Attention deficit hyperactivity disorder (ADHD) in school age children, adolescents and adults | Amber | |
| Guselkumab | For moderate to severe plaque psoriasis in adults according to NICE TA521 | Red | |
| Haloperidol depot injection | Depot antipsychotic for schizophrenia | Green Specialist Initiation | |
| Haemorrhoid preparations available over-the-counter | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Herbal | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Hepatitis B vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| HIV-fusion inhibitors | HIV infection (commissioned by NHS England) | Red | |
| HIV-integrase inhibitors | HIV infection (commissioned by NHS England) | Red | |
| HIV vaccine | HIV infection prophylaxis (commissioned by NHS England) | Red | |
| Hizentra® | All indications | Red | |
| Homeopathic medicines | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Human alpha-1 proteinase inhibitor | Emphysema | Red | |
| Human (haem) arginate | Hepatic porphyria | Red | |
| Human menopausal gonadotrophins | IVF - Gonadotrophin | Red | |
| Human heterologous liver cells | Urea cycle disorders | Red | |
| Human parathyroid hormone-related protein analogue | Male and juvenile osteoporosis hypoparathyroidism | Red | |
| Hyaluronic acid derivatives (injectables) | Osteoarthritis and other joint conditions | Black | |
| Hydrocortisone MR | Replacement in adrenocortical insufficiency | Black | |
| Hydroxycarbamide | Treatment of solid tumours | Red | |
| Hydroxycarbamide | Haematological conditions | Amber | |
| Hydroxycarbamide | Psoriasis (off-label) | Amber | |
| Hydroxychloroquine | Interstitial Pneumonitis in children | Green Specialist Initiation see LTHT guidance for information | |
| Hydroxychloroquine | Paediatric Rheumatology | Green Specialist Initiation See LTHT guidance for information | |
| Hydroxychloroquine | Rheumatology - COVID-19 | Amber Hydroxychloroquine - COVID-19 | |
| Hydroxychloroquine | Rheumatoid arthritis, systemic and discoid lupus erythematosus (and related connective tissue diseases – off-label) | Amber | |
| Hydroxyprogesterone caproate | Prevention of recurrent miscarriages | Red | |
| Hyqvia® | All indications | Red | |
| Ibalizumab | HIV infection (commissioned by NHS England) | Red | |
| Ibandronic acid tablets 50mg | Post-menopausal women with breast cancer | Green Specialist Initiation | |
| Ibandronic acid injection | Bisphosphonate - all licensed indications | Red | |
| Ibrutinib | Treatment of cancers | Red | |
| Icatibant | Hereditary angioedema | Red | |
| Idarubicin | Treatment of cancers | Red | |
| Idebenone | Duchenne muscular dystrophy | Red | |
| Idelalisib | Treatment of cancers | Red | |
| Idursulfase | Mucopolysaccharidosis | Red | |
| Iloprost | Pulmonary arterial hypertension | Red | |
| Imatinib mesilate | All indications | Red | |
| Imetelstat | Treatment of cancer | Red | |
| Imiglucerase | Enzyme replacement - Gaucher's disease | Red | |
| Imiquimod | Anogenital warts | Green Specialist Initiation | |
| Immunoglobulin - Intravenous (IVIg) | All indications | Red | |
| Indinavir | HIV infection (commissioned by NHS England) | Red | |
| Indocyanine dye | Ophthalmology | Red | |
| Ineblizumb | Multiple sclerosis (MS) | Red | |
| Infliximab | All indications | Red | |
| Influenza intra-nasal vaccine | Protection against flu | Green | |
| Ingenol mebotate | Management of actinic keratosis | Green | |
| Inotersen | Amyloidosis | Red | |
| Inotuzumab ozogamicin | Treatment of cancers (commissioned by NHS England) | Red | |
| Insulin degludec | Diabetes mellitus (DM) | Green Specialist Initiation | |
| Insulin glargine (Abasaglar®) | Diabetes mellitus (DM) | Green | |
| Insulin glargine (Toujeo®) | Diabetes mellitus (DM) | Green | |
| Insulin - Humulin R® - U500 | 500 unit/mL insulin for use in severely insulin resistant patients | Red | |
| Interferon alfa | All licensed indications | Red | |
| Interferon beta | Multiple sclerosis | Red | |
| Intratect® | All indications | Red | |
| Intravenous (IV) normal human immunoglobulins | All indications | Red | |
| Ipilimumab | Treatment of cancers | Red | |
| Irinotecan | Metastatic colorectal cancer used with 5-FU and folinic acid | Red | |
| Iron sucrose | Iron deficiency anaemia requiring intravenous therapy | Red | |
| Isavuconazole | Fungal infection (licensed indications) | Red | |
| Isoniazid | Treatment of TB | Red | |
| Isotretinoin | Oral retinoid - acne | Red | |
| Ivabradine | Angina in sinus rhythm | Green Specialist Initiation | |
| Ivacaftor | Red for newly diagnosed cystic fibrosis (CF) patients | Red | |
| Ivermectin cream | Rosacea | Green | |
| IVF Treatment | All drugs | Red | |
| Ixazomib | All indications | Red | |
| Ixekizumab | Psoriatic arthritis in adult patients | Red | 31st July 2019 (n) |
| Japanese encephalitis | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Ketamine | All indications | Red | |
| Ketogenic dietary products | For paediatric patients with epilepsy on a ketogenic diet and under the care of the regional service. See link to LTHT for additional information on ketogenic prescribable products | Green Specialist Initiation | |
| Kiovig® | All indications | Red | |
| Lacosamide | Resistant partial seizures | Green Specialist Initiation | |
| Lamivudine | Hepatitis B (commissioned by NHS England) | Red | |
| Lamivudine | HIV infection (commissioned by NHS England) | Red | |
| Lamivudine/abacavir/dolutegravir | HIV infection (commissioned by NHS England) | Red | |
| Lamivudine/zidovudine | HIV infection (commissioned by NHS England) | Red | |
| Lamivudine/zidovudine/abacavir | HIV infection (commissioned by NHS England) | Red | |
| Lanadelumab | Hereditary angioedema | Red | |
| Lanreotide | Neuroendocrine tumours, acromegaly | Amber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Lanreotide | Red for NHS England indications | Red | |
