Search by individual drug

*The Area Prescribing Committee may accept shared care guidelines that have been produced by other organisations.

Drug or DeviceIndicationsClassificationAPC Date or Other
(n) = New
(a) = Amendment
3C PatchFor treating diabetic foot ulcersDo not prescribe/not yet classifiedWY ICS APC November 2022
3,4-diaminopyridineLambert-Eaton myasthenic syndrome (LEMS) (commissioned by NHS England)Red
5-Aminolaevulinic Acid gel (78mg/g)For dermatology for treatment of actinic keratosis of mild to moderate severity (Olsen grade 1 and 2) and of field cancerization in adults – Treatment of superficial and/or nodular basal cell carcinoma unsuitable for surgical treatment due to possible treatment-related morbidity and/or poor cosmetic outcome in adults.RedWY ICS APC March 2023 (n)
5-methoxypsoralenPUVA treatment of psoriasisRed
AbacavirHIV infection (commissioned by NHS England)Red
Abacavir/dolutegravir/lamivudineHIV infection (commissioned by NHS England)Red
Abacavir/lamivudineHIV infection (commissioned by NHS England)Red
AbataceptAll indications Red
Abatacept subcutaneous or intravenous injectionFor morphoea (localised scleroderma) in adultsRedWY ICS APC Chair's action January 2022.
AbemacicibFor treating hormone receptor-positive human epidermal growth factor receptor 2 (HER2) - negative locally advanced or metastatic breast cancerRedWY ICS APC April 2022
AbemaciclibTreatment of cancer (commissioned by NHS England)Red31st July 2019 (n)
AbirateroneFor use in treatment of cancer (Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned - see specialist advice)RedWY ICS APC November 2022 (a)
AbrocitinibFor treating moderate to severe atopic dermatitis NICE TA814RedWY ICS APC November 2022
AcalabrutinibFor chronic lymphocytic leukaemiaRed28th July 2021 (n)
AcamprosateMaintain abstinence in alcohol-dependent patientsAcamprosateMarch 2021 (a)
Acarovac Plus s/c injectionFor allergic diseases caused by house dust mite (unlicensed)RedWY ICS APC Nov 2023
Acetylcysteine (unlicensed preparations)For idiopathic pulmonary fibrosisDo not prescribeWY ICS APC Nov 2023 (a)
Acetylcysteine nebulisedFor treating cystic fibrosis in adults and childrenDo not prescribeWY ICS APC Nov 2023
AcetylcysteineCOPDGreen31st July 2019 (n)
AcitretinOral retinoid for psoriasisRed
Aclidinium bromide powder inhaler Chronic obstructive pulmonary disease (COPD)Green
ActimorphFor the management of breakthrough pain in patients at risk of overdose (either intentional or unintentional), patients with dexterity and cognition issues or patients unable to tolerate other forms of morphineGreen RestrictedWY ICS APC November 2022
Actipatch®PainBlack not yet classified
AdalimumabAll indications Red
Adaliumab injectionFor moderate rheumatoid arthritisRedWY ICS APC 20th October 2021 (n)
AfatinibTreatment of cancer (commissioned by NHS England)Red
AfliberceptAll indicationsRed
Agalsidase alfaFabry's disease (commissioned by NHS England)Red
Agalsidase beta
Fabry's disease
(commissioned by NHS England)
Red
AgomelatineFor the treatment of depression in adultsAgomelatineWY ICS APC Sept 2023
Albumin-bound paclitaxelTreatment of cancer (commissioned by NHS England) Red
Albutropin
Adult onset growth hormone deficiency
(NHS England)
Red
Aldesleukin
Treatment of cancers
(NHS England)
Red
AlectinibTreatment of cancer (commissioned by NHS England)
Red
AlemtuzumabAll indications
Red
Alglucosidase alfa
Pompe disease
(commissioned by NHS England)
Red
AlirocumabFor treating adults with high cholesterol levels in their blood NICE TA393RedWY ICS APC November 2033
AliskirenFor treating hypertensionDo not prescribeWY ICS APC Sept 2023
AlitretinoinSevere chronic hand eczema refractory to potent topical corticosteroidsRed
Alogliptin Type 2 diabetes (T2DM) Green
Alpelisib tablet in combination with fulvestrantFor HR positive HER2 negative breast cancerRedWY ICS APC 22nd June 2022
Alprostadil creamErectile DysfunctionGreen Specialist Initiation18th March 2020 (n)
AlteplaseThrombolyticRed
AmbrisentanPulmonary arterial hypertension (commissioned by NHS England)Red
AmiodaroneTreatment of Ventricular and Supraventricular Arrhythmias for Adult Patients AmiodaroneWY ICS APC May 2023
Amifampridine
Lambert-Eaton myasthenic syndrome (LEMS) (NHS England)
Do not Prescribe
AmikacinTreatment of bacterial infections in adult and paediatric patientsRedWY ICS APC 24th May 2023
Amikacin inhalation
Cystic fibrosis (CF)
Red
Amikacin liposomal
Cystic fibrosis (CF)
Red
Amphotericin liposomal
Fungal infections
Red
AmisulprideAtypical antipsychotic for schizophreniaGreen Specialist Initiation
AnagrelideEssential thrombocythaemiaRed
AnakinraAll indicationsRed
Anakinra SC injectionFor Haemophagoncytic Lymphohistiocytosis (HLH) for adults and children in all agesRedWY ICS APC 22nd June 2022
AnastrozoleBreast Cancer - long term therapyGreen Specialist Initiation
AndexanetFor reversing anticoagulation from apixaban or rivaroxaban NICE TA697RedWY ICS APC April 2022
AnidulafunginIV antifungal agentRed
Anoro Ellipta 55/22®Chronic obstructive pulmonary disease (COPD)Green
Antacid and OxetacaineFor radiotherapy induced oesophagitis (ULM)RedWY ICS APC November 2022
Anti-epileptic drugs (AED) in childrenSee LTHT guidance for information Green Specialist Initiation
Antihistamines for hay fever (OTC or prescription)For treatment of mild to moderate hay feverBlack28th July 2021(a)
Antihaemophilic factor/Von Willebrand factor complex
As per BCSH guidelines for specialised indications
Red
Antilymphocyte globulin
Aplastic anaemia organ transplant
Red
Antithrombin III
As per BCSH guidelines for specialised indications
Red
Antithymocyte immunoglobulin
Aplastic anaemia organ transplant
Red
Anti-retroviralsHIV infection (commissioned by NHS England)Red
Antox®Anti-oxidant therapy for pancreatitisGreen Specialist Initiation
ApalutamideFor treating high-risk hormone-relapsed non-metastatic prostate cancer and for treating hormone-sensitive metastatic prostate cancer NICE TA740 & TA741RedWY ICS APC April 2022
Apixaban See DOACsSee DOACs
ApixabanFor the prevention of venous thrombo-embolism (VTE) in patients with multiple myeloma (ULM)RedWY ICS APC Nov 2023
ApomorphineParkinson's disease Green Specialist Initiation
ApraclonidineShort-term adjunctive therapy of chronic glaucoma in patients on maximally tolerated medical therapy who require additional intraocular pressure (IOP) reduction to delay laser treatment or glaucoma surgery. On advice from ophthalmology only with clear instruction on duration of treatment and plan for follow up.Specialist Initiation RestrictedWY ICS APC November 2022
Apremilast
According to NICE (TA433) for the treatment of active psoriatic arthritis & (TA419) for treating moderate to severe plaque psoriasis
Red
Apremilast
Paediatric indicationsRed
AprepitantNausea/vomiting with highly emetogenic chemotherapyRed
Aragam®All indicationsRed
Aripiprazole (oral)SchizophreniaGreen Specialist Initiation31st July 2019 (a)
Aripiprazole injectionSchizophreniaRed31st July 2019 (n)
Arsenic trioxide
Treatment of cancer (commissioned by NHS England)
Red
Artemether with lumefantrineFor the treatment of acute uncomplicated Plasmodium falciparum malaria in-line with national guidance.RedWY ICS APC July 2023.
ArtesunateTreatment of severe malariaRed22nd January 2020
AsciminibFor treating chronic myeloid leukaemia after 2 or more tyrosine kinase inhibitors NICE TA813RedwY ICS APC November 2022
AsenapineTreatment of bipolar disordersRed WY ICS APC Jan 2024
Asfotase alfaHypophosphatasiaRed
Ataluren
Duchenne muscular dystrophy
Red
AtazanavirHIV infection (commissioned by NHS England)Red
Atazanavir/cobicistatHIV infection (commissioned by NHS England)Red
AtezolizumabTreatment of cancer (commissioned by NHS England)
Red
Atezolizumab concentrate for solution for infusionFor adjuvant treatment following complete resection for adult patients with Stage II to IIIA non-small cell lung cancer whose tumours have PD-L 1 expression.RedWY ICS APC 22nd June 2022
AtovaquoneTreatment of mild to moderate Pneumocystis jirovecii pneumonia in patient’s intolerant of co-trimoxazole. Use for prophylaxis against pneumocystis pneumonia. Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist adviceRedWY ICS APC March 2023 (n)
Atropine Eye DropsFor delaying the progress of myopia in childrenRedWY ICS APC March 2023 (n)
Atropine Eye dropsFor treatment of hypersalivation (unlicensed use)GreenWY ICS APC March 2023 (n)
Autologous chrondocyte implantationArticular cartilage defectRed
Autologous serum eye drops
Dry eyeRed
AtomoxetineFor attention deficit hyperactivity disorder (ADHD) in school-age children, adolescents and adultsAmberCurrently under RMOC consultation and will update accordingly - July 2021
AvacopanTreatment of adult patients with severe, active granulomatosis with polyangiitis NICE TA825RedWY ICS APC November 2022
AvanafilPenile rehabilitation post radical prostatectomy or radiotherapyBlack
Avanafil Erectile dysfunction in adult males Green
AvastinFor neovascular glaucoma and neovascularization of the retinaRed
AvatrombopagFor treating severe thrombocytopenia in adults with chronicliver disease having planned invasive proceduresRedWY ICS APC April 2022
Avelumab
Treatment of cancer (commissioned by NHS England)
Red
Avelumab solution for infusionFor untreated metastic Merkel cell carcinomaRedWY ICS APC Chair's action January 2022.
Axicabtagene ciloleucel
Treatment of cancer (commissioned by NHS England)
Red
Axitinib
Treatment of cancer (commissioned by NHS England)Red
AzacitidineTreatment of cancer (commissioned by NHS England)Red
Azathioprine 75mg and 100mg tablets (new strengths)Indicated in immunosuppressive regimens. Concerns these new strengths could lead to overdose as they have bnot been available in the UK before.Do not Prescribe/Not yet ClassifiedWY ICS APC Jan 2024
AzathioprineTransplant immunosuppressionAmber
Search for azathioprine/a>
Currently under RMOC consultation and will update accordingly - July 2021
Azathioprine Paediatric Inflammatory Bowel Disease (IBD) / Rheumatology Amber Currently under RMOC consultation and will update accordingly - July 2021
Azathioprine and mercaptopurineFor patients within adult sevices (non-transplant indications).AmberW ICS APC July 2023.
Azithromycin Long term treatment bronchiectasis & COPDGreen Specialist Initiation
Azithromycin eye dropsPurulent bacterial conjunctivitisRed29th July 2020 (n)
Azithromycin 15mg/g (1.5%) eye dropsFor the treatment of blepharitis in adults and childrenSpecialist InitiationWY ICS APC November 2022
Aztreonam lysineCystic fibrosis (CF) PatientsRed20th September 2019 (a)
Baricitinib
Moderate to severe active rheumatoid arthritis in adults who have responded inadequately, or intolerant to one or more DMARDsRed
BaricitinibRestricted use for systemic autoinflammatory syndromeRedWY ICS APC September 2022
BaricitinibTreatment of moderate to severe atopic dermatitis in adults who are candidates for systemic therapy.Red22nd September 2021 (n)
BaricitinibTreatment of patients aged 18 years with severe alopecia areata, including alopecia totalis and alopecia universalis (licence extension) - new indicationDo not prescribe/not yet classifiedWY ICS APC November 2022
Baricitinib
Paediatric indications (where adult NICE TA available)
Red
Baricitinib tablets (2mg and 4mg)For monogenic interferonopathies (Adults and children 2 years and older)RedWY ICS APC March 2022 (n)
Basiliximab
Renal transplant
Red
Bath and Shower preparationsDry and pruritis skin conditionsDo not prescribeWY ICS APC November 2022
BCG vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
BedaquilineTBRed
BelimumabSystemic lupus erythematosus (SLE)Red
Bempedoic acid with ezetimibe tabletsFor the treatment of primary hypercholesterolaemia or mixed dyslipidaemia when taken in combination with ezetimibe as per NICE TA694.Green RestrictedWY ICS APC 24th May 2023
Bempedoic Acid monotherapyUse in adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet, only in exceptional patients who are intolerant to other lipid lowering medicines.Specialist RecommendationWY ICS APC Sept 2023
BendamustineTreatment of cancer (commissioned by NHS England)Red
Benralizumab
Asthma
Red
BenzbromaroneUnlicensed medicine - Gout Red
Berotralstat dihydrochloride hard capsules (150mg)Indicated for routine prevention of recurrent attacks of hereditary angioedema (HAE) in adult and adolescent patients aged 12 years and older. NICE TA738RedWY ICS APC March 2022 (n)
BerotralstatFor preventing recurrent attacks of hereditary angioedema NICE TA738RedWY ICS APC April 2022
Betaine
Homocystinuria
Red
Bevacizumab All indicationsRed
BexaroteneTreatment of cancersRed
BezafibrateFor treatment of Primary Biliary Cholangitis Specialist Initiation with additional guidanceWY ICS APC Sept 2023
BicalutamideLocally advanced prostate cancer at high risk of disease progression.
Locally advanced non-metastatic prostate cancer when surgical castration or other medical intervention inappropriate.
Ongoing monotherapy for prostate cancer in patients wishing to preserve sexual function.
Maximum androgen blockade – use continuously in conjunction with LHRH analogue for three months
Amber
Bimatoprost/timolol eye drops (Ganfort®)GlaucomaGreen Specialist Initiation
Bimekizumab 160mg solution for injection in pre-filled pen/syringeFor all indicationsRedWY ICS APC Nov 2023 (a)
BinimetinibTreatment of cancersRed4th Sept 2020
Biopatch®Prevention of catheter site infectionRed
BiotinVitamin induced hair loss. Multiple sclerosis (MS)Red
Bismuth SubsaliylateMicroscopic colitisSpecialist RecommendationWY ICS APC September 2022
Bismuth subsalicylate tabletsFor treatment of H pyloriGreenWY ICS APC November 2022
BivalirudinFor the treatment of Acute Coronary Syndrome in line with NICE NG185.RedWY ICS APC 24th May 2023
BlinatumomabTreatment of cancersRed
BoceprevirHepatitis C (commissioned by NHS England)Red
Bone morphogenic protein (dibotermin, eptotermin)Complex spinal surgery
(commissioned by NHS England)
Red
Bortezomib
For Waldenstrom's Macroglobulinemia
RedWY ICS APC April 2022
BosentanAll indicationsRed
Bosutinib
Treatment of cancer (commissioned by NHS England)
Red
Botulinum toxinAll indicationsRed
Botulinum toxin injectionFor cricopharyngeal spasm in laryngectomy patientsRedWY ICS APC Chair's action January 2022.
Brentuximab
Treatment of cancer (commissioned by NHS England)Red
Brexucabtagene autoleucelFor treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 26 years and over.RedWY ICS APC July 2023
Brigatinib
Treatment of cancer (commissioned by NHS England)
Red
Brimonidine gelTreatment of facial erythema of rosacea in adultsBlack
BrivaracetamAs an adjunctive third line treatment option for the management of partial-onset seizures with or without secondary generalisation in adults. Brivaracetam may be considered if there is:
• failure of one or more first line drugs (carbamazepine, lamotrigine or levetiracetam) AND
• failure of one or more 2nd line drugs (topiramate, pregabalin, lacosamide, zonisamide or perampanel)
Green Specialist Initiation
BrivaracetamPartial onset seizures - for paediatric useGreen Specialist Initiation20th September 2019 (n)
BrodalumabPaediatric indications (where adult NICE TA available)
Red
BrodalumabFor moderate to severe plaque psoriasis in adults according to NICE TA511Red
Brolucizumab 120mg/ml solution for injection intravitreal injectionLicensed for the treatment of neovascular (wet) age-related macular degeneration (AMD)
NICE TA672
RedWY ICS APC March 2022 (n)
Budesonide nebuliser liquidFor the treatment of paediatric oesinophilic oesophagitis. .How to make up the liquidSpecialist Initiation with additional guidanceWY ICS APC November 2022
Budesonide 1mg orodispersible tabletsFor eosinophilic in adults - for short courses upto 6 weeks for an acute episode NICE TA708RedWY ICS APC November 2022
Budesonide 1mg orodispersible tabletsFor eosinophilic in adults - maintenance course NICE TA708Specialist RecommendationWY ICS APC November 2022
Budesonide orodisperisable tabletsFor treatment of eosinophilic esophagitis (EoE) in adultsRedWY ICS APC November 2022
Budesonide orodisperiable tabletsFor all indications other than treatment of acute or maintenance of oeosinophilic oesophagitisDo not precribeWY ICS APC November 2022
Budesonide MMX (Cortiment)In adults for induction of remission in patients with mild to moderate active ulcerative colitis (UC) where 5-ASA treatment is not sufficientRed24th March 2021 (n)
Budesonide Prolonged Release (Cortiment®) 9mg tabletFor use in ulcerative colitis - requesting a supply during a flare up in line with patients' self-management plan,, maximum 2 courses per year.Specialist RecommendationWY ICS APC Nov 2023
BulevirtideIndicated for the treatment of chronic hepatitis delta virus (HDV) infection in plasma (or serum) HDV-RNA positive adult patients with compensated liver diseaseRedWY ICS APC July 2023
BulkamidPeriurethral injection for the management of female stress incontinenceRed
Buprenorphine implantFor substitution treatment for opioid dependence in clinically stable adult patients who require no more than 8mg/day of sublingual buprenorphine. This formulation has yet to be reviewed at WY ICS level.Do Not Prescribe/Not yet classifiedWY ICS PC March 2023 (n)
Buprenorphine prolonged release solution for injectionTreatment of opioid dependence within a framework of medical, social and psychological treatment – adults and adolescents aged 16 years or over.RedWY ICS APC March 2023 (n)
Burosumab
X-linked hypophosphataemiaRed
BuserelinGonadorelin analogue - IVFRed
BusulfanTreatment of cancerRed
C1 esterase inhibitorsHereditary angioedema
Red
CabazitaxelTreatment of cancer (commissioned by NHS England)Red
Cabotegravir with RilpivirinFor HIV-1 infection in adults NICE TA757RedWY ICS APC 22nd June 2022
CabozantinibTreatment of cancer (commissioned by NHS England)Red
Canakinumab
Cryopyrin associated periodic syndrome and juvenile arthritis - paediatric
Red
CabergolineParkinson's diseaseGreen Specialist Initiation
CalcifediolVitamin D deficienciesDo not Prescribe/Not yet ClassifiedWY ICS APC Jan 2024
Calcipotriol /
betamethasone scalp gel
Psoriasis Green
Canagliflozin Type 2 diabetes (T2DM) Green
Cannabis-based products (not Sativex®) See NHS England's Guidance Cannabis-based products
Black
Cannabidiol (Epidyolex®) with clobazam
Dravet/Lennox gestaut syndromeRed
Cannabidiol oral solutionAll licensed indicationsRedWY ICS APC 20th October 2021 (n)
CapecitabineAll indicationsRed
Caphosol® oral rinse For the prevention and treatment of mucositis caused by high dose chemotherapyRed
CaplacizumabThrombotic thrombocytopenic pupuraRed4th Sept 2020
Capsaicin patches 8%Neuropathic painRed
Captopril liquid 5mg/5ml and 25mg/5mlFor all licensed indications and Neonatal Unit and congenital heart disease patients. Green for adults with swallowing difficulties (use most cost-effective product).Specialist RecommendationWY ICS APC Sept 2023
Captopril liquid 5mg/5ml and 25mg/5mlFor all licensed indications for adults with swallowing difficulties. Specialist Recommendation for all licensed indications and neonatal unit and congenital heart disease patients.GreenWY ICS APC Sept 2023
Carfilzomib
Treatment of cancer (commissioned by NHS England)Red
Carglumic acid
Urea cycle disorders
Red
Carnitine
Carnitine deficiency
Red
Carnoys solutionTreatment of histological odentogenic keratocysts or recurrencesRed22nd January 2020 (n)
Casirivimab with imdevimabFor intravenous infusion or subcutaneous injection for treating COVID-19 diseaseRedWY ICS APC Chair's action January 2022.
Caspofungin
Fungal infections
Red
CefiderocolMulti-drug resistant aerobic gram negative infections on advice of microbiologyRedWY ICS APC September 2022
CemiplimabTreatment of CancersRed4th Sept 2020
CeritinibAll indicationsRed
Cerliponase alfa
Neuronal ceroid lipofuscinosis
Red
Certolizumab pegolAll indicationsRed
CetrorelixIVFRed
CetuximabTreatment of cancer (commissioned by NHS England)Red
Chenodeoxycholic acid
Cerebrotendinous xanthomatosis and primary biliary cirrhosis
Red
Chloral Hydrate Insomnia (Short term use)Red
Chloral Hydrate (oral)For paediatric neurology and palliative careGreen Specialist Initiation
ChlorambucilBenign angiitis of the CNSRed
ChlordiazepoxideAcute alcohol withdrawalRed
Chlormethine 160mg/g gelTopical treatment of mycosis fungoides-type cutaneous T-cell lymphoma in adults
NICE TA720
RedWY ICS APC March 2022 (n)
Cholic acidInborn errors in primary bile acid synthesisRed
ChondroitinAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
Chondriotin sulphateBladder instillation for Patients with damaged or glycosaminoglycan deficient bladder epitheliumRed
Chorionic gonadotrophinGonadorelin analogue - IVFRed
CiclosporinInflammatory bowel diseaseAmber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
CiclosporinLicensed indications: rheumatoid arthritis, psoriasis.
Off-label indication: psoriatric arthritis
Amber
CiclosporinDermatological conditions. Licensed: atopic dermatitis. Off-label: bullous pemphigoid, pyoderma gangrenosum, hidradenitis suppurativa, pemphigus & lupusAmber
CiclosporinBone marrow transplantAmber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
Ciclosporin Paediatric RheumatologyAmber
Ciclosporin Post-transplantAmber
Ciclosporin eye drops 1mg/mL (0.1%) (Verkazia)Treatment of severe Vernal Keratoconjunctivitis (VKC) in children from 4 years to adolescents - licensedSpecialist InitiationWY ICS APC November 2022
Ciclosporin eye drops 1mg/ml (Ikervis®)For severe keratitis in adult patients with dry eyes as per NICE TA369Specialist InitiationWY ICS APC March 2023 (n)
CidofovirCytomegalovirus Red
CinacalcetHypercalcaemia of primary hyperparathyroidism or parathyroid carcinoma Amber CinacalcetWY ICS APC November 2022 (a)
CinacalcetSecondary hyper-parathyroidism in patients with end-stage renal disease on maintenance dialysis therapyAmber
Cipaglucosidase alfaFor treating late onset Pompe disease (with migluslat) NICE TA912RedWY ICS APC Nov 2023
Cisplatin 1mg/ml injectionFor nasopharyngeal cancerRedWY ICS APC March 2022 (n)
Cladribine
Multiple sclerosis (MS) Red
ClofarabineTreatment of cancer (commissioned by NHS England)Red
ClofazimineAntimycobacterialRedWY ICS APC November 2022
ClomifeneIVF treatmentRed
Clonidine patchesFor children with ongoing new developmental problems including dystonia. Please note that patches were previously Specialist Initiation (Amber 2) in Leeds, unclassified in South West Yorkshire. Guidance on the use for dystonia in children is being updated to reflect this change. Oral preparations for dystonia remain specialist initiation. Please note these classifications only apply to the use of clonidine in dystonia. There are other indications for clonidine - see local formularies.RedWY ICS APC March 2023 (n)
Clopidogrel For all licensed indicationsGreen WY ICS APC 24th May 2023
ClozapineAtypical Antipsychotic - SchizophreniaRed
CoaguCheKFor paediatric haematology - Peadiatric haematology patients managed by the Leeds anticoagulant service only.Specialist Initiation RestrictedWY ICS APC 24th May 2023
CoaguChekFor adults who are on long-term vitamin K antagonist therapy wh have atrial fibrillation or heart valve diseaseRedWY ICS APC 24th May 2023
CobicistatHIV infection (commissioned by NHS England)Red
Co-careldopa intestinal gelSevere Parkinson's diseaseRed
Co-Enzyme Q10Enzyme deficiency in childrenRed
ColesevelamHyperlipidaemiaGreen
ColesevelamFor pruritus in liver disease - unlicensed. Unlicensed for the treatment of bile acid malabsorptionSpecialist RecommendationWY ICS APC April 2022
ColestilanRenal dialysis - adultsRed
Colestyramine sachetsFor pruritus in liver disease (historic use)GreenWY ICS APC Chair's action January 2022.
Colief® dropsColicBlack30th September 2020(a)
Colistimethate sodium - (Colomycin®)Cystic fibrosis (CF) managementAmber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
Colistimethate sodium - (Promixin®)Cystic fibrosis (CF) managementAmber
Colistimethate sodium - (Colomycin®)Pseudomonas infection in the lungs Amber
Conestat alfaHereditary angioedemaRed
Co-proxamolAll indications
Black
NHSE items that should not be routinely prescribed in Primary Care
Cough and cold remediesFor treating coughs and colds unless the patient meets one or more of the exception critieria.Do Not PrescribeWY ICS APC Nov 2023 (a)
Crizanlizumab
Indicated for the prevention of recurrent vaso-occlusive crises (VOCs) in sickle cell disease patients aged 16 years and older. It can be given as an add-on therapy to hydroxyurea/hydroxycarbamide (HU/HC) or as monotherapy in patients for whom HU/HC is inappropriate or inadequateRedWY ICS APC March 2022 (n)
Crizotinib
Treatment of cancer (commissioned by NHS England)Red
Cyanocobalamin (oral)For the treatment of vitamin B12 deficiency, pernicious anaemia associated with vitamin B12 deficiency.GreenWY ICS APC 24th May 2023
Cyclophosphamide All Indications Red
CyproheptadineFor use as an appetite stimulant in paediatric patientsRedWY ICS APC Jan 2024
CyproteroneProstate cancer and male hypersexuality.