| Lanthanum | Control of hyperphosphataemia in patients with chronic renal failure | Amber | |
| Lapatinib | Cancer | Red | |
| Laquinimod | Multiple sclerosis (MS) | Red | |
| Laronidase | Mucopolysaccharidosis | Red | |
| Lebrikizumab | Asthma | Red | |
| Ledipasvir/sofosbuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Leflunomide | Rheumatology - COVID-19 | Amber Leflunomide - COVID-19 | |
| Leflunomide | Rheumatoid arthritis and psoriatic arthritis | *Please note: awaiting regional update of guidelines* Amber | |
| Lenalidomide | All indications | Red | |
| Lenograstim | Recombinant human granulocyte - colony stimulating factor - neutropenia and Barth syndrome | Red | |
| Lenvatnib | Cancer | Red | |
| Leronlimab | HIV infection (commissioned by NHS England) | Red | |
| Letermovir | Cytomegalovirus | Red | |
| Letrozole | Advanced breast cancer - long term therapy | Green Specialist Initiation | |
| Leuprorelin | Endometriosis or uterine fibroids | Amber - see GnRH analogues | |
| Leuprorelin | Management of prostate cancer | Amber - see GnRH analogues | |
| Levamisole | For paediatric nephrotic syndrome | Amber LHTH | |
| Levamisole | For hookworm and roundworm | Red | 31.7.19 (n) |
| Levetiracetam injection | For palliative care | Green Specialist Initiation | |
| Levofloxacin (inhaled) | Cystic fibrosis (CF) | Red | |
| Levoketoconzaole | Cushing's disease | Red | |
| Levonorgestrel | Contraception | Green | 27th November 2019 (n) |
| Lidocaine plasters | Post-herpetic neuralgia | Green Specialist Initiation | |
| Lidocaine plasters | For all unlicensed use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Lift® | Treatment of hypoglycaemia | Black - not yet classified | 27th November 2019 (n) |
| Linezolid | Antibiotic - Microbiologist initiation only | Red | |
| Liothyronine and liothyronine with levothyroxine | Hypothyroidism | Amber WYH Commissioning Statement | |
| Liothyronine and liothyronine with levothyroxine | Thyroid cancer | Red | |
| Liothyronine and liothyronine with levothyroxine | For all other indications | Black | |
| Lipegfilgrastim | Neutropenia | Red | |
| Liposomal cytarabine-daunorubicin | Treatment of cancer (commissioned by NHS England) | Red | |
| Liraglutide | Management of obesity | Black | |
| Liraglutide | Type 2 diabetes (T2DM) | Green | |
| Lisdexamfetamine | For attention deficit hyperactivity disorder (ADHD) in school-age children, adolescents and adults | Amber | |
| Lithium | Rheumatology COVID-19 | Amber Lithium COVID-19 | |
| Lithium | Treatment and prophylaxis of mania, bipolar disorder and recurrent depression | Amber To refer patients back into the service who have been discharged - please see the link to the SWYPFT Service directory | |
| Lithium carbonate | Motor neurone disease (MND) | Red | |
| Lixisenatide | Type 2 diabetes (T2DM) | Green | |
| Lixivaptan | Hyponatraemia and other endocrine uses | Red | |
| Lomustine | Treatment of cancers | Red | |
| Lomitapide | Homozygous familial hypercholesterolemia | Red | |
| Lonafarnib | Treatment of cancers | Red | |
| Lopinavir/ritonavir | HIV infection (commissioned by NHS England) | Red | |
| Loteprednol | Peri-operative use | Red | |
| Loteprednol | Glaucoma | Green Specialist Initiation | |
| Low molecular weight heparin (LMWH) - this includes: dalteparin, enoxaparin and tinzaparin | Urgent bridging of patients on warfarin (for VTE or heart valve), with significantly sub-therapeutic INR, in accordance with provider dosing guidance (taking account of patient weight and renal function) | Green Specialist Initiation | |
| Low molecular weight heparin (LMWH) - this includes: dalteparin, enoxaparin and tinzaparin | Pre-procedural bridging therapy for patients usually on warfarin (as directed by surgeon/clinical haematologist). Pre-procedural bridging therapy for patients usually on warfarin (as directed by surgeon/clinical haematologist). Extended post-operative thromboprophylaxis. High risk patients with plaster cast (about 6 weeks whilst immobile) – off-label. Treatment of acute VTE & maintenance during pregnancy. Antenatal thromboprophylaxis in women at high risk of VTE in pregnancy. Postpartum thromboprophylaxis in high risk women (7 days or 6 weeks) | Red | |
| Low molecular weight heparin (LMWH) - this includes: dalteparin, enoxaparin and tinzaparin | Treatment of adult patients with venous thromboembolism (VTE) presenting clinically as deep vein thrombosis (DVT), pulmonary embolism (PE) or both. LMWHs may be used in: - •Patients unable to take warfarin and in whom a direct oral anticoagulant (DOAC) is not appropriate or contraindicated. •Patients in whom it has not been possible to stabilise on oral anticoagulant therapy and in whom a DOAC is not appropriate or contraindicated (for example: a patient with a replacement metal mitral heart valve and a sub-therapeutic INR and ‘bridging’ therapy is required). •IV drug users (where warfarin is generally considered inappropriate) and in whom a DOAC is not appropriate or contraindicated. . | Amber | |
| Low molecular weight heparin (LMWH) - this includes: dalteparin, enoxaparin and tinzaparin | Extended treatment & prophylaxis of VTE in adult patients with solid tumours | Amber | |
| Lubiprostone | Treatment of chronic idiopathic constipation | Green Specialist Initiation | |
| Lumacaftor/ivacaftor | Cystic fibrosis (CF) | Red | |
| Lurasidone | Schizophrenia (adults) | Green Specialist Initiation | |
| Luspatercept | Treatment of cancer | Red | |
| Lutetium (177lu) oxodotreotide | Treatment of cancer (commissioned by NHS England) | Red | |
| Lutein and antioxidants | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Macimorelin | Growth failure | Red | |
| Macitentan | Pulmonary arterial hypertension | Red | |
| Mannitol dry powder inhaler | Treatment of cystic fibrosis | Red | |