Red for new patients
Amber for existing patients only
Amber
Cyproterone (off-label indications)Off-label indicationsRed
CyproteroneAnti-androgen for gender dysphoriaAmber
LHTH
20th September 2019 (n)
Cysteamine (mercaptamine)Nephropathic cystinosisRed
Cytisine oralUsed in the treatment of smoking cessationDo not Prescribe/not yet classifiedWY ICS APC Jan 2024
Cytotoxic injectable drugsAll indicationsRed
DabigatranSee DOACsSee DOACs
Dabrafenib Treatment of cancerRed
DabrafenibFor histiocytic disordersRedWY ICS APC April 2022
DaclatasvirHepatitis C (commissioned by NHS England)Red
Daclizumab
Multiple sclerosis (MS)
Red
DacomitinibTreatment of cancersRed4th Sept 2020
DalbavancinAcute bacterial skin and skin structure infections in adultsRed24th March 2021 (n)
Danazol (unlicensed)Aplastic anaemiaRed29th July 2020 (n)
DanazolThe treatment of Hereditary Angioedema (HAE) Amber
LTHT guidance
July 2021 (n)
Dapagliflozin Type 2 diabetes (T2DM)Green
DapagliflozinFor treating chronic heart failure with preserved or mildly reduced ejection fraction. In line with NICE TA902. Please note: This drug must be recommended by a specialist with the relevant experience/expertise and may not necessarily be a prescriber.Specialist RecommendationWY ICS APC Nov 2023 (a)
DapagliflozinFor treating chronic heart failure with reduced ejection fraction. In line with NICE TA679. Please note: This drug must be recommended by a specialist with relevant experience/expertise and may not necessarily be a prescriber.Specialist RecommendationWY ICS APC Nov 2023 (a)
DapagliflozinFor treating chronic kidney disease – NICE TA775Green RestrictedWY ICS APC 22nd June 2022
Dapagliflozin For children under 10 years with CKD and proteinuriaDo Not PrescribeWY ICS APC Nov 2023
Dapagliflozin For children 10 years old up to puberty with CKD and proteinuriaRedWY ICS APC Nov 2023
DapagliflozinFor children post puberty until 18 years with CKD and proteinuria.Specialist InitiationWY ICS APC Nov 2023
DapoxetinePremature ejaculationBlack
DapsoneLicensed indication- Dermatitis herpetiformis, and off-label indications - dermatoses (leucocytoclastic vasculitis, Sweet's syndrome, pyoderma gangrenosum)SWYAPC31st July 2019 (a)
DaratumunabTreatment of cancer (commissioned by NHS England)Red31st July 2019 (n)
DaratumumabAll oncology indicationsRedWY ICS APC Jan 2024
DaratumumabFor transplant eligible, newly diagnosed myeloma in combination with thalidomide and dexamethasoneRedWY ICS APC September 2022
Daratumumab plus bortezomib, thalidomide and dexamethasoneAs induction and consolidation treatment for untreated multiple myeloma in adults, when an autologous stem cell transplant is suitable NICE TA763RedWY ICS APC April 2022
Darbepoetin alfaAll indications Red
DaridorexantFor treating long-term insomnia in line with NICE TA922 (Insomnia pathway in development)Green RestrictedWY ICS APC Nov 2023
DarolutamideTreatment of adult men with non-metastatic castration resistant prostate cancer (nmCRPC) who are at high risk of developing metastatic diseaseRed24th March 2021 (n)
DarunavirHIV infection (commissioned by NHS England)Red
Darunavir/cobicistatHIV infection (commissioned by NHS England)Red
Dasabuvir
Hepatitis C (commissioned by NHS England)Red
DasatinibTreatment of cancer (commissioned by NHS England)Red
DaunorubicinTreatment of cancer (commissioned by NHS England)Red
DeferasiroxIron chelation in thalassaemia and sickle cellRed
DeferiproneIron chelation in thalassaemia and sickle cellRed
Defibrotide
Hepatic veno-occlusive disease
Red
DelafloxacinTreatment for acute bacterial skin and skin structure infections (ABSSSI) when standard treatments are not suitable (in line with trust approved guidelines and microbiology advice)RedWY ICS APC November 2022
DelamanidExtensively drug-resistant TB and multi drug-resistant TBRed
DenosumabPrevention of osteoporosisAmber SWYAPC
DenosumabPrevention of skeletal events from breast cancerRed
Dental products on FP10
Black with the exception of those patients on specialist advice following treatment for head and neck cancers (GSI)
See NHSE Guidance on the conditions for which over the counter items should not routinely be prescribed in primary care.
Dequalinium chlorideBacterial vaginosisRed31st July 2019 (n)
Deferasirox (oral)For treating chronic iron overloadRedWY ICS APC November 2022
Desiccated thyroid products (Armous/ERFA). HypothyroidismDo not prescribeWY ICS APC July 2023
DesmopressinFor nocturnal enuresis in children (By any specialist practitioner (within paediatrics (community or hospital) or School Nursing)Specialist RecommendationWY ICS APC April 2022
DeucravacitinibFor treating moderate to severe plaque psoriasis – Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC Sept 2023
Dexamethasone intravitreal implant Macular oedemaRed
Dexamfetamine For attention-deficit hyperactivity disorder (ADHD) in adults only.AmberWY ICS APC July 2023.
Dexamfetamine and lisdexametamineFor attention deficit hyperactivity disorder (ADHD) in school-age children, adolescents .To use only for children only until new guidance is produced. For adults use the new APC guidance.
Amber
Dexcom 1Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementSpecialist RecommendationChair's Action ICS APC May 2023
Dexcom G6Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
Dexcom G7Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
DexmedetomideMaintenance of sedation during intensive careRed
Dexrazoxane
Anthracycline extravasation and cardiotoxicity (NHS England)
Red
Dibotermin alfa Complex spinal surgery
(commissioned by NHS England)
Red
Dicycloverine hydrochlorideTo treat irritable bowel syndrome (IBS) minor diarrhoea and dysmenorrhoea _ for new patients onlyDo not prescribeWY ICS APC November 2022
DidanosineHIV infection (commissioned by NHS England)Red
Dienogest tabletsFor endometriosisSpecialist RecommendationWY ICS APC September 2022
Dihydrotestosterone (Androstanolone®)Unlicensed - recommendation from Leeds paediatric surgeonsRed
DifelikefalinIndicated for the treatment of moderate-to-severe pruritus associated with chronic kidney disease in adult patients on haemodialysis.RedWY ICS APC July 2023
Diltiazem Hydrochloride 2% creamFor the treatment of chronic anal fissures (not licensed for this indication) in adults only. Consider GTN as first line.Green RestrictedWY ICS APC November 2022
Dimethyl fumarateMultiple sclerosis (MS)/psoriasis
(commissioned by NHS England)
Red
Dinoprostone vaginal delivery systemCervical ripening/induction of labourRed
Dinutuximab
Treatment of cancer (commissioned by NHS England)
Red
DinutuximabFor treating severe asthma in adolescents over 12 years and adultsRedWY ICS APC Nov 2023
DiroximelFor treating relapsing-remitting MS NICE TA794RedWY ICS APC November 2022
Disodium pamidronate (IV)Bisphosphonate - all licensed indicationsRed
DisulfiramManagement of patients with drinking problemsDisulfiramMarch 2021 (a)
DOAC (Apixaban, Edoxaban)Apixaban is the most cost effective DOAC and is recommended 1st Line for AF patients suitable for a twice a day DOAC.

Edoxaban is the most cost effective ONCE a day DOAC and is recommended 1st Line for AF patients who require a one daily option where:
- Weight <120kg and BMI <40kg/m2;
CrCl <95mLs/min:
NOTE: edoxaban is not suitable for 12 months post percutaneouos coronary intervention (PCI)
Apixaban is the most cost effective DOAC and is recommended 1st Line for AF patients suitable for a twice a day DOAC.

Edoxaban is the most cost effective ONCE a day DOAC and is recommended 1st Line for AF patients who require a one daily option where:
- Weight <120kg and BMI <40kg/m2;
CrCl <95mLs/min:
NOTE: edoxaban is not suitable for 12 months post percutaneouos coronary intervention (PCI)
NHS England - National procurement for DOACs


WY ICS APC Jan 2024
DOACs (Apixaban, Dabigatran etexilate, Edoxaban, Rivaroxaban)Red for prevention of venous thromboembolic events (VTE) in adults who have undergone elective hip or knee replacement surgery. Red for acute coronary syndrome (ACS). Full courses supplied through Acute Trust. GSI for treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults, subject to local policy. Specialist Initiation Restricted for treatment of left ventricular thrombus (off-label). Green for switching between DOACs for the treatment of acute or recurrent venous thromboembolism (VTE) where patients are established on DOAC therapy for clinical reasons or patient preference. Green for prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation, with one or more risk factors, subject to local policy. Green for the reduction of stroke risk for patients with atrial fibrillation (AF). Edoxaban 1st line for new AF patients where weight <120kg;CrCl<95mLs/min;patient is suitable for any DOAC or any once daily DOAC. Check licensed indications and doses of individual drugsRed for prevention of venous thromboembolic events (VTE) in adults who have undergone elective hip or knee replacement surgery. Red for acute coronary syndrome (ACS). Full courses supplied through Acute Trust. GSI for treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults, subject to local policy. Specialist Initiation Restricted for treatment of left ventribular thrombus (off-label). Green for switching between DOACs for the treatment of acute or recurrent venous thromboembolism (VTE) where patients are established on DOAC therapy for clinical reasons or patient preference. Green for prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation, with one or more risk factors, subject to local policy. Green for the reduction of stroke risk for patients with atrial fibrillation (AF). Edoxaban 1st line for new AF patients where weight <120kg;CrCl<95mLs/min;patient is suitable for any DOAC or any once daily DOAC. Check licensed indications and doses of individual drugsWY ICS APC 24th May 2023
DOACs (Rivaroxaban)For VTE prevention in diabetic limb salvage patients with off-loading casts due to diabetic foot ulcers/Charcot foot. Prevent of venous thromboembolic event (VTE) in adults who have undergone elective hip or knee replacement surgery NICE TA157. Antiplatelet therapy for percutaneous coronary intervention (PCI) for adults with aspirin allergy. For prevention of venous thromboembolism (VTE) in patients who are immobilised with lower leg casts (unlicensed use)RedWY ICS APC 24th May 2023
DOACs (Rivaroxaban)For preventing adverse outcomes after acute management of acute coronary syndrome (ACS)Specialist InitiationWY ICS APC 24th May 2023
DocetaxelAdvanced/metastatic breast cancer, prostate cancerRed
DolutegravirHIV infection (commissioned by NHS England)Red
DomperidoneFor use in breast feeding to increase milk production for short term use. The specialist may not always be a prescriberSpecialist RecommendationWY ICS APC Nov 2023
DonepezilMild to moderate dementia in Alzheimer's diseaseGreen Specialist Initiation
Dornase alfaFor treating Cystic fibrosis in adults and childrenLTHT guidance Specialist Initiation with additional guidanceWY ICS APC Nov 2023 (a)
Dornase alfaFor treating Primary ciliary dyskinesiaDo Not PrescribeWY ICS APC Nov 2023 (a)
DoravirineHIV infection (commissioned by NHS England)Red
DostarimabFor previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency NICE TA779RedICS APC November 2022
DosulepinAll indications Black for new patients for all indications
NHSE items that should not be routinely prescribed in Primary Care
Doxazosin MRAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
Doxylamine (Xonvea®)Nausea and vomiting in pregnancyBack not yet classified
DronedaroneFor the treatment of severe cardiac rhythm disorders as a second line optionDronedaroneWY ICS APC May 2023
DronedaroneFor the treatment of non-permanent Atrial Fibrillation in line with NICE TA197.DronedaroneWY ICS APC Sept 2023
Droperidol injectionPost operative nausea and vomitingRed
DulaglutideType 2 diabetesGreen
Duloxetine Pain - nerveGreen
Dupilumab
Asthma
Red
DupilumabFor treating severe asthma with type 2 inflammation NICE TA751RedICS APC April 2022
DurvalumabCancerRed27th November 2019 (n)
DutasterideFor benign prostatic hyperplasia (BPH) (2nd line to finasteride)Green RestrictedICS APC November 2022
Eculizumab
All indicationsRed
EdoxabanSee DOACsSee DOACs
EdoxabanFor the prevention of venous thrombo-embolism (VTE) in patients with myeloma (ULM)RedWY ICS APC Nov 2023
EfavirenzHIV infection (commissioned by NHS England)Red
Eflornithine cream
For Hirsuitism
Black28th July 2021 (a)
Eladocagene exuparvovecFor treating aromatic L-amino acid decarboxylase deficiency.RedWY ICS APC July 2023
Eliglustat
Gaucher's disease
Red
Elosulfase alfaMucopolysacchardosis IV type ARed
EltrombopagImmune (idiopathic) thrombocytopenic purpuraRed
ElvitegravirHIV infection (commissioned by NHS England)Red
Emicizumab
As per BCSH guidelines for specialised indications
Red
EmpagliflozinFor treating Type 2 diabetes NICE TA336 & 390Green 27th November 2019 (n)
EmpagliflozinFor treating chronic heart failure with reduced ejection fraction NICE TA773Specialist RecommendationICS APC September 2022
EmpagliflozinFor treating chronic heart failure with preserved or mildly reduced ejection fraction NICE TA929Specialist RecommendationWY ICS APC Nov 2023
EmtricitabineHIV infection (commissioned by NHS England)Red
Emtricitine/rilpivirine/tenofovir alafenamideHIV infection (commissioned by NHS England)Red
Emtricitine/rilpivirine/tenofovir alafenamide HIV infection (commissioned by NHS England)Red
Emtricitine/tenofovir/darunavir/cobicistat HIV infection (commissioned by NHS England)Red
Emtricitine/tenofovir/elvitegravir/cobicistat
HIV infection (commissioned by NHS England)Red
EncorafenibTreatment of cancersRed4th Sept 2020
Enfuvirtide HIV infection (commissioned by NHS England)Red
Enstilar® (calcipotriol and betamethasone) PsoriasisGreen if failed on individual components
EntecavirChronic Hepatitis B infectionRed
Enzalutamide