| Maralixibat | Alagille syndrome (commissioned by NHS England) | Red | |
| Maribavir | Cytomegalovirus (commissioned by NHS England) | Red | |
| Maraviroc | HIV infection (commissioned by NHS England) | Red | |
| Masitinib | Pancreatic cancer. Gastrointestinal stoma tumour (GIST) | Red | |
| Mavrilimumab | Paediatric indications (where adult NICE TA available) | Red | |
| Mecasermin | Growth failure | Red | |
| Melatonin MR | Treatment of sleep disorders in children and young people under 18 years | Amber. Leaflet for patients Crushing Circadin tablets leaflet | |
| Melatonin MR | Cerebral palsy - these patients will require longer term treatment – there are no drug monitoring/blood monitoring requirements | Green Specialist Initiation | |
| Melatonin 1mg/ml oral solution | Jet lag in adults | Black | 31st July 2019 (n) |
| Melphalan | Treatment of cancers | Red | |
| Memantine | Moderately severe to severe Alzheimers disease. | Green Specialist Initiation | |
| Meningitis ACWY vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Mepacrine | Malaria | Red | 22nd January 2020 |
| Mepolizumab | Asthma | Red | |
| Mercaptopurine | Rheumatology - COVID-19 | Amber Mercaptopurine - COVID-19 | |
| Mercaptopurine | Gastroenterology | Amber | |
| Mercaptopurine | For the treatment of Inflammatory Bowel Disease in Children | Amber | |
| Mercaptopurine | Treatment of cancers | Red | |
| Mesalazine MR (Mezavant®) | For the induction of clinical and endoscopic remission in patients with mild to moderate, active ulcerative colitis. For maintenance of remission | Green | |
| Mesenchymal stem cells | All indications | Red | |
| Methotrexate | Rheumatology - COVID-19 | Amber Methotrexate - COVID-19 | |
| Methotrexate (oral, IM & SC) | Cancer indications | Red | |
| Methotrexate (IM and SC) | Non-cancer indications | Red | |
| Methotrexate (oral) | Licensed indications – Rheumatoid arthritis, Psoriatic arthritis Off-label indication - Other inflammatory arthritides, connective tissue disease (not for cancer or dermatological conditions) | Amber | |
| Methotrexate (oral) | Licensed indication: severe uncontrolled psoriasis. Off-label conditions: e.g pemphigoid, pemphigus, sarcoidosis, scleroderma, dermatomyositis, eczema. See shared care guideline for further indications | Amber | |
| Methotrexate (oral) | Non cancer indications in paediatrics | Amber | |
| Methylnaltrexone subcutaneous injection | Severe opioid induced constipation | Black | |
| Methylphenidate | For ADHD in school-age children, adolescents and adults | Amber | |
| Metolazone | Heart failure | Green Specialist Initiation | |
| Metyrapone | Management of patients with Cushing’s Syndrome | Red for new patients Green Specialist Initiation for existing patients | |
| Metreleptin | Dyslipidaemia (commissioned by NHS England) | Red | |
| Mexiletine | Non-dystrophic myotonia (commissioned by NHS England) | Red | |
| Mexiletine | Treatment of life-threatening ventricular arrhythmias | Red | |
| Micafungin | Fungal infections | Red | |
| Miconazole buccal | Oropharyngeal candidiasis | Green Specialist Initiation | |
| Midazolam oromucosal solution | Convulsive seizures | Green Specialist Initiation | |
| Midodrine | In adults for the treatment of severe orthostatic hypotension due to autonomic dysfunction when corrective factors have been ruled out and other forms of treatment are inadequate. | Green Specialist Initiation | |
| Midostraurin | Treatment of cancers (commissioned by NHS England) | Red | |
| Migalastat | Fabry's disease | Red | |
| Miglustat | Gaucher's disease/Niemann-Pick disease | Red | |
| Minocycline for acne | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Mirabegron | Overactive bladder syndrome | Green | |
| Mitotane | Treatment of cancers | Red | |
| Modafinil | Treatment of adults with excessive sleepiness associated with chronic pathological conditions, including narcolepsy. Multiple sclerosis (MS) and Parkinson's disease are to be included as they are chronic pathological conditions | Amber | |
| Mogamulizumab | Sezary Syndrome | Red | 18th March 2020 (n) |
| Momelotinib | Treatment of cancers | Red | |
| Motavizumab | Prophylaxis of respiratory syncytial virus (RSV) | Red | |
| Mycophenolate | Off-label indications –systemic lupus erythematosus (SLE), particularly lupus nephritis, other connective tissue diseases and systemic vasculitis. Treatment of myasthenia gravis in patients intolerant or non-responding to azathioprine | *Please note: awaiting regional update of guidelines* Amber | |
| Mycophenolate | Cytotoxic immunosuppressant - prophylaxis of acute transplant rejection | Amber | |
| Mycophenolate | Indications not classified as amber | Red | |
| Mycophenolate | Paediatric rheumatology | Amber | |
| Mycophenolate | For the prevention of relapse in frequently relapsing nephrotic syndrome in paediatrics | Amber | |
| Mydrane | As drug to dilate pupil and also prevent pupil becoming small during Cataract surgery | Red | 22nd January 2020 |
| Mysimba® (naltrexone plus bupropion) | For the treatment of overweight and obesity | Black | |
| Nabilone | Antiemetic; Multiple sclerosis treatment | Red | |
| Nafarelin | IVF - gonadorelin analogue | Red | |
| Nalmefene (only for patients under the care of alcohol services including shared care) | Alcohol dependence | Red | |
| Naloxegol | For opioid-induced constipation according to NICE TA345 | Green Specialist Initiation | |
| Naltrexone | Maintain abstinence in alcohol-dependent patients | Amber | |
| Naltrexone | Hailey-Hailey disease | Red | 20th September 2019 (n) |
| Nasal sprays available over-the-counter for symptomatic relief of hay fever and congestion | See separate grey list (DROP-List) | Grey (DROP-List) | |
| Natalizumab | Multiple sclerosis (MS) | Red | |