For treating hormone-sensitive metastatic prostate cancer NICE TA712
RedICS APC April 2022
Epoetin (all variants)All indicationsRed22nd January 2020 from Amber
EpoprostenolOff-label indications.RedWY ICS APC 24th May 2023
EptinezumabFor prophylaxis of migraine in adults as per NICE TA871.RedWY ICS APC 24th May 2023
Eptotermin alfaComplex spinal surgery
(commissioned by NHS England)
Red
ErdoseineFor treating Chronic Obstructive Pulmonary disease (COPD)Do Not PrescribeWY ICS APC Nov 2023
ErenumabFor prophylaxis of migraine in adults who have at least 4 migraine days per monthRed22nd September 2021 (a) was Black since16.10.19
EribulinTreatment of cancersRed
ErlotinibTreatment of cancersRed
ErtapenemFor antimocrobial useRedWY ICS APC July 2023
ErtugliflozinType 2 diabetesGreen31st July 2019 (n)
Esketamine Nasal spray For major depressive disorders
Do not PrescribeWY ICS APC Jan 2024
EslicarbazepineEpilepsyGreen Specialist Initiation
Esomeprazol injectionFor use in short bowel/intestinal failure patients who are to be discharged on an intravenous proton pump inhibitorRedICS APC 20th October 2021 (n)
Estradiol transdermal sprayHRT for oestrogen deficiency symptoms in postmenopausal womenGreenWY ICS APC 22nd June 2022
EtanerceptAll indicationsRed
Etelcalcetide

Hyperparathyroidism -dialysis patients only
Red
EthambutolTreatment of TBRed
EtravirineHIV infection (commissioned by NHS England)Red
Etrolizumab
Paediatric indications (where adult NICE TA available)
Red
Everolimus (Afinitor®)
Treatment of cancers
Red
Everolimus (Votubia®)
Tubular sclerosis
Red
Evicel®Tissue adhesive - for use in patients undergoing pelvic surgery or laparoscopic partial nephrectomiesRed
EvolocumabHomozygous familial hypercholesterolaemiaRed
ExemestaneBreast CancerGreen Specialist Initiation
Exenatide Type 2 diabetes (T2DM)Green
Exenatide weekly Type 2 diabetes (T2DM) Green
Ex-vivo expanded autologous human corneal epithelial cells containing stem cells
Limbal stem cell deficiency
Red
Factor IX
As per BCSH guidelines for specialised indications
Red
Factor VII
As per BCSH guidelines for specialised indications
Red
Factor VIIa (Recombinant)
(NovoSeven®)
Bleeding episodes in surgery in specific patientsRed
Factor VIIa
As per BCSH guidelines for specialised indications
Red
Factor VIII
As per BCSH guidelines for specialised indications
Red
Factor VIII inhibitor bypassing factorAs per BCSH guidelines for specialised indications
Red
Factor X

Hereditary factor X deficiency
Red
Factor XIII
As per BCSH guidelines for specialised indications
Red
Faricimab solution for injectionFor treating diabetic macular oedema & wet age-related macular degenerationRedICS APC September 2022
FavipiravirFor chronic norovirus in adults with primary immunodeficiencyRedICS APC September 2022
Febuxostat For patient's intolerant of allopurinol or allopurinol contradicted in line with NICE TA164Green RestrictedICS APC September 2022
FedratinibMyelofibrosisRed4th Sept 2020
FedratinibFor treating disease-related splenomegaly or symptoms of primary myelofibrosis, post-polycythaemia vera myelofibrosis or post-essential thrombocythemia myelofibrosis in adults NICETA756RedICS APC April 2022
Female stress incontinence devicesFor urinary incontinence in women according to NICE NG123Specialist RecommendationICS APC November 2022
FenfluramineDravet DiseaseRed4th Sept 2020
Fentanyl nasal sprayPain relief - use should be restricted to palliative care consultantsGreen Specialist Initiation
Fentanyl IR For non palliative care indications Black
NHSE items that should not be routinely prescribed in Primary Care
Ferric carboxymaltoseIron-deficiency anaemiaRed
Ferric carboxymaltoseHeart failure patients with or without decreased haemoglobin levelsRedWY ICS APC 24th May 2023
Fesoterodine Overactive bladder syndrome Green
Fexofenadine oralChronic spontaneous urticarial and angioedema (For 12 yrs and over)Green29th July 2020 (n)
Fexofenadine oralChronic spontaneous urticarial and angioedema (For 11years and younger)Green Specialist Initiation29th July 2020 (n)
FezolinetantFor treating hot flushes associated with the menopause.Do not Prescribe/Not yet ClassifiedWY ICS APC Jan 2024
Fiasp® (insulin aspart)Treatment of diabetes in adult patients with Type 1 diabetes who are likely to benefit directly from a more rapid onset of action, including:
1.Pregnancy
2.Use of insulin pump
3.Young adults unable to manage with Novorapid because of poor post-prandial glucose control, despite adequate therapeutic trial
Green Specialist Initiation
Fibrinogen
As per BCSH guidelines for specialised indications
Red
FidaxomicinTreatment of Clostridium difficile infection only when it prevents admission to hospital or severe illnessGreen Specialist Initiation
FilgotinibFor the treatment of moderate and severe RARed22nd September 2021 (n)
Filgotinib
Paediatric indications (where adult NICE TA available)
Red
FilgrastimNeutropenia and Barth syndrome
Red
FinasterideFor the treatment of male pattern baldnessDo not prescribeICS APC November 2022
FinasterideFor benign prostatic hyperplasiaGreenICS APC November 2022
FinerenoneFor treating stage 3 and 4 chronic kidney disease with albuminuria in type 2 disbetes in adults.Specialist Initiation with additional guidanceWY ICS APC January 2024
FingolimodManagement of multiple sclerosisRed
Flash glucose monitoring systemsType 1 diabetes mellitus for patients who fulfil the criteriaGreen Specialist Initiation
Flebogamma®All indicationsRed
Flebogammadif®All indicationsRed
Flecainide InjectionFor treatment of arrhythmias (ventricular and supraventricular) unlicensed – Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC Sept 2023
Flecainide OralFor treatment of tachyarrhythmiasSpecialist InitiationWY ICS APC Sept 2023
FludarabineTreatment of cancersRed
FludrocortisoneLeeds Guidelines Orthostatic (Postural) HypotensionGreen RestrictedICS APC November 2022
Flunarizine capsulesFor alternating hemiplegia of childhoodRedICS APC Chair's action January 2022.
Fluocinolone acetonide intravitreal implant Treatment of chronic diabetic macular oedemaRed
Fluorouracil/salicylic acid (Actikerall®) Management of actinic keratosis Green
Flupentixol depot injectionDepressionSpecialist InitiationWY ICS APC Jan 2024
Fluphenazine depot injectionDepot antipsychotic for schizophrenia (to be discontinued at the end of 2018 - no new patients should be started on this if treatment is expected to continue beyond 2018) Green Specialist Initiation
Fluticasone propionate/azelastine hydrochloride nasal sprayRelief of symptoms of moderate to severe seasonal and perennial allergic rhinitisGreen May 2021 (a)
Follitropin alfa/betaIVF - GonadotrophinRed
FondaparinuxParenteral anticoagulantRed
Fosaprepitant injectionChemotherapy induced nausea and vomitingRed
Foscarbidopa & foslevodopaFor treating advanced Parkinson's with motor symptoms RedWY ICS APC Jan 2024
Foscarnet
Cytomegalovirus
Red
Fosfomycin IV2nd line antibiotic for patients with carbapenemase resistant infections or with confirmed anaphylactoid reaction to penicillins presenting with suspected meningitisRed
Fosfomycin (Oral)Antibiotic to be prescribed as per antimicrobial guidelines for the treatment of UTI.GreenWY ICS APC March 2023
Fosfomycin OralFor treating cystic fibrosis in adults and children over 12.GreenWY ICS APC Nov 2023
Fosfomycin injectionFor treating cystic fibrosis in adults and children over 12. Oral fosfomycin is GreenRedWY ICS APC Nov 2023
FostamatinibFor refractory chronic immune thrombocytopenia as per NICE TA835. Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC March 2023 (n)
FremanezumabMigraineRed16.10.19 changed from Black to Red 29th July 2020 (a)
Freestyle Libre 2Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementSpecialist RecommendationChair's Action ICS APC May 2023
Freestyle Libre 3Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
FulvestrantBreast cancerRed
FulvestrantFor the treatment of estrogen receptor positive, locally advanced, or metastatic breast cancer in postmenopausal women. To be used as monotherapy.RedICS APC November 2022
Gabapentin 6% Topical gelFor vulvodyniaRedICS APC Chair's action January 2022.
GalantamineMild to moderate dementia in Alzheimer's diseaseGreen Specialist Initiation
GalcanezumabTreatment for migraine prophylaxisRedICS APC 20th October (a) from SWYAPC was Black 16.10.19
Galsulfase
Mucopolysaccharidosis
Red
GammaCore ®Red for Cluster Headaches
Black for all other indications
Red18th March 2020 (n)
Gammagard®All indicationsRed
Gammanorm®All indicationsRed
Gammaplex®All indicationsRed
Gamunex®All indicationsRed
GanciclovirCytomegalovirus (CMV) Red
GanirelixFor the prevention of premature luteinising hormone (LH) surges in women undergoing controlled ovarian hyperstimulation (COH) for assisted reproduction techniques (ART). Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist adviceRedWY ICS APC March 2023 (n)
GefitinibTreatment of cancers (commissioned by NHS England)Red
GemcitabineTreatment of cancer (commissioned by NHS England)Red31st July 2019 (n)
Gemcitabine injectionFor nasopharyngeal cancerRedICS APC March 2022 (n)
Gemtuzumab ozogamicinTreatment of cancers (commissioned by NHS England)Red
Gender dysphoria or reassignment drugsGuidance available from Leeds Health Pathways (search 'gender')See Information from Leeds Health Pathway
GlatiramerMultiple sclerosis (MS)Red
Glecaprevir/pibrentasvirIndicated for the treatment of chronic hepatitis C virus (HCV) infection in children 3 years and older - NICE TA499RedICS APC September 2022
GlofitamabFor treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsRedWY ICS APC Jan 2024
GlucosamineAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
Glucarpidase
Methotrexate-induced renal dysfunction
Red
Glucagon injection (GlucaGen Hypokit)Available for use in primary care. Secondary care to supply if appropriate according to MSN.
Indicated for the treatment of severe hypoglycaemia in adults, adolescents and children aged 2 and over with diabetes mellitus. To be reviewed in April 2024.
Green RestrictedWY ICS APC Jan 2024
Glucagon injection (Ogluo) - for existing patients
Available in secondary care if required to conserve supplies of GlucaGen Hypokit in line with MSN shortage advice.
Indicated for the treatment of severe hypoglycaemia in adults, adolescents and children aged 2 and over with diabetes mellitus.
RedWY ICS APC Jan 2024
Glucagon injection(Ogluo) - for new patientsDo not prescribe in Primary Care, sufficient supplies of GlucaGen Hypokit are available. Indicated for the treatment of severe hypoglycaemia in adults, adolescents and children aged 2 and over with diabetes mellitus.Do not PrescribeWY ICS APC Jan 2024
GlucaMen DayCGM DeviceDo not PrescribeChair's Action WY ICS APC August 2023
GlucoRx AidexAll indicationsDo not PrescribeChair's Action ICS APC May 2023
Glycerol phenylbutyrate
Urea cycle disorders
Red
Glycopyrronium Bromide (oral)Hypersalivation (adults and children)
LTHT guidance for information
Green Specialist Initiation
May 2021 (a)
Glycopyrronium (topical)HyperhidrosisRed
GnRH analogues (Leuprorelin or Triptorelin) Endometriosis or uterine fibroidsAmber
GnRH analogues (Goserelin, Leuproelin, Triptorelin, Degarelix) Management of prostate cancer Amber
GolimumabAll indicationsRed
GonadorelinIVF - hypothalmic hormoneRed
Gonasi brand only (Chorionic Gonadotrophin)As a sourced alternative as Pregnyl brand hCG has been discontinued for hypogonadotropic hypogonadism in menRedICS APC September 2022
GoserelinManagement of prostate cancer Amber - see GnRH analogues
GoserelinIVF - gonadorelin analogueRed
GoserelinEndometriosisAmber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
GoserelinFor breast cancerGreen Specialist Initiation
Grazoprevir and Elbasvir
Hepatitis C (commissioned by NHS England)
Red
Grazax®
Seasonal allergic hayfeverRed
GuanfacineAttention deficit hyperactivity disorder (ADHD) in school age children, adolescents and adultsAmberCurrently under RMOC consultation and will update accordingly - July 2021
GuselkumabFor moderate to severe plaque psoriasis in adults according to NICE TA521Red
Haloperidol depot injectionDepot antipsychotic for schizophreniaGreen Specialist Initiation
Haemorrhoid preparations available over-the-counterTreatment of haemorrhoidsBlack28th July 2021 (a)
Herbal All indications Black
NHSE items that should not be routinely prescribed in Primary Care
Hepatitis B vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
Hizentra®All indicationsRed
Homeopathic medicinesAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
Human (haem) arginate
Hepatic porphyria
Red
Human Coagulation Factor XFactor X DeficiencyRed4th Sept 2020
Human fibrinogenTreatment of bleeding in patients with congenital hypo, or afibrinogenemia with bleeding tendencyRedICS APC November 2022
Human menopausal
gonadotrophins
IVF - GonadotrophinRed
Human PapillomavirusPrevention of premalignant genital and anal lesions, cervical and anal cancers and genitalGreenICS APC April 2022
Hyaluronic acid derivatives (injectables)Osteoarthritis and other joint conditionsBlack
Hyaluronic acid injectionSpecialist use on local trust formularies onlyRedICS APC November 2022
Hydrocortisone m/r capsules (Efmody)For the treatment of congenital adrenal hyperplasiaSpecialist InititationWY ICS APC 24th May 2023
Hydrocortisone m/r tabletsAdult and paediatric adrenal insufficiencyDo not precribeWY ICS APC 24th May 2023
Hydrocortisone standard release tabletsFor the treatment of paeidatric adrenal insufficiencySpecialist InitiationWY ICS APC 24th May 2023
Hydrocortisone standard release tabletsFor adrenal insufficiency in adultsSpecialist RecommendationWY ICS APC 24th May 2023
Hydrocortisone rectal foamFor treatment of ulcerative colitisSpecialist RecommendationICS APC November 2022
Hydroquinone/tretinoin/hydrocortisone cream (Pigmanorm)Hyperpigmentation (ULM). Also classified as Do Not Prescribe for melasmaRedWY ICS APC July 2023.