| Needles for pre-filled and reusable Insulin pens | For needles costing more than £5 per 100 | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Nefopam | Pain | Black for new patients | |
| Nelarabine | Treatment of cancers | Red | |
| Nelfinavir | HIV infection (commissioned by NHS England) | Red | |
| Neomycin oral tablet | Surgical prophylaxis alongside oral metronidazole, plus standard intravenous surgical prophylaxis for colorectal surgery – with mechanical bowel preparation | Red | |
| Nephro-vite® | Vitamin supplementation in renal impairment | Green Specialist Initiation | |
| Neratinib | Breast Cancer | Red | 27th November 2019 (n) |
| Netupitant and palonosetron | Anti-emetic for use with cancer chemotherapy | Red | |
| Nevirapine | HIV infection (commissioned by NHS England) | Red | |
| Nilotinib | Treatment of cancers | Red | |
| Nintedanib | Treatment of cancers; idiopathic pulmonary fibrosis | Red | |
| Niraparib | Treatment of cancers | Red | |
| Nitazoxanide | Unlicensed in UK - for treatment of Cryptosporidiosis and Giardiasis | Red | |
| Nitazoxanide | Hepatitis C (commissioned by NHS England) | Red | |
| Nitisinone | Alkaptonuria; tyrosinaemia | Red | |
| Nitric oxide | Pulmonary arterial hypertension | Red | |
| Nivolumab | Treatment of cancers | Red | |
| NOACs | See DOACs | See DOACs | |
| Nonacog alpha | Haemophilia B | Red | |
| Nonacog beta pegol | Haemophilia B | Red | |
| Non-nucleoside reverse transcriptase inhibitors | HIV infection (commissioned by NHS England) | Red | |
| Normal immunoglobulin | All indications | Red | |
| Nucleoside reverse transcriptase inhibitors (nucleoside analogues) | HIV infection (commissioned by NHS England) | Red | |
| Nusinersen | Spinal muscular atrophy (commissioned by NHS England) | Red | |
| Obeticholic acid | Primary biliary cirrhosis | Red | |
| Obinutuzumab | Treatment of cancers | Red | |
| Ocrelizumab | Multiple sclerosis (MS) | Red | |
| Ocriplasmin | Retinal disorders | Red | |
| Octagam® | All indications | Red | |
| Octocog alfa | Haemophilia A | Red | |
| Octreolin | Acromegaly | Red | |
| Octreotide | For palliative care indications | Green Specialist Initiation | |
| Octreotide | Amber for licensed CCG funded indications (symptoms associated with carcinoid tumours with features of carcinoid syndrome, VIPomas, glucagonomas, acromegaly, prevention of complications after pancreatic surgery). Red for NHS England indications | Amber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. Red for NHS England indications | |
| Octreotide (off-label indications) | Off-label indications | Red | |
| Ofatumumab | Cancer and pemphigus vulgaris | Red | |
| Olanzapine (IM injection) | Atypical antipsychotic - schizophrenia and bipolar disorders | Red | |
| Olanzapine (oral) | Atypical antipsychotic - schizophrenia and bipolar disorders | Green Specialist Initiation | |
| Olaparib | Treatment of cancers | Red | |
| Olaratumab | Cancer | Red | |
| Olesoxime | Spinal muscular atrophy | Red | |
| Omalizumab | Asthma | Red | |
| Ombitasvir/paritaprevir/ritonavir | Hepatitis C (commissioned by NHS England) | Red | |
| Omega 3 and other fish oils | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Opicapone | For Parkinson's disease | Green Specialist Initiation | |
| Oraldene® gel and mouthwash | Oral hygeine | Red | |
| Osilodrostat | Cushing's disease | Red | |
| Osimertinib | Treatment of cancers | Red | |
| Oxaliplatin | Metastatic colorectal cancer used with 5-FU and folinic acid | Red | |
| Oxcarbazepine | Epilepsy | Green Specialist Initiation | |
| Oxycodone and naloxone MR | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Ozanimod | Multiple sclerosis (MS) | Red | |
| Pacritinib | Myelofibrosis | Red | |
| Palbociclib | Cancer | Red | |
| Paliperidone | Antipsychotic | Red | |
| Palivizumab | Prophylaxis of respiratory syncytial virus (RSV) | Red | |
| Pancreatin preparations | Pancreatic insufficiency | Green Specialist Initiation | |
| Panitumumab | Treatment of cancers | Red | |
| Panobinostat | Treatment of cancers | Red | |
| Para-aminosalicylic acid | TB | Red | |
| Paracetamol and tramadol | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Parathyroid hormone | Specialist endocrinology conditions | Red | |
| Paravit CF Capsules | Cystic Fibrosis | Green Specialist Initiation | 27th November 2019 (n) |
| Paravit CF Capsules | Cholestatic liver disease | Green Specialist Initiation | 27th November 2019 (n) |
| Paricalcitol | Hyperparathyroidism (commissioned by NHS England) | Red | |
| Paromomycin | Treatment of cryptosporidium in immunocompromised patients | Red | |
| Paritaprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Pasireotide | Acromegaly; Cushing's disease | Red | |
| Patiromer (Veltassa®) | Hyperkalaemia | Red | 18th March 2020 (n) |
| Patisiran | Amyloidosis (commissioned by NHS England) | Red | |
| Pazopanib | Treatment of cancers | Red | |
| Pegaspargase | Treatment of cancers | Red | |
| Pegylated liposomal doxorubicin | Treatment of cancers | Red | |
| Peg-filgrastim | Reduction in neutropenia with cytotoxic chemotherapy | Red | |
| Peg-interferon alfa | Treatment of hepatitis B and C | Red | |
| Peginterferon beta-1a | Multiple sclerosis (MS) | Red | |
| Peginterferon lambda-1A | Hepatitis C | Red | |
| Pegunigalsadidase alfa | Fabry's disease (commissioned by NHS England) | Red | |
| Pegvalise | Phenylketonuria (commissioned by NHS England) | Red | |
| Pegvisomant | Acromegaly | Red | |
| Pembrolizumab | Treatments of Cancer | Red | |
| Pemetrexed | Treatment of cancers | Red | |
| Pentosan polysulphate | Interstitial Cystitis | Red | January 2020 (removing unlicensed) |
| Penicillamine | Rheumatology - COVID-19 | Amber Penicillamine - COVID-19 | |
| Penicillamine | Rheumatoid arthritis (RA) | Amber | |
| Peptide receptor radionucelotide therapy | Treatment of cancers | Red | |
| Perampanel | Epilepsy | Green Specialist Initiation | |
| Pergolide | Parkinson's disease | Green Specialist Initiation | |
| Perindopril arginine | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Pertuzumab | Treatment of cancers | Red | |
| Phenelzine | Treatment resistant depression | Amber | |
| Phenol 2% in Zinc paste | Intractable pruritus ani | Red | |
| Phenylbutazone | NSAID - ankylosing spondylitis | Red | |
| Phenylephrine/tropicamide ophthalmic insert (Mydriasert®) | Surgical mydriasis | Red | |
| Phytomenadione capsules | Not licensed in UK | Green Specialist Initiation | |
| Pipotiazine depot injection | Depot antipsychotic for schizophrenia | Green Specialist Initiation | |
| Pibrentasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Pirfenidone | Antifibrotic for idiopathic pulmonary fibrosis | Red | |
| Pivmecillinam | Urinary tract infections | Green | |
| Pixantrone | Treatment of cancers | Red | |
| Plerixafor | Stem cell mobilisation | Red | |
| Pomalidomide | Treatment of cancers. Myelofibrosis | Red | |
| Ponatinib | Treatment of cancers | Red | |
| Ponesimod | Multiple sclerosis (MS) | Red | |
| Poractant alfa | Respiratory distress syndrome | Red | |
| Posaconazole | All indications | Red | |
| Potassium iodide | For treatment of erythema nodosum | Red | |
| Pramipexole | Restless legs syndrome | Green | |
| Pramipexole | Parkinson's disease | Green Specialist Initiation | |
| Pramipexole MR | Parkinson's disease | Green Specialist Initiation | |
| Prasugrel | Cobination with aspirin for the prevention of atherothrombotic events in patients with acute coronory syndrome undergoing percutaneous coronary intervention | Green Specialist Initiation | |
| Prednisone MR | Rheumatoid arthritis (RA) | Black | |
| Pre-exposure prophylaxis (PrEP) | For prevention of HIV in adults. Only as part of a clinical trial. Further details from NHS England who commission this | Black | |
| Prembrolizumab | For adults with relapsed or refractory classical Hodgkin Lymphoma who are stem cell transplant ineligible and have failed on brentuximab vedotin | Red | |
| Pretomanid | Multi-drug resitant TB | Red | |
| Privagen® | All indications | Red | |
| Probiotics | All indications | Black. NHSE items that should not be routinely prescribed in Primary Care | |
| Procarbazine | Treatment of cancers | Red | |
| Propranolol | Paediatric Migraine | Green Specialist Initiation See LTHT guidance for information | |
| Protease inhibitors | HIV infection (commissioned by NHS England) | Red | |
| Protein C | As per BCSH guidelines for specialised indications | Red | |
| Protein kinase inhibitors | Endocrinology; non-malignant conditions | Red | |
| Prothrombin complex | As per BCSH guidelines for specialised indications | Red | |
| Prucalopride | Chronic constipation in women when other laxatives fail to provide an adequate response - NICE TA211 | Green Specialist Initiation | |
| Pyrazinamide | Treatment of TB | Red | |
| Quetiapine | Atypical antipsychotic - schizophrenia | Green Specialist Initiation | |
| Quinidine | Short QT syndrome, Brugada syndrome, and idiopathic ventricular fibrillation (VF) | Red | |
| Quinidine sulphate tablets | Ventricular arrhythmia | Red | 31st July 2019 (n) |
| Rabies vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Radium-223 dichloride | Treatment of cancers | Red | |
| Raltegravir | HIV infection (commissioned by NHS England) | Red | |
| Raltitrexed | Advanced colorectal cancer | Red | |
| Ramucirumab | Treatment of cancers | Red | |
| Ranibizumab | All indications | Red | |
| Ranolazine | Only in accordance with NICE CG126 | Green Specialist Initiation | |
| Rasagiline | Parkinson's disease | Green Specialist Initiation | |
| Rasburicase | Hyperuricaemia | Red | |
| Ravulizumab | Paroxysmal nocturnal haemoglobinuria (commissioned by NHS England) | Red | |
| Raxibcumab | Inhaled anthrax (commissioned by NHS England) | Red | |
| Refanalin | Prevention of delayed graft function (commissioned by NHS England) | Red | |
| Refparixin | Prevention of delayed graft function (commissioned by NHS England) | Red | |
| Regorafenib | Treatment of cancers | ||
| Renavit® | Vitamin supplementation in renal impairment | Green Specialist Initiation | |
| Reslizumab | Asthma | Red | |
| Reveglucosidase alfa | Pompe disease | Red | |
| Ribavirin | Hepatitis C (commissioned by NHS England) | Red | |
| Ribociclib | Cancer | Red | |
| Rifampicin | Treatment of TB | Red | |
| Rifater® (rifampicin/isoniazid/pyrazinamide ) | Treatment of TB | Red | |
| Rifaximin | Treatment of small intestinal bacterial overgrowth and for the treatment of chronic refractory pouchitis | Red | |
| Rifaximin | Prevention of hepatic encephalopathy in adult patients | Green Specialist Initiation | |
| Rifinah® (rifampicin/isoniazid) | Treatment of TB | Red | |
| Rigosertib | Myelodysplastic syndromes (MDS); pancreatic cancer | Red | |
| Rilonacept | Cryopyrin-associated periodic syndromes | Red | |
| Rilpivirine | HIV infection (commissioned by NHS England) | Red | |
| Riluzole | To extend life or time to mechanical ventilation for patients with amyotrophic lateral sclerosis | Amber | |
| Rimeporide | Duchenne muscular dystrophy (commissioned by NHS England) | Red | |
| Rimexolone ophthalmic suspension | Local ocular steroid anti-inflammatory | Green Specialist Initiation | |
| Riociguat | Pulmonary arterial hypertension (CTEPH). Pulmonary arterial hypertension | Red | |
| Risperidone injection | Schizophrenia and other psychoses in patients tolerant to risperidone by mouth | Red | |
| Risperidone oral | Atypical antipsychotic - schizophrenia | Green Specialist Initiation | |
| Ritonavir | HIV infection (commissioned by NHS England) | Red | |
| Ritonavir/lopinavir | HIV infection (commissioned by NHS England) | Red | |
| Rituximab | All uses | Red | |
| Rivipansel sodium | Hepatic veno-occlusive disease (commissioned by NHS England) | Red | |