Hydroquinone/tretinoin/hydrocortisone cream (Pigmanorm)Do not prescribe for Melasma. Also classified as Red for hyperpigmentation (ULM)Do not prescribeWY ICS APC July 2023.
HydroxycarbamideTreatment of solid tumoursRed
HydroxycarbamideTreatment of Polycythaemia, Thrombocythaemia, Chronic Myeloid Leukaemia (CML) and Psoriasis
Amber
LTHT guidance for information
May 2021 (a)
HydroxycarbamideTreatment of Psoriasis in adultsAmber
LTHT guidance for information
May 2021 (a)
Hydroxychloroquine Interstitial Pneumonitis in children Green Specialist Initiation
see LTHT guidance for information
Hydroxychloroquine Paediatric RheumatologyGreen Specialist Initiation
See LTHT guidance for information
HydroxychloroquineRheumatoid arthritis, systemic and discoid lupus erythematosus (and related connective tissue diseases – off-label)WY ICS APC guidanceUpdated at ICS APC April 2022. Currently under
RMOC consultation and will update accordingly
Hyqvia®All indicationsRed
Ibandronic acid tablets 50mgPost-menopausal women with breast cancerGreen Specialist Initiation
Ibandronic acid injectionBisphosphonate - all licensed indicationsRed
IbrutinibTreatment of cancersRed
Icatibant
For Bradykinin-medicated AngioedemaRedWY ICS APC July 2023.
Icosapent ethylIndicated to reduce the risk of cardiovascular events in adult statin-treated patients at high cardiovascular risk with elevated triglycerideGreen RestrictedICS APC November 2022
IdarubicinTreatment of cancersRed
IdelalisibTreatment of cancersRed
Idursulfase
Mucopolysaccharidosis
Red
Iloprost
Pulmonary arterial hypertension
Red
Imatinib mesilateAll indicationsRed
ImigluceraseEnzyme replacement - Gaucher's diseaseRed
Imipenem/cilastatin/relebactam powderFor Gram-negative bacterial infectionsRedICS APC Chair's action January 2022.
ImipramineFor nocturnal enuresis in childrenSpecialist InitiationICS APC April 2022
ImiquimodAnogenital warts and basal cell carcinoma
Green Specialist Initiation
ImlifidaseTransplant rejection prevention in HLA-sensitised patientsRed4th Sept 2020
Immunoglobulin - Intravenous (IVIg)All indicationsRed
Inclisiran An option for primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet in adults in line with NICEGreen Restricted27th September 2021 (Chair’s action, n)
IndinavirHIV infection (commissioned by NHS England)Red
Indocyanine dyeOphthalmologyRed
InfliximabAll indicationsRed
Inotersen
Amyloidosis
Red
Inotuzumab ozogamicinTreatment of cancers (commissioned by NHS England)Red
Insulin degludecDiabetes mellitus (DM)Green Specialist Initiation
Insulin glargine (Abasaglar®) Diabetes mellitus (DM)Green
Insulin glargine (Toujeo®)Diabetes mellitus (DM)Green
Insulin - Humulin R® - U500500 unit/mL insulin for use in severely insulin resistant patientsRed
Insulin lispro (Lyumjev®)Treatment of diabetes mellitus in adultsGreen Specialist InitiationMay 2021(n)
Interferon gamma-1b injectionFor non-tuberculosis mycobacterial infection (Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned - see specialist advice)RedICS APC November 2022
Intratect®All indicationsRed
Intravenous (IV) normal human immunoglobulins
All indications
Red
Ipilimumab 1mg/kg injection
For previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency. NICE TA716RedICS APC March 2022 (n)
Ipilimumab solutionFor malignant pleural mesotheliomaRedICS APC Chair's action January 2022.
IQoroFor hiatus herniaDo not prescribe/not yet classifiedICS APC November 2022
IrinotecanMetastatic colorectal cancer used with 5-FU and folinic acidRed
Iron sucroseIron deficiency anaemia requiring intravenous therapyRed
Isavuconazole
Fungal infection (licensed indications)
Red
IsoniazidTreatment of TBRed
IsotretinoinOral retinoid - acneRed
Itulazax 12For moderate to severe allergicrhinitis and/or conjunctivitis induced by pollen from the birch homologous groupRedWY ICS APC 22nd June 2022
IvabradineFor children with dilated cardiomyopathy and chronic heart failure (NYHA II to IV) with systolic dysfunction in sinus rhythm with elevated heart rateSpecialist InitiationICS APC September 2022
Ivabradine tabletsFor the management of POTS (Postural tachycardia syndrome) and sinus tachycardia in patients with Long COVIDSpecialist RecommendationWY ICS APC 22nd June 2022
Ivabradine tabletsFor heart failure in line with NICE TA267Specialist RecommendationWY ICS APC 22nd June 2022
Ivabradine tabletsFor angina in line with NICE CG126Green RestrictedWY ICS APC 22nd June 2022
IvacaftorFor the use in the management of cystic fibrosisRedICS APC November 2022
Ivacaftor/Elexacaftor/teacaftor (Symkevi®) Cystic fibrosis (CF) patientsRedICS APC November 2022
Ivermectin cream RosaceaGreen
Ivermectin (Tablets)For the treatment of crusted scabies and topical treatment resistant scabies – Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC Sept 2023
IVF TreatmentAll drugsRed
Ixazomib
All indicationsRed
IxekizumabPsoriatic arthritis in adult patientsRed31st July 2019 (n)
Ixekizumab solutionFor axial spondyloarthritis (licensed)RedICS APC Chair's action January 2022.
Japanese encephalitis For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
KetamineAll indicationsRed
Ketogenic dietary productsFor paediatric patients with epilepsy on a ketogenic diet and under the care of the regional service.
See link to LTHT for additional information on ketogenic prescribable products
Green Specialist Initiation
KetotifenFor all types of chronic allergic conjunctivitis requiring maintenance therapy.GreenICS APC September 2022
Kiovig®All indicationsRed
LacosamideResistant partial seizuresGreen Specialist Initiation
LamivudineHepatitis B (commissioned by NHS England)Red
LamivudineHIV infection (commissioned by NHS England)Red
Lamivudine/abacavir/dolutegravirHIV infection (commissioned by NHS England)Red
Lamivudine/zidovudineHIV infection (commissioned by NHS England)Red
Lamivudine/zidovudine/abacavir HIV infection (commissioned by NHS England)Red
Lanadelumab
Hereditary angioedema
Red
LanreotideNeuroendocrine tumours, acromegalyAmber - SCG not available for this indication. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
LanreotideRed for NHS England indicationsRed
LanthanumControl of hyperphosphataemia in patients with chronic renal failureAmber
LapatinibCancerRed
Laronidase
Mucopolysaccharidosis
Red
LarotrectinibFor treating NTRK fusion-positive solid tumours NICE TA630RedICS APC November 2022
Latanaprost/netarsudil eye dropsFor the reduction of elevated intraocular pressure (IOP) in adult patients with prmary open-angle glaucoma or ocular hypertension for whom monotherapy with a prostaglandin or netarsudil provided insufficient IOP reductionDo not Prescribe/not yet classifiedWY ICS APC Jan 2024
Ledipasvir/sofosbuvir
Hepatitis C (commissioned by NHS England)Red
LeflunomideRheumatoid arthritis and psoriatic arthritis*Please note: awaiting regional update of guidelines* AmberCurrently under RMOC consultation and will update accordingly - May 2021
LenalidomideAll oncolocy indicationsRedWY ICS APC Jan 2024
LenograstimRecombinant human granulocyte - colony stimulating factor - neutropenia and Barth syndromeRed
Lenvatinib (Kisplyx®)For advanced renal cell carcinoma as per NICE TA858. Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice. This is for this specific brand of Lenvatinib. Please note there is another brand classified for different indicationsRedWY ICS APC March 2023 (n)
Lenvatinib (Lenvima®)For differentiated thyroid carcinoma or hepatocellular carcinoma as per NICE TA858. Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice. This is for this specific brand of Lenvatinib. Please note there is another brand classified for different indications.RedWY ICS APC March 2023 (n)
Letermovir
Cytomegalovirus
Red
LetrozoleAdvanced breast cancer - long term therapyGreen Specialist Initiation
LeuprorelinEndometriosis or uterine fibroidsAmber - see GnRH analogues
LeuprorelinManagement of prostate cancer Amber - see GnRH analogues
LevamisoleFor paediatric nephrotic syndromeAmber
LHTH
LevamisoleFor hookworm and roundwormRed31.7.19 (n)
Levetiracetam injectionFor palliative careGreen Specialist Initiation
Levofloxacin (inhaled)
Cystic fibrosis (CF)
Red
LevonorgestrelContraception and treatment of heavy menstrual bleedingGreenICS APC September 2022
Lidocaine plasters for adultsPost herpetic neuralgia in adultsBlack
Lidocaine plasters for 0-18 paediatricsWY Lidocaine plasters for Paediatric 0-18 yearsSpecialist InitiationChair's action ICS APC June 2021
Lidocaine Oxide topical treatmentHaemmorrhoidsDo Not PrescribeICS APC November 2022
Lift®Treatment of hypoglycaemiaBlack - not yet classified27th November 2019 (n)
LinezolidAntibiotic - Microbiologist initiation onlyRed
LinaclotideIrritable Bowel Syndrome (IBS)NICE CG61Specialist RecommendationICS APC April 2022
Liothyronine and
liothyronine with levothyroxine
Hypothyroidism Amber
WYH Commissioning Statement

Liothyronine and
liothyronine with levothyroxine
Thyroid cancerRed
Liothyronine and
liothyronine with levothyroxine
For all other indicationsBlack
Lipegfilgrastim
Neutropenia
Red
Liposomal cytarabine-daunorubicin
Treatment of cancer (commissioned by NHS England)
Red
LiraglutideManagement of obesity Red
Liraglutide Type 2 diabetes (T2DM)Green
LisdexamfetamineFor attention-deficit hyperactivity disorder (ADHD) in adults only.AmberWY ICS APC July 2023
LithiumTreatment and prophylaxis of mania, bipolar disorder and recurrent depressionAmberWY ICS APC March 2023
Lithium carbonateMotor neurone disease (MND)Red
Lixisenatide Type 2 diabetes (T2DM)Green
LomustineTreatment of cancersRed
Lomitapide

Homozygous familial hypercholesterolemia
Red
Lopinavir/ritonavirHIV infection (commissioned by NHS England)Red
LorlatinibAnaplastic lymphoma kinase (ALK)Red29th July 2020 (n)
Loteprednol Peri-operative useRed
Loteprednol GlaucomaGreen Specialist Initiation
Low-molecular Weight heparin (Enoxaparin, Dalteparin and Tinzaparin)
Urgent bridging of patients on warfarin (for VTE or heart valve), with significantly sub-therapeutic INR, in accordance with provider dosing guidance (taking account of patient weight and renal function). Specialist RecommendationWY ICS APC 24th May 2023
Low-molecular Weight heparin (Enoxaparin, Dalteparin and Tinzaparin)
For pre-procedural bridging therapy for patients usually on warfarin (as directed by surgeon/clinical haematologist).Specialist RecommendationWY ICS APC 24th May 2023
Low-molecular Weight heparin (Enoxaparin, Dalteparin and Tinzaparin)Treatment of acute VTE and maintenance during pregnancy.

Specialist InitiationWY ICS APC 24th May 2023
Low-molecular Weight heparin (Enoxaparin, Dalteparin and Tinzaparin)For prophylaxis in obstetric patients.Specialist InitiationWY ICS APC 24th May 2023
Low-molecular Weight heparin (Dalteparin, Enoxaparn and Tinzaparin)Extended post-operative thromboprophylaxis.

RedWY ICS APC 24th May 2023
Low-molecular Weight heparin (Dalteparin, Enoxaparn and Tinzaparin)High risk patients with plaster cast (about 6 weeks whilst immobile) – off-label.RedWY ICS APC 24th May 2023
Low-molecular Weight heparin (Dalteparin, Enoxaparn and Tinzaparin)Postpartum thromboprophylaxis in high risk women (7 days or 6 weeks)RedWY ICS APC 24th May 2023
Low -molecular Weight heparin (Dalteparin, Enoxaparin and Tinzaparin)Treatment of VTE in patients with DVT or PE or other conditions where anticoagulation is required and other treatments are not suitable.
Amber
Low-molecular Weight heparin (Dalteparin, Enoxaparin and Tinzaparin)
Extended treatment & prophylaxis of VTE in adult patients with solid tumoursAmber
Lumacaftor/ivacaftorCystic fibrosis (CF)Red
LumasiranFor treating primary hyperoxaluria type 1.RedWY ICS APC Nov 2023
LurasidoneSchizophrenia (adults)Green Specialist Initiation
LusutromopagFor treating severe thrombocytopenia in adults ith chronicliver disease having planned invasive procedures NICE TA617RedICS APC April 2022
Lutetium (177lu) oxodotreotide
Treatment of cancer (commissioned by NHS England)
Red
Lutein and antioxidants All indications Black
NHSE items that should not be routinely prescribed in Primary Care
MacitentanPulmonary arterial hypertensionRed
Mannitol dry powder inhalerTreatment of cystic fibrosisRed
MavacamtenFor treating symptomatic obstructive hypertrophic cardiomyopathy NICE TA913RedWY ICS APC Nov 2023
MaravirocHIV infection (commissioned by NHS England)Red
MaribavirIndicated for the treatment of cytomegalovirus (CMV) infection after transplant as per NICE TA860. Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC March 2023 (n)
Maviret®Hepatitis C (Commissioned by NHS EnglandRed
Mecasermin Growth failureRed
Medtronic Guardian 4Type 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
Medtronic Smart MDIType 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
Melatonin MR Work is on-going on classification and transfer of care documentAmber.