| Rivaroxaban | See DOACs | See DOACs | |
| Rivastigmine | Mild to moderate dementia in Alzheimer's disease | Green Specialist Initiation | |
| Rivastigmine patches | Mild to moderate dementai in patients with swallowing difficulties | Green Specialist Initiation | |
| Roflumilast | As per TA461: Roflumilast, as an add-on to bronchodilator therapy, is recommended as an option for treating severe chronic obstructive pulmonary disease in adults with chronic bronchitis, only if: •the disease is severe, defined as a forced expiratory volume in 1 second (FEV1) after a bronchodilator of less than 50% of predicted normal, and •the person has had 2 or more exacerbations in the previous 12 months despite triple inhaled therapy with a long-acting muscarinic antagonist, a long-acting beta-2 agonist and an inhaled corticosteroid | Green Specialist Initiation | |
| Romiplostim | Immune (idiopathic) thrombocytopenia | Red | |
| Ropeginterferon alfa-2b | Hepatitis C (commissioned by NHS England) | Red | |
| Ropinirole & ropinirole MR | Parkinson's disease | Green Specialist Initiation | |
| Rotigotine transdermal patches | Parkinson's disease, either used alone or as an adjunct to levodopa with dopa-decarboxylase inhibitor | Green Specialist Initiation | |
| Roxadustat | Dialysis-induced anaemia | Red | |
| Rubefacients (excluding topical NSAIDs) | All indications | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Rucaparib | Primary peritoneal cancer | Red | 18th March 2020 (n) |
| Rufinimide | Epilepsy | Green Specialist Inititation | |
| Ruricotococcog alfa pegol | Haemophilia A (commissioned by NHS England) | Red | |
| Ruxolitinib | Treatment of cancers | Red | |
| Ruzasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Sacrosidase | Treatment of sucrase-isomaltase deficiency (NHS England) | Red | |
| Sacubitril valsartan | According to NICE TA388 for treating symptomatic chronic heart failure with reduced ejection fraction | Green Specialist Initiation | |
| Safinamide | Parkinson's disease, as an adjunct to levodopa alone or in combination with other antiparkinsonian drugs, for mid- to late-stage fluctuations | Green Specialist Initiation | |
| Sandoglobulin® | All indications | Red | |
| Sapropterin | For children with phenylketonuria. Maternal phenylketonuria (NHS England) | Red | |
| Saquinavir | HIV infection (commissioned by NHS England) | Red | |
| Sarilumab | Paediatric indications (where adult NICE TAs are available) | Red | |
| Sarilumab | For moderate to severe active rheumatoid arthritis in adults according to NICE TA485 | Red | |
| Sativex® Oromucosal Spray (cannabis-based product. Delta-9-tetrahydrocannabinol/ cannabidiol ) | Spasticity and neuropathic pain in multiple sclerosis (MS) | Black. Also see information on the DROP-List | |
| Satralizumab | Neuromyelitis optica (commissioned by NHS England) | Red | |
| Saxagliptin | Type 2 diabetes (T2DM) | Green | |
| Sebelipase alfa | Lysosomal acid lipase deficiency | Red | |
| Secukinumab | All indications | Red | |
| Selexipag | Pulmonary arterial hypertension | Red | |
| Semaglutide | Type 2 diabetes | Green | |
| Setrobuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Sevelamer | Hyperphosphataemia in chronic kidney disease patients who may also be on haemodialysis or peritoneal dialysis | Amber | |
| Sialic acid | Myopathy | Red | |
| Sildenafil | Post prostatectomy or radiotherapy | Green Specialist Initiation | |
| Sildenafil | Off-label use for Raynaud's Disease. Pulmonary arterial hypertension | Red | |
| Silicone scar gels and sheets | When the specialist service recommending the treatment is funded by the NHS and has provided NHS funded care for that patient AND • The treatment is for hypertrophic or keloid scars that result from burns, trauma, keloid formation, or surgery and only when one or more of the following clinical criteria are met: a). Scar is functionally disabling b). Scar results in facial disfigurement | Green Specialist Initiation | |
| Silk Garment | For severe eczema and allergic skin conditions. | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Simeprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Siponimod | Multiple sclerosis (MS) (commissioned by NHS England) | Red | |
| Sirolimus | Prophylaxis of organ rejection in transplant patients | Amber | |
| Sirukumab | Paediatric indications (where adult NICE TAs are available) | Red | |
| Sitagliptin | Type 2 diabetes (T2DM) | Green | |
| Sodium aurothiomalate (IM gold) | Rheumatoid Arthritis | Discontinued. | 31st July 2019 (n) Discontinuation letter |
| Sodium benzoate | Urea cycle disorders | Red | |
| Sodium chloride 5% nebuliser solution | Unlicensed | Red | |
| Sodium chloride 7% nebuliser solution (Nebusal®) | For patients with retained bronchopulmonary secretions and where usual treatment is not sufficiently effective | Green Specialist Initiation | |
| Sodium clodronate (IV) | Bisphosphonate – osteolytic lesions, hypercalcaemia and bone pain associated with skeletal masses in breast cancer or multiple myeloma | Red | |
| Sodium hyaluronate (Cystistat®) | Interstitial cystitis | Red | |
| Sodium oxybate | Narcolepsy with cataplexy in children | Red | |
| Sodium phenylbutyrate | Urea cycle disorders | Red | |
| Sofosbuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Sofosbuvir/daclatasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Sofosbuvir/ledipasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Sofosbuvir/velpatasvir | Hepatitis C (commissioned by NHS England) | Red | |
| Somatropin for adults | Acquired adult-onset post-surgery growth hormone deficiency *Please note that Omnitrope® is what we commission in adults as growth hormone product of choice* | Amber | |
| Somatropin for paediatrics | For the treatment of Growth Hormone Insufficiency in Paediatrics | Green Specialist Initiation (see LTHT guidance) | |