Shared care guideline
Commissioning statement
How to crush tablets Crushing
11th October 2022 (a)
Melatonin MR Cerebral palsyGreen Specialist Initiation
Commissioning statement
How to crush tablets Crushing
11th October 2022 (a)
Melatonin 1mg/ml oral solutionJet lag in adultsBlack31st July 2019 (n)
MelphalanTreatment of cancersRed
MemantineModerately severe to severe Alzheimers disease.Green Specialist Initiation
Meningitis ACWY vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
MepacrineMalariaRed22nd January 2020
MepacrineTreatment of Systemic Lupus Erythematosus and dermatological conditions in AdultsAmber
LTHT guidance for information
May 2021 (a)
Mepolizumab
AsthmaRed
Mercaptamine hydrochloride viscous eyedropsFor corneal cystine deposits in people aged 2 years and overRedICS APC Chair's action January 2022.
MercaptopurineGastroenterologySWYAPC30th September 2020 (a)
MercaptopurineFor the treatment of Inflammatory Bowel Disease in ChildrenAmber
MercaptopurineTreatment of cancersRed
MeropenemFor use as recommended by local antimicrobial guidance or by microbiology.RedWY ICS APC Jan 2024
Meropenem-varbobsctam IV injectionFor klebsiella pneumoniae carbapenemase producint carbapenem-resistant Enterobacteriacease or when high suspicion of thisRedICS APC April 2022
MesalazineFor the treatment of ulcerative colitis and Crohn's disease and other types of inflammatory bowel disease.Specialist InitiationWY ICS APC Nov 2023
Metaraminol solutionIndicated for the treatment of acute hypotension due to loss of vasoconstrictor tone as may occur during spinal anaethesia and as an adjunct to accepted remedial procedures.Red22nd September 2021 (n)
MethenamineLower UTI Prophylaxis in adult womenGreen RestrictedICS APC November 2022
Methotrexate
(oral, IM & SC)
Cancer indicationsRed
Methotrexate
(IM and SC)
Non-cancer indicationsRed
Methotrexate S/CAlone or with corticosteriods for mild to moderate Crohn's disease in patients refractory to thiopurines.RedICS APC November 2022
Methotrexate (oral)Licensed indications – Rheumatoid arthritis, Psoriatic arthritis
Off-label indication - Other inflammatory arthritides, connective tissue disease (not for cancer or dermatological conditions)
LTHT guidanceCurrently under RMOC consultation and will update accordingly - May 2021
Methotrexate (oral)Licensed indication: severe uncontrolled psoriasis.
Off-label conditions: e.g pemphigoid, pemphigus, sarcoidosis, scleroderma, dermatomyositis, eczema. See shared care guideline for further indications
Amber
Methotrexate (oral)Non cancer indications in paediatrics Amber
Methoxyflurane inhalation vapourAnaestheticRedWY ICS APC July 2023.
Methylnaltrexone subcutaneous injectionSevere opioid induced constipationBlack
MethylphenidateFor ADHD in school-age children, adolescents and adultsAmber
MetolazoneFor treatment of oedema related to kidney disease and heart failure and for mild/moderate hypertension along or in combination with other antihypertensive medicinesSpecialist RecommendationICS APC November 2022
MetyraponeManagement of patients with Cushing’s SyndromeRed for new patients
Green Specialist Initiation for existing patients
MexiletineNon-dystrophic myotonia (commissioned by NHS England)
Red
MexiletineFor treating life-threatening ventricular arrhythmiasRedWY ICS APC Nov 2023
MianserinFor treating depressionSpecialist RecommendationWY ICS APC Jan 2024
Micafungin
Fungal infections
Red
Miconazole buccalOropharyngeal candidiasisGreen Specialist Initiation
Micronised progesterone (Oral)With oestrogen in post-menopausal women with an intact uterus, as HRTGreenWY ICS APC 22nd June 2022
Midazolam oromucosal
solution
Convulsive seizuresGreen Specialist Initiation
MidodrineFor postural hypertension, vasovagal syncope, or severe orthostatic hypotension due to autonomic dysfunction when corrective factors have been ruled out and other treatments are inadequate.Specialist RecommendationWY ICS APC 24th May 2023
MidostaurinTreatment of cancers (commissioned by NHS England)Red
MidostaurinFor untreated acute myeloid leukaemia NICE TA523RedICS APC November 2022
Migalastat
Fabry's disease
Red
Miglustat
Gaucher's disease/Niemann-Pick disease
Red
MiglustatFor treating late-onset Pompe disease (with cipaglucosidase alfa) NICE TA912RedWY ICS APC Nov 2023
Minocycline for acneTreatment of acne for new patientsBlack28th July 2021 (a)
Minocycline for acneTreatment of acne for existing patients (with prescribers considering deprescribing in all patients where appropriateGreen28th July 2021 (n)
Minoxidil (all topical preparations)For the treatment of male and female pattern baldnessDo not prescribeICS APC November 2022
MinoxidilTreating severe hypertension, in additional to a diuretic and a betablockerSpecialist RecommendationICS APC November 2022
Mirabegron Overactive bladder syndrome Green
MirikizumabFor treating moderately to severely active ulcerative colitisRedWY ICS APC Jan 2024
MirtazapineFor treating depressionGreenWY ICS APC Jan 2024
Mitomycin C injectionFor dacryocystorhinostomy (Treatment for a blocked tear duct)RedICS APC April 2022
MitotaneTreatment of cancersRed
MobocertinibFor the treatment of adult patients with epidermal growth factor receptor exon 20 insertion mutation-positive locally advanced or metastatic non-small cell lung cancer who have received prior platinum based chemotherapy as per NICE TA855.RedWY ICS APC March 2023 (n)
MoclobemideFor treating depression and anxietySpecialist InitiationWY ICS APC Jan 2024
ModafinilTreatment of Adults with – Narcolepsy, Fatigue in patients with MS, Residual sleepiness associated with Obstructive Sleep Apnoea and Idiopathic Hyper-somnolenceAmber
LTHT guidance for information
May 2021 (a)
MogamulizumabFor previously treated mycosis fungoides and Sezary Syndrome - NICE TA754RedWY ICS APC 22nd June 2022
MolnupiravirAntiviral medication that inhibits the replication of certain RNA viruses, and is used to treat COVID-19 in those infected by SARS-CoV-2RedICS APC Chair's action January 2022.
MosunetuzumabFor treating relapsed or refractory follicular lymphoma NICE TA892Do Not PrescribeWY ICS APC Nov 2023
Mycophenolate Off-label indications –systemic lupus erythematosus (SLE), particularly lupus nephritis, other connective tissue diseases and systemic vasculitis. Treatment of myasthenia gravis in patients intolerant or non-responding to azathioprine*Please note: awaiting regional update of guidelines* AmberCurrently under RMOC consultation and will update accordingly - May 2021
Mycophenolate Cytotoxic immunosuppressant - prophylaxis of acute transplant rejectionAmber
Mycophenolate Indications not classified as amberRed
Mycophenolate Paediatric rheumatologyAmber Currently under RMOC consultation and will update accordingly - July 2021
MycophenolateFor the prevention of relapse in frequently relapsing nephrotic syndrome in paediatricsAmber Currently under RMOC consultation and will update accordingly - July 2021
MydraneAs drug to dilate pupil and also prevent pupil becoming small during Cataract surgeryRed22nd January 2020
Mysimba® (naltrexone plus bupropion) For the treatment of overweight and obesity Black
NabiloneAntiemetic; Multiple sclerosis treatmentRed
NafarelinIVF - gonadorelin analogueRed
Nalmefene
(only for patients under the care of alcohol services including shared care)
Alcohol dependenceRed
NaloxegolFor opioid-induced constipation according to NICE TA345Green RestrictedICS APC November 2022
Naloxone hydrochloride injectionFor pruritus in liver disease - licensed for opioid overdoseRedICS APC Chair's action January 2022.
NaltrexoneMaintain abstinence in alcohol-dependent patientsNaltrexoneMarch 2021 (a)
NaltrexoneFor pruritus in liver diseaseSpecialist InitiationICS APC April 2022
NaltrexoneHailey-Hailey diseaseRed20th September 2019 (n)
Nasal sprays available over-the-counter for symptomatic relief of hay fever and congestion For the treatment of mild to moderate hay fever/seasonal rhinitisBlack28th July 2021 (a)
Natalizumab
Multiple sclerosis (MS)
Red
Natalizumab SC injectionIn pre-filled syringes for multiple sclerosis NICE TA127RedICS APC April 2022
Natamycin eye dropsTreatment of keratitis due to a mouldRed29th July 2020 (n)
Needles for pre-filled and reusable Insulin pensFor needles costing more than £5 per 100Black
NHSE items that should not be routinely prescribed in Primary Care
NefopamPainBlack for new patients unless initiated and successfully trialled under the care of a pain specialist as per SWYAPC nefopam commissioning statement10th September 2020
Neilmed (purified sea water)Nsal rinse for postnasal surgery and endonasal pituitary surgeryRedWY ICS APC Nov 2023
NelarabineTreatment of cancersRed
NelfinavirHIV infection (commissioned by NHS England)Red
Neomycin oral tablet Surgical prophylaxis alongside oral metronidazole, plus standard intravenous surgical prophylaxis for colorectal surgery – with mechanical bowel preparationRed
Neonatal ProbioticsTo aid reduction in risk of necrotising enterocolitis.RedWY ICS APC July 2023.
Nephro-vite®Vitamin supplementation in renal impairmentGreen Specialist Initiation
NeratinibBreast CancerRed27th November 2019 (n)
Netilmicin/dexamethasone eye dropsIndicated for the treatment of inflammatory ocular conditions of the anterior segment of the eye, including post-operative cases, where bacterial infection or a risk of bacterial infection with netilmicin-susceptible micro organisms existsDo not prescribe/not yet classifiedWY ICS APC 22nd June 2022
Netupitant and palonosetronAnti-emetic for use with cancer chemotherapyRed
NeuropadFor detecting preclinical diabetic peripheral neuropathyDo not prescribeICS APC November 2022
NevirapineHIV infection (commissioned by NHS England)Red
NilaquaWaterless bathing productDo not prescribe/not yet classifiedICS APC November 2022
NilotinibTreatment of cancersRed
Nintedanib
Treatment of cancers; idiopathic pulmonary fibrosis
Red
NintedanibTreatment of other chronic fibrosing interstitial lung diseases (ILDS) with a progressive phenotype (adults) NICE TA747RedICS APC April 2022
Nintedanib (oral)For treating progressive fibrosing interstitial lung diseaseRedWY ICS APC 22nd June 2022
NiraparibTreatment of cancersRed
Nirmatrelvir/RitonavirFor COVID-19 in adults not requiring oxygen who are at increased risk of severe diseaseRedICS APC April 2022
NitazoxanideUnlicensed in UK - for treatment of Cryptosporidiosis and GiardiasisRed
NitisinoneAlkaptonuria; tyrosinaemia
Red
Nitric oxideFor treating pulmonary arterial hypertensionRedWY ICS APC 24th May 2023
NivolumabTreatment of cancers NICE TA780, 746,736,724,716,713,707RedICS APC September 2022
NivolumabFor recurrent or metastatic squamous cell carcinoma of head and neck after platinum-based chemotherapy. For adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancer.RedICS APC April 2022
Nivolumab solutionFor malignant pleural mesotheliomaRedICS APC Chair's action January 2022.
Nivolumab 3mg/kg injectionFor previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency. NICE TA716RedICS APC March 2022 (n)
Nonacog beta pegol
Haemophilia B
Red
Non-nucleoside reverse transcriptase inhibitorsHIV infection (commissioned by NHS England)Red
Norethisterone 5mg tabletsFor the postponement of menstruationGreenWY ICS APC Nov 2023
Normal immunoglobulinAll indicationsRed
Nucleoside reverse transcriptase inhibitors (nucleoside analogues)HIV infection (commissioned by NHS England)Red
Nusinersen intrathecal injection
Spinal muscular atrophy (commissioned by NHS England)
Red
Obeticholic acid
Primary biliary cirrhosis
Red
Obinutuzumab Treatment of cancersRed
Ocrelizumab
Multiple sclerosis (MS)
Red
OcriplasminRetinal disordersRed
Octagam®All indicationsRed
OctreotideFor post operative chylothorax in paediatric cardiothoracic patientsRedWY ICS APC 24th May 2023
OctreotideFor palliative care indicationsGreen Specialist Initiation
OctreotideAmber for licensed CCG funded indications (symptoms associated with carcinoid tumours with features of carcinoid syndrome, VIPomas, glucagonomas, acromegaly, prevention of complications after pancreatic surgery). Red for NHS England indicationsAmber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
Red for NHS England indications
Octreotide (off-label indications)Off-label indicationsRed
Odevixibat sesquihydrateIndicated for the treatment of progressive familial intrahepatic cholestasis (PFIC) in patients aged 6 months or older.RedICS APC September 2022
Ofatumumab injectionFor relapsing multiple sclerosisRedICS APC 20th October 2021 (n)
Olanzapine (IM injection)Atypical antipsychotic - schizophrenia and bipolar disordersRed
Olanzapine (oral)Atypical antipsychotic - schizophrenia and bipolar disordersGreen Specialist Initiation
OlaparibTreatment of cancersRed
OlaparibFor the maintenance treatment of adult patients with advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer.Red22nd September 2021(n)
Olopatadine/mometasone nasal sprayAdults and adolescents 12 years of age and older for the treatment of moderate to severe nasal symptoms associated with allergic rhinitisGreenICS APC Chair's action January 2022.
OmalizumabFor all indicationsRedWY ICS APC Nov 2023 (a)
Ombitasvir/paritaprevir/ritonavir Hepatitis C (commissioned by NHS England)Red
Omega 3 and other fish oilsAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
OpicaponeFor Parkinson's diseaseGreen Specialist Initiation
Oral rehydration solutionShort bowel patientsSpecialist InitiationICS APC November 2022
Oral immunotherapy (Acarizax, Grazax and Itulazax)For the treatment of allergen specific fhinitis and conjunctivitis in adult and paediatric servicesSpecialist Initiation with additional guidanceWY ICS APC Jan 2024
Oraldene® gel and mouthwashOral hygeineRed
OsimertinibTreatment of cancersRed
OsimertinibAdjuvant treatment after complete tumour resection in adults with stage 1b to 3a non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor(EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations NICE TA761RedICS APC April 2022
Ospemifene 60mg tabletFor moderate-severe vulvar and vaginal atrophy in postmenopausal women who are not candidates for vaginal oestrogen therapy or who cannot administer vaginal oestrogen.Green RestrictedWY ICS APC March 2023 (n)
OxaliplatinMetastatic colorectal cancer used with 5-FU and folinic acidRed
OxandroloneTreatment of hypermetabolism in burns patientsRed29th July 2020 (n)
OxcarbazepineEpilepsy Green Specialist Initiation
OxcarbazepineFor the treatment of trigeminal neuralgia and 2nd line after carbamazepineSpecialist InitiationWY ICS APC 24th May 2023
OxybutyninFor nocturnal enuresis in childrenSpecialist RecommendationWY ICS APC Jan 2024
Oxycodone and naloxone MR All indications Black
NHSE items that should not be routinely prescribed in Primary Care
OzanimodRecommended as an option for treating moderately to severely active ulcerative colitis in adults as per NICE TA828RedICS APC November 2022
Ozanimod hydrochloride
Multiple sclerosis (MS)
Do not prescribeICS APC October 2021
PalbociclibCancerRed
Paliperidone depot 6 monthlyFor use as an antipsychotic in the treatment of schizophrenia. Please be aware this medicine classification is dependent on the productRedWY ICS APC March 2023 (a)
PalivizumabProphylaxis of respiratory syncytial virus (RSV) Red
Pancreatin preparationsPancreatic insufficiencySpecialist RecommendationICS APC November 2022
PanitumumabTreatment of cancersRed
PanobinostatTreatment of cancersRed
Para-aminosalicylic acid

TB
Red
Paracetamol and tramadolAll indications Black
NHSE items that should not be routinely prescribed in Primary Care
Parathyroid hormone
Specialist endocrinology conditions
Red
Paravit CF CapsulesCystic FibrosisGreen Specialist Initiation27th November 2019 (n)
Paravit CF CapsulesCholestatic liver diseaseGreen Specialist Initiation27th November 2019 (n)
Paricalcitol
Hyperparathyroidism (commissioned by NHS England)
Red
Paritaprevir
Hepatitis C (commissioned by NHS England)Red
Pasireotide
Cushing's disease
Red
Patiromer For acute management hyperkalaemia as per NICE TA623RedWY ICS APC 24th May 2023
PatiromerLonger term use for hyperkalaemia in dialysis patients, struggling to adhere to dietary restrictions or who remain hyperkalaemic despite dietary restrictions. Note as patients attend dialysis units bloods will be taken and monitored by Secondary Care.
Specialist InitiationWY ICS APC 24th May 2023
Patisiran
Amyloidosis (commissioned by NHS England)
Red
PaxlovidAn antiviral medicine used for treating mild-to-moderate COVIDRedICS APC Chair's action 16th February 2022
Pazopanib
Treatment of cancers
Red
PegaspargaseTreatment of cancersRed
PegcetacloplanFor paroxysmal nocturnal haemoglobinuria NICE TA778RedICS APC September 2022
Pegylated liposomal doxorubicinTreatment of cancersRed
Peg-filgrastim Reduction in neutropenia with cytotoxic chemotherapyRed
Peg-interferon alfaTreatment of hepatitis B and CRed
Peginterferon beta-1aMultiple sclerosis (MS)Red
Pegunigalsidase alfaFor treating Fabry disease NICE TA915RedWY ICS APC Nov 2023
PegvisomantAcromegalyRed
PembrolizumabTreatments of Cancer Red
PembrolizumabFor the first line treatment of squamous non-small cell lung cancer in combination with carboplatin and paclitaxelRedICS APC September 2022
PembrolizumabFor untreated advanced oseophageal and gastro-oesophageal junction cancer. For treating relapsed or refractory classical Hodgkin lymphoma in people added 3 and older NICETA772RedICS APC April 2022
PembrolizumabFor oncology indicationsRedWY ICS APC Jan 2024
Pembrolizumab solution for infusionFor untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyRedICS APC Chair's action January 2022.
PemetrexedTreatment of cancersRed
PemigatinibFor cholangiocarcinoma with FGFR2 fusion or rearrangement NICE TA722RedICS APC April 2022
Pentosan polysulphateInterstitial Cystitis Red January 2020 (removing unlicensed)
PenicillamineFor rheumatoid arthritis – 12-month extension of the SWY guidance approved to be used by Bradford & Craven/Calderdale/Kirklees and Wakefield until a full review can take place.PenicillamineWY ICS APC Sept 2023
PentoxifyllineFor treating venous leg ulceration. Continue treatment until ulcer heals but review on a monthly basisSpecialist Recommendation RestrictedWY ICS APC March 2023 (n)
PentoxifyllineFor intermittent claudication in peripheral arterial disease (Not recommended by NICE TA223)Do not prescribeWY ICS APC 24th May 2023
PerampanelEpilepsyGreen Specialist Initiation
Perindopril arginine All indications Black
NHSE items that should not be routinely prescribed in Primary Care
PertuzumabTreatment of cancersRed
Phenazone/lidocaine hydrochloride ear drops (Otigo)For local symptomatic treatment and relief of pain in the following diseases of the middle ear without tympanic perforation Otitis media (acute) antimicrobial prescribing NICE guidanceGreenWY ICS APC March 2023 (n)
PhenelzineFor depressed patients clinically characterised as 'atypical', 'non endogenous', 'neurotic' or where treatment with other antidepressants has failed in adult services.Specialist Initiation guidanceWY ICS APC July 2023.
Phenol 2% in Zinc paste Intractable pruritus aniRed
PhenylbutazoneNSAID - ankylosing spondylitisRed
Phenylephrine/tropicamide ophthalmic insert (Mydriasert®)Surgical mydriasisRed
Pholcodine containing Medicinal productsFor treating coughs and colds. Discontinued.Do not prescribeWY ICS APC 24th May 2023
Phytomenadione capsulesNot licensed in UKGreen Specialist Initiation
Pimecrolimus (topical)For the treatment of oral lichplanus and similar immune-inflammatory oral mucosal disease (off license)Specialist RecommendationICS APC September 2022
PirenzepineFor clozapine-induced hypersalivationRedWY ICS APC Jan 2024
PirfenidoneAntifibrotic for idiopathic pulmonary fibrosisRed
PitolisantFor treating narcolepsy with or without cataplexy (initiated by a specialist). This drug is also classified at Do Not Prescribe for sleep apnoeaRedWY ICS APC Nov 2023
PitolisantFor treating sleep apnoea. This drug is also classified as red for narcolepsy with or without cataplexy.Do Not PrescribeWY ICS APC Nov 2023
Pivmecillinam Urinary tract infectionsGreen
PixantroneTreatment of cancersRed
Bowel preparation productsIndicated in adults for bowel cleansing prior to procedureRed28th July 2021 (n).
2nd November 2022 changed from Plenvu to bowel preparation products
PlerixaforStem cell mobilisationRed
PolatuzumabTreating relapsed or refractory diffuse large B-cell lymphoma in adults who cannot have a haematopoietic stem cell transplantRed24th March 2021(n)
Pomalidomide
Treatment of cancers. Myelofibrosis
Red
Ponatinib
Treatment of cancersRed
Ponesimod f/c tablets (initiation and maintenance packs)Treatment of adults with relapsing forms of multiple sclerosis with active disease defined by clinical or imaging features NICE TA767RedICS APC March 2022 (n)
Poractant alfa
For treating respiratory distress syndrome.
RedWY ICS APC Nov 2023 (a)
PosaconazoleAll indicationsRed
Potassium Citrate tabletsFor renal and ureteric stones (ULM) in adults and childrenRedICS APC 20th October 2021 (n)
Potassium iodideFor treatment of erythema nodosumRed
PralsetinibFor RET+ve NSCLC - NICE TA812 does not recommend for this indicationDo not prescribeICS APC November 2022
Pramipexole standard release tabletRestless legs syndromeGreen ICS APC November 2022
Pramipexole standard release tabletsFor Parkinson's diseaseSpecialist RecommendationICS APC November 2022
Pramipexole MR tabletsParkinson's diseaseSpecialist RecommendationWY ICS APC 22nd June 2022
Prasterone pessariesFor treating vulvar and vaginal atrophy in line with NICEGreen RestrictedWY ICS APC Jan 2024
PrasugrelCobination with aspirin for the prevention of atherothrombotic events in patients with acute coronory syndrome undergoing percutaneous coronary interventionGreen Specialist Initiation
PrasugrelFor the treatment of patients with intracranial stentsSpecialist InitiationWY ICS APC Nov 2023 (a)
Prednisolone enema/suppositoriesUlcerative colitisSpecialist RecommendationICS APC November 2022
Prednisone MRRheumatoid arthritis (RA)Black
Pre-exposure prophylaxis (PrEP)For prevention of HIV in adults. Only as part of a clinical trial. Further details from NHS England who commission thisBlack
Pretomanid
Multi-drug resitant TB
Red
Privagen®All indicationsRed
ProbioticsAll indicationsBlack Conditions for which over the counter items should not routinely be prescribed
ProcarbazineTreatment of cancersRed
Progesterone (micronised) vaginalFor treatment of threatened miscarriageSpecialist InitiationICS APC September 2022
PropanthelineHypersalivationSpecialist RecommendationICS APC November 2022
PropranololPaediatric Migraine Green Specialist Initiation
See LTHT guidance for information
Protease inhibitorsHIV infection (commissioned by NHS England)Red
Protein C
As per BCSH guidelines for specialised indications
Red
Protein kinase inhibitorsEndocrinology; non-malignant conditionsRed
Prothrombin complexAs per BCSH guidelines for specialised indicationsRed
PrucaloprideFor use with Colon Capsule EndoscopyRedICS APC November 2022
PrucaloprideChronic constipation in women when other laxatives fail to provide an adequate response - NICE TA211Specialist RecommendationICS APC November 2022
PrucaloprideFor use as a prokinetic in paediatric patients with intestinal pseudo obstructionSpecialist InitiationWY ICS APC Jan 2024
PyrazinamideTreatment of TBRed
Pyridoxine (Xonvea®)Nausea and vomiting in pregnancyBlack not yet classified
QuetiapineAtypical antipsychotic - schizophreniaGreen Specialist Initiation
QuinidineShort QT syndrome, Brugada syndrome, and idiopathic ventricular fibrillation (VF)Red WY ICS APC 24th May 2023
Quinidine sulphate tabletsVentricular arrhythmiaRed31st July 2019 (n)
Rabies vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
Radium-223 dichlorideTreatment of cancersRed
RaltegravirHIV infection (commissioned by NHS England)Red
RaltitrexedAdvanced colorectal cancerRed
Ranibizumab All indicationsRed
RanolazineNot for routine use as an antianginal agent. It is used as an add-on for symptomatic treatment of stable angina pectoris inadequately controlled or intolerant to other antianginal therapeutics NICE CG126Specialist Recommendation RestrictedWY ICS APC 24th May 2023
RasagilineParkinson's diseaseGreen Specialist Initiation
Rasburicase
Hyperuricaemia
Red
Ravulizumab
Paroxysmal nocturnal haemoglobinuria (commissioned by NHS England)
Red
Ravulizumab infusionFor treating atypical haemolytic uraemic syndromeRedICS APC Chair's action January 2022.
RegorafenibTreatment of cancersRed
Relugolix/estradiol/norethisterone (Ryeqo)For treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age as per NICE TA832.Specialist RecommendationICS APC November 2022
RemdesivirTreatment for SARS-CoV-2 infectionRed29th July 2020 (n)
Renavit®Vitamin supplementation in renal impairmentGreen Specialist Initiation
Reslizumab
AsthmaRed
RibavirinHepatitis C (commissioned by NHS England)Red
RibociclibCancerRed
Ribociclib tabletsFor breast cancerRedICS APC Chair's action January 2022.
RifabutinFor treating pulmonary tuberculosis – Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist advice.RedWY ICS APC Sept 2023
RifampicinTreatment of TBRed
Rifampicin For pruritus in liver disease - unlicensed for use in children for pruritus.Specialist InitiationLTHT guidanceICS APC April 2022
RifampicinTreatment of Folliculitis Decalvans, Acne Keloidalis & Hidradenitis Suppurativa in AdultsGreen Specialist InitiationMay 2021 (n)
Rifater® (rifampicin/isoniazid/pyrazinamide )
Treatment of TBRed
RifaximinTreatment of small intestinal bacterial overgrowth and for the treatment of chronic refractory pouchitis
Red
RifaximinPrevention of hepatic encephalopathy in adult patientsGreen Specialist Initiation
Rifinah® (rifampicin/isoniazid)Treatment of TBRed
RilpivirineHIV infection (commissioned by NHS England)Red
RiluzoleTo extend life or time to mechanical ventilation for patients with amyotrophic lateral sclerosisAmber
LTHT guidance
March 2020 (a)
Currently under RMOC consultation and will update accordingly - July 2021
Rimegepant (Prevention) Vydura®For preventative treatment of episodic migraine in adults in line with NICE TA906. Patients transferred after a minimum of 12 weeks.Specialist InitiationWY ICS APC Sept 2023
Rimegepant (Treatment) Vydura For acute treatment of migraine with or without auraSpecialist InitiationWY ICS APC Jan 2024 interim classification
Riociguat
Pulmonary arterial hypertension (CTEPH).