| Sorafenib | Treatment of cancers | Red | |
| Spectinomycin | Used as an antibiotic for the treatment of gonorrhoea infections | Red | |
| Stavudine | HIV infection (commissioned by NHS England) | Red | |
| Stiripentol | Rare forms of epilepsy | Red | |
| Streptomycin | Treatment of TB | Red | |
| Strimvelis® | Adenosine deaminase deficiency-severe combined immundeficiency | Red | |
| Subcuvia® | All indications | Red | |
| Subgam® | All indications | Red | |
| Sucroferric oxyhydroxide | Control of serum phosphorus levels in dialysis patients | Red | |
| Sugammadex | Reversal of neuromuscular blockade induced by rocuronium or vecuronium | Red | |
| Sucralfate | All indications | Red | |
| Sulfasalazine | Rheumatology - COVID-19 | Amber Sulfasalazine - COVID-19 | |
| Sulfasalazine | Licensed indication - rheumatoid arthritis (RA). Off-label - other inflammatory arthritides | Amber | |
| Sulfasalazine | Paediatric rheumatology | Amber | |
| Sunitinib | Treatment of cancers | Red | |
| Susoctocog alfa | Haemophilia A | Red | |
| Tabalumab | Systemic lupus erythematosus (SLE) | Red | |
| Tacrolimus (oral) | Immunosuppressant for transplant patients | Amber | |
| Tacrolimus | Post paediatric renal transplant | Amber | |
| Tacrolimus (Adoport®) | Treatment of Crohns Disease unresponsive to other immunosuppressants (off-label use) | Amber | Under review |
| Tacrolimus | Nephrotic Syndrome in children | Amber | |
| Tacrolimus suppositories | Active proctitis | Red | 22nd January 2020 |
| Tacrolimus (topical) | Treatment of moderate to severe atopic dermatitis in adults who are not adequately responsive to or are intolerant of conventional therapies such as topical corticosteroids | Green | |
| Tadalafil | Penile rehabilitation post radical prostatectomy or radiotherapy | Black | |
| Tadalafil once daily | Erectile dysfunction | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Tadalafil | Pulmonary arterial hypertension | Red | |
| Tafamandis | Amyloidosis | Red | |
| Tafluprost | Glaucoma | Green Specialist Initiation | |
| Taliglucerase alfa | Gaucher's disease | Red | |
| Talimogene laherparepvec | Treatment of cancers | Red | |
| Taribavirin | Hepatitis C (commissioned by NHS England) | Red | |
| Tapentadol modified-release tablets | Chronic non-malignant pain | Green Specialist Initiation | |
| Taurine | Cystic fibrosis (CF) management | Amber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| TB drugs | Red when used for TB | Red | |
| Teduglutide | Short bowel syndrome | Red | |
| Tegafur with uracil | Treatment of cancers | Red | |
| Telaprevir | Hepatitis C (commissioned by NHS England) | Red | |
| Telbivudine | Hepatitis B (commissioned by NHS England) | Red | |
| Temozolomide | Treatment of cancers; endocrinology; non-malignant conditions | Red | |
| Temsirolimus | Treatment of cancers | Red | |
| Tenofovir alafenamide | Hepatitis B (commissioned by NHS England) | Red | |
| Tenofovir | HIV infection/hepatits B (commissioned by NHS England) | Red | |
| Tenofovir alafenamide/cobicistat/elvitegravir/emtricitabine | HIV infection (commissioned by NHS England) | Red | |
| Tenofovir disoproxil/cobicistat/elvitegravir/emtricitabine | HIV infection (commissioned by NHS England) | Red | |
| Tenofovir/efavirenz/emtricitabine | HIV infection (commissioned by NHS England) | Red | |
| Tenofovor/emtricitabine/rilpiverine | HIV infection (commissioned by NHS England) | Red | |
| Teriflunomide | Multiple sclerosis (MS) | Red | |
| Teriparatide | All indications | Red | |
| Testosterone gels | Hypogonadism due to testosterone deficiency inn men | Green Specialist Initiation | |
| Testosterone injections (all brands) | Use in line with licensed indications | Green Specialist Initiation | |
| Tetrahydrobiopterin | Phenylketonuria | Red | |
| Tezacaftor | Cystic fibrosis | Red | |
| Thalidomide | All indications | Red | |
| Thrombin | Pseudoaneurysm | Red | |
| Ticagrelor | Antiplatelet drug - use in line with NICE TA236 and TA420 | Green Specialist Initiation | |
| Tick-bourne encephalitis vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Tildrakizumab | Plaque psoriasis in adults | Red | 20th September 2019 (n) |
| Timolol/brinzolamide eye erops (Azarga®) | Glaucoma | Green Specialist Initiation | |
| Tinzaparin | See low molecular weight heparins (LMWH) | See low molecular weight heparins (LMWH) | |
| Tioguanine | Treatment of cancers | Red | |
| Tipranavir | HIV infection | Red | |
| Tisagenlecleucel | Treatment of cancer (commissioned by NHS England) | Red | |
| Tivozanib | Cancer | Red | |
| Tizanidine | Spasticity | Green Specialist Initiation | |
| Tizanidine | Cerebral Palsy Spasticity in Children | Green Specialist Initiation See LTHT guidance for information | |
| Tobramycin (Tobi®) nebuliser solution | Cystic fibrosis (CF) management | Amber | |
| Tobramycin dry powder inhaler | Suppression of chronic pulmonary infections in cystic fibrosis | Red | |
| Tocilizumab | All indications | Red | |
| Tofacitinib | Paediatric indications (where adult NICE TA available) | Red | |
| Tofacitinib | With or without methotrexate for moderate to severe active rheumatoid arthritis (RA) in adults according to NICE TA480. Also for active psoriatic arthritis in adults according to NICE TA543 in combination with methotrexate | Red | |
| Tolvaptan | Hyponatraemia secondary to secretion of inappropriate antidiuretic hormone secretion (SIADH) | Red | |
| Topiramate | Paediatric Migraine | Green Specialist Initiation See LTHT guidance for information | |
| Topotecan | Cancer chemotherapy | Red | |
| Toremifine | Metastatic breast cancer | Green Specialist Initiation | |
| Total parenteral nutrition (TPN) | Intravenous nutrition - various indications | Red | |
| Trabectedin | Treatment of cancers | Red | |
| TraLife® oral spray | Oral hygeine | Red | |
| Tralokinumab | Asthma | Red | |