Pulmonary arterial hypertension
Red
RipretinibFor treating advanced gastrointestinal stromal tumours after 3 or more therapies NICE TA881Do Not PrescribeWY ICS APC Nov 2023
RisankizumabIndicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.Red22nd September 2021 (n)
RisankizumabManagement of moderate to severe Crohn's disease in people aged >16 years with an inadequate response or intolerance to conventional or biologic therapy (licence extension) ID3986 GID-TA10884)RedICS APC September 2022
RisdiplamSpinal muscular atrophyRed4th Sept 2020
Risperidone injection Schizophrenia and other psychoses in patients tolerant to risperidone by mouthRed
Risperidone oralAtypical antipsychotic - schizophreniaGreen Specialist Initiation
RitonavirHIV infection (commissioned by NHS England)Red
Ritonavir/lopinavirHIV infection (commissioned by NHS England)Red
RituximabAll usesRed
Rivaroxaban See DOACsSee DOACs
RivaroxabanFor preventing atherothrombotic events in people with coronary or peripheral artery disease when taken in combination with aspirin as per NICE TA607Green RestrictedICS APC November 2022
RivaroxabanFor the prevention of venous thrombo-embolism (VTE) in patients with myeloma (ULM)RedWY ICS APC Nov 2023
RivastigmineMild to moderate dementia in Alzheimer's diseaseGreen Specialist Initiation
Rivastigmine patchesMild to moderate dementai in patients with swallowing difficultiesGreen Specialist Initiation
RoflumilastAs per TA461: Roflumilast, as an add-on to bronchodilator therapy, is recommended as an option for treating severe chronic obstructive pulmonary disease in adults with chronic bronchitis, only if:
•the disease is severe, defined as a forced expiratory volume in 1 second (FEV1) after a bronchodilator of less than 50% of predicted normal, and
•the person has had 2 or more exacerbations in the previous 12 months despite triple inhaled therapy with a long-acting muscarinic antagonist, a long-acting beta-2 agonist and an inhaled corticosteroid
Green Specialist Initiation
RomiplostimImmune (idiopathic) thrombocytopenia Red
RomosozumabTreating of severe osteoporosis - NICE TA791RedChair's Action 25th August 2022
RopiniroleFor Parkinson’s disease. Please note this medicine is also classified for the treatment of restless leg syndrome (see separate entry Green Restricted).Specialist RecommendationWY ICS APC March 2023 (a)
RopiniroleFor treatment of restless legs syndrome. Restricted in line with the CKS guidance for restless leg syndrome. Please note this medicine is also classified for the treatment of Parkinson’s disease (see separate entry Specialist Recommendation)Green RestrictedWY ICS APC March 2023 (n)
Rotigotine transdermal
patches
Parkinson's disease, either used alone or as an adjunct to levodopa with dopa-decarboxylase inhibitor Green Specialist Initiation
RoxadustatIndicated for treatment of adult patients with symptomatic anaemia associated with chronic kidney disease NICE TA807RedWY ICS APC November 2022
Rubefacients (excluding topical NSAIDs)All indications Black
NHSE items that should not be routinely prescribed in Primary Care
RucaparibTreatment of cancersRed18th March 2020 (n)
RufinimideEpilepsyGreen Specialist Inititation
Rupatadine fumarateFor treating chronic urticaria/angioedemaSecialist Initiation with additional guidance
LTHT guidance
RuxolitinibTreatment of cancersRed
Sacubitril valsartanAccording to NICE TA388 for treating symptomatic chronic heart failure with reduced ejection fractionGreen Specialist Initiation
Sacituzumab govitecan 180mg solution for infusionLicensed for the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancerRedWY ICS APC March 2022 (n)
SafinamideParkinson's disease, as an adjunct to levodopa alone or in combination with other antiparkinsonian drugs, for mid- to late-stage fluctuationsGreen Specialist Initiation
SapropterinFor children with phenylketonuria. Maternal phenylketonuria (NHS England)
Red
SaquinavirHIV infection (commissioned by NHS England)Red
SarilumabPaediatric indications (where adult NICE TAs are available)Red
SarilumabFor moderate to severe active rheumatoid arthritis in adults according to NICE TA485Red
Sativex® Spray (cannabis-based product. Treatment of spasticity in patients with MSBlack not yet classified. For further information see West Yorkshire Health and Care Partnership WY Partnershipwebsite28th July 2021 (a)
Saxagliptin Type 2 diabetes (T2DM)Green
Sebelipase alfaLysosomal acid lipase deficiencyRed
SecukinumabLicensed for the treatment of active non-radiographic axial spondylarthritis with objective signs of inflammation. NICE TA719RedWY ICS APC March 2022 (n)
SecukinumabFor severe plaque psoriasis in children and young people NICE TA734RedWY ICS APC April 2022
SecukinumabFor all indicationsRedWY ICS APC Jan 2024
SelexipagPulmonary arterial hypertensionRed
Selpercatinib hard capsules (40mg & 80mg)Treatment of adults with advanced RET fusion-positive non-small cell lung cancer NICE TA760
Treatment of adults and adolescents aged ≥12 years with advanced RET-mutant medullary thyroid cancer NICE TA742
RedWY ICS APC March 2022 (n)
SelpercatinibFor treating advanced thyroid cancer with RET alterations. For previously treated RET fusion-positive advanced non-small-cell lung cancer NICE TA742RedWY ICS APC April 2022
SelumetinibFor the treatment of symptomatic inoperable plexiform neurofibromas (PN) in paediatric patients with neurofibromatosis type 1 aged 3 years and above in line with HST20.RedWY ICS APC November 2022
Semaglutide (Wegovy)WY Partnership For managing overweight and obesity as per NICE TA875. This is an interim holding position awaiting further discussions on how NICE TA875 will be implemented across West Yorkshire.Do not prescribe/not yet classified. WY ICS APC March 2023 (a)
Semaglutide OralTreatment of adults with insufficiently controlled T2DM, according to NICE guidelines (NG28)Green24th March 2021 (n)
SertralineFor pruritus in liver diseaseSpecialist RecommendationWY ICS APC April 2022
SevelamerHyperphosphataemia in chronic kidney disease patients who may also be on haemodialysis or peritoneal dialysisAmber
SildenafilPost prostatectomy or radiotherapyGreen Specialist Initiation
SildenafilRaynaud's phenomenon and digital ulceration associated with connective tissue diseaseGreen Specialist InitiationMay 2021 (a)
SildenafilFor treating pulmonary hypertension in adults and paediatricsRedWY ICS APC 24th May 2023
Silicone scar gels and sheetsWhen the specialist service recommending the treatment is funded by the NHS and has provided NHS funded care for that patient AND • The treatment is for hypertrophic or keloid scars that result from burns, trauma, keloid formation, or surgery and only when one or more of the following clinical criteria are met: a). Scar is functionally disabling b). Scar results in facial disfigurementGreen Specialist Initiation
Silk GarmentFor treating skin conditions i.e. eczema, atopic dermatitisDo not prescribeWY ICS APC November 2022
SimeprevirHepatitis C (commissioned by NHS England)Red
SimeticoneOesophageal cancer in palliative careSpecialist RecommendationWY ICS APC November 2022
SimeticoneFor all other indicationsDo not prescribeWY ICS APC November 2022
Siponimod
Multiple sclerosis (MS) (commissioned by NHS England)
Red
SirolimusProphylaxis of organ rejection in transplant patientsAmber
Sirolimus (Oral)For cardiac rhabdomyoma in neonates and paediatricsRedWY ICS APC November 2022
Sirolimus TopicalFor treatment of angiofibroma’s associated with tuberous sclerosis for adults and children (0.1% and 0.5% strengths). Also, for the treatment of venous malformations in adults and children (0.5% strength only). Only for use in line with local formulary/NICE TAs; and where funded/NHSE commissioned – Seek specialist adviceRedWY ICS APC March 2023 (n)
Sitagliptin Type 2 diabetes (T2DM)Green
Sodium benzoateUrea cycle disordersRed
Sodium bicarbonate capsulesHyperacidity dyspepsia and symptomatic relief of heartburn and peptic ulcerationSpecialist RecommendationWY ICS APC November 2022
Sodium Bicarbonate (Sodium Hydrogen Carbonate) GR capsules (Nephrotrans)2nd line as an option after immediate release sodium bicarbonate capsules. For the treatment of metabolic acidosis and for the maintenance treatment against recurrence of metabolic acidosis in adults with chronic renal impairment.Specialist InitiationWY ICS APC Jan 2024
Sodium chloride 3% medical deviceFor paediatric cystic fibrosisSpecialist RecommendationWY ICS APC Nov 2023
Sodium chloride 6% + 7% inhalation solution 4ml vials (all strengths)For patients with retained bronchopulmonary secretions and where usual treatment is not sufficiently effectiveSpecialist RecommendationWY ICS APC Nov 2023
Sodium clodronate (IV)Bisphosphonate – osteolytic lesions, hypercalcaemia and bone pain associated with skeletal masses in breast cancer or multiple myelomaRed
Sodium hyaluronate (Cystistat®)Interstitial cystitisRed
Sodium oxybateNarcolepsy with cataplexy in childrenRed
Sodium phenylbutyrateUrea cycle disordersRed
Sodium zirconium cyclosilicateFor acute management of hyperkalamia as per NICE TA599RedWY ICS APC 24th May 2023
Sodium zirconium cyclosilicateFor management of hyperkalaemia in dialysis patients as per NICE TA599 updateSpecialist InitiationWY ICS APC 24th May 2023
SofosbuvirHepatitis C (commissioned by NHS England)Red
Sofosbuvir/ledipasvir (Harvoni®)Hepatitis C (commissioned by NHS England)Red
Sofosbuvir/velpatasvir Hepatitis C (commissioned by NHS England)Red
SolriamfetolFor treating excessive daytime sleepiness caused by narcolepsy NICE TA758RedWY ICS APC November 2022
SomatrogonFor treating growth disturbance in children and young people aged 3 and over.Specialist Initiation with additional guidanceWY ICS APC January 2024
Somatropin for adultsAcquired adult-onset post-surgery growth hormone deficiency
*Please note that Omnitrope® is what we commission in adults as growth hormone product of choice*
Amber
Somatropin for paediatricsFor the treatment of Growth
Hormone Insufficiency in Paediatrics
Green Specialist Initiation
SWYAPC
30th September 2020 (n)
SorafenibTreatment of cancersRed
SotorasibFor previously treat KRAS G12C mutation-positive advanced non-small cell lung cancer NICE TA781RedWY ICS APC September 2022
SotrovimabA dual-action nMAB that both blocks viral entry into healthy cells and clears cells infected with SARS-CoV-2RedWY ICS APC Chair's action January 2022.
SpectinomycinUsed as an antibiotic for the treatment of gonorrhoea infectionsRed
St Mark's solutionFor use in the management of short bowel syndrome to maintain an adequate fluid balance and minimise stool output. The unlicensed produce should not be prescribed and should be prepared at home as per the following link. St Mark's solutionDo Not PrescribeWY ICS APC Nov 2023
StavudineHIV infection (commissioned by NHS England)Discontinued NICE guidance - Sept 2020
StiripentolRare forms of epilepsyRed
StreptomycinTreatment of TBRed
Strimvelis®Adenosine deaminase deficiency-severe combined immundeficiencyRed
Subcutaneous (SC) human normal immunoglobulinsAll indicationsRed4th Sept 2020
Subgam®All indicationsRed
Sucroferric oxyhydroxideControl of serum phosphorus levels in dialysis patientsRed
SugammadexReversal of neuromuscular blockade induced by rocuronium or vecuroniumRed
SucralfateAll indications Red
SufentanilManagement of acute moderate to severe pain in adultsDo not Prescribe/Not yet ClassifiedWY ICS APC Jan 2024
Sulcralfate oral (tablets, liquids)Licensed indications for an unlicensed product - benign gastric ulceration, benign duodenal ulcertions, chronic gastritis, prophylaxis of stress ulceration in child under intensive care and prophylaxis of stress ulceration.Specialist RecommendationWY ICS APC November 2022
SulfasalazineLicensed indication - rheumatoid arthritis (RA).
Off-label - other inflammatory arthritides
Amber
SulfasalazinePaediatric rheumatologyAmber
SunitinibTreatment of cancersRed
Susoctocog alfaHaemophilia A
Red
Tacrolimus (oral)Immunosuppressant for transplant patients Amber
Tacrolimus Post paediatric renal transplant Amber
Tacrolimus (Adoport®)Treatment of Crohns Disease unresponsive to other immunosuppressants (off-label use) LTHTUnder review
Tacrolimus Nephrotic Syndrome in children Amber
Tacrolimus suppositoriesActive proctitisRed22nd January 2020
Tacrolimus (topical) Treatment of moderate to severe atopic dermatitis in adults who are not adequately responsive to or are intolerant of conventional therapies such as topical corticosteroids Green
Tacrolimus (Topical) 0.1% ointment and mouthwash made from 1mg capsulesFor the treatment of oral lichen planus and similar immune-inflammatory oral mucosal disease (off-licence). Patients should be counselled on how to make up the mouthwash. Prescribers will communicate the dose/indication clearly to the GP practice.Specialist RecommendationWY ICS APC March 2023
TadalafilPenile rehabilitation post radical prostatectomy or radiotherapyBlack
Tadalafil once daily Erectile dysfunction GreenICS APC September 2021
TadalafilPulmonary arterial hypertensionRed
Tafamidis For treating wild-type or hereditary transthyretin amyloidosis with cardiomyopathy (ATTR CM) in adults Red for existing patients. Do not prescribe for new patients8th September 2021
TafasitamabIndicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem cell transplant (ASCT) in combination with lenalidomide or as monotherapy NICE TA883.
Do Not PrescribeWY ICS APC Nov 2023
TafluprostGlaucomaGreen Specialist Initiation
Taliglucerase alfa Gaucher's disease Red
Talimogene laherparepvec
Treatment of cancersRed
Tamsulosin/solifenacinIndicated for the treatment of moderate to severe storage symptoms (urgency, increased micturition frequency) and voiding symptoms associated with benign prostatic hyperplasia (BPH) in men who are not adequately responding to treatment with monotherapy. Please note tamsulosin and solifenacin may still be prescribed separately.Do not prescribeWY ICS APC Sept 2023
Tapentadol modified-release tabletsChronic non-malignant painGreen Specialist Initiation
TaurineCystic fibrosis (CF) managementAmber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
TB drugsRed