| Trametinib | Treatment of cancers | Red | |
| Trastuzumab | Treatment of cancers | Red | |
| Trastuzumab emtansine | Treatment of cancers | Red | |
| Travel vaccines | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Travoprost/timolol (Duotrav®) | Rasied intra-ocular pressure | Green Specialist Initiation | |
| Trenonacog alpha | Haemophilia B | Red | |
| Treosulfan | Treatment of cancers | Red | |
| Treprostinil diethalamine | Pulmonary arterial hypertension | Red | |
| Treprostinil sodium | Pulmonary arterial hypertension | Red | |
| Tretinoin (oral) | Antineoplastic; induction of remission in acute promyelocytic leukaemia | Red | |
| Triamcinolone hexacetonide (Lederspan®) | Unlicensed - depot steroid injection for use in children | Red | |
| Triheptanoin | Pyruvate carboxylase deficiency (commissioned by NHS England) | Red | |
| Trientine | Wilson's disease | Red | |
| Trifluridine/tipiracil | Treatment of cancers | Red | |
| Trimipramine | For all indications | Black for new patients NHSE items that should not be routinely prescribed in Primary Care | |
| Triptorelin | Endometriosis or uterine fibroids | Amber - see GnRH analogues | |
| Triptorelin | IVF treatment; male hypersexuality | Red | |
| Triptorelin | Precocious puberty | Amber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements. | |
| Triptorelin | Management of prostate cancer | Amber - see GnRH analogues | |
| Trospium MR | Urinary incontinence | Green | |
| Trospium XL | Urinary incontinence | Green | |
| Tryptophan | Severe disabling depression. Unlicensed product - named patient use only | Red | |
| Turotocog alfa | As per BCSH guidelines | Red | |
| Ulipristal 5mg | 1. Pre-operative management of uterine fibroids. Alternative treatment to hysterectomy, myomectomy, uterine embolization or GnRH agonists in perimenopausal patients with moderate to severe symptoms caused by fibroids. Also considered in younger patients with high surgical/anaesthetic risks. 2. Intermittent treatment of moderate to severe symptoms of uterine fibroids | Red | |
| Ultibro Breezhaler® | Chronic obstructive pulmonary disease (COPD) | Green | |
| Uprifosbuvir | Hepatitis C (commissioned by NHS England) | Red | |
| Urofollitropin | IVF treatment | Red | |
| Ustekinumab | All indications | Red | |
| Vadadustat | Dialysis-induced anaemia | Red | |
| Valaciclovir | For the treatment of Herpes Simplex Virus (HSV) Encephalitis in Paediatrics | Green Specialist Initiation See LTHT guidance for information | |
| Valganciclovir | All indications | Red | |
| Valproate | All indications | Green Specialist Initiation | |
| Vandetanib | Thyroid cancer | Red | |
| Vardenafil | Penile rehabilitation post radical prostatectomy or radiotherapy | Black | |
| Vatiquinone | Friedreichs ataxia (commissioned by NHS England) | Red | |
| Vedolizumab | All indications | Red | |
| Velaglucerase alfa | Gaucher's disease | Red | |
| Velcalcetide | Hyperparathyrodism | Red | |
| Velmanase alfa | Alpha mannosidase deficiency (commissioned by NHS England) | Red | |
| Vemurafenib | Melanoma | Red | |
| Venetoclax | Cancer | Red | |
| Venlafaxine (at doses over 300mg daily) | Treatment of major depressive episodes. For prevention of recurrence of major depressive episodes. Treatment of generalised anxiety disorder. Treatment of social anxiety disorder. Treatment of panic disorder, with or without agoraphobia | Green Specialist Initiation | Updated 17.02.2020 |
| Verteporfin | Age related macular degeneration | Red | |
| Vestronidase alfa | Mucopolysaccharidosis VII (commissioned by NHS England) | Red | |
| Vibropulse | Cellulitis, venous leg ulcers and lower limb oedema | Black | 22nd January 2020 (n) |
| Viekirax® | Hepatitis C (commissioned by NHS England) | Red | |
| Vigam® | All indications | Red | |
| Vildagliptin | Type 2 diabetes (T2DM) | Green | |
| Vildagliptin with metformin | Type 2 diabetes (T2DM) | Green | |
| Vinblastine | Treatment of cancers | Red | |
| Vincristine | Treatment of cancers | Red | |
| Vindesine | Treatment of cancers | Red | |
| Vinorelbine | Treatment of cancers | Red | |
| Vismodegib | Treatment of cancers | Red | |
| Vitamin A | Retinosa pigmentosa | Red | |
| Vivaglobin® | All indications | Red | |
| Volanesorsen | Familial chylomicronemia syndrome (commissioned by NHS England) | Red | |
| Volulyte® injection | Plasma expander | Red | |
| Von Willebrand factor, recombinant | Von Willebrand deficiency | Red | |
| Vonicog alfa | Von Willebrand deficiency (commissioned by NHS England) | Red | |
| Voretigene neparvovec | Lebers disease (commissioned by NHS England) | Red | |
| Voretigene neparvovec | Inherited retinal dystrophies (commissioned by NHS England) | Red | |
| Voriconazole | Fungal infections. Chronic pulmonary aspergillosis | Red | |
| Vortioxetine | For treating major depressive episodes | Green Specialist Initiation | |
| Voxelotor | Sickle cell disease (commissioned by NHS England) | Red | |
| VX-210 | Spinal cord injury (commissioned by NHS England) | Red | |
| Xonvea® | Nausea and vomiting in pregnancy | Black not yet classified | |
| Yellow fever vaccine | For travel use | Black NHSE items that should not be routinely prescribed in Primary Care | |
| Ziconotide | Non-opioid analgesic administered by intrathecal infusion | Red | |
| Zidovudine | HIV infection (commissioned by NHS England) | Red | |
| Zidovudine/lamivudine | HIV infection (commissioned by NHS England) | Red | |
| Zidovudine/lamivudine/abacavir | HIV infection (commissioned by NHS England) | Red | |
| Zoledronic acid | Prevention of skeletal related events (pathological, spinal compression, radiation/surgery to bone, or tumour-induced hypercalcaemia) in patients with advanced malignancies involving bone; treatment of tomour-induced hypercalcaemia | Red | |
| Zuclopenthixol depot injection | Depot antipsychotic for schizophrenia | Green Specialist Initiation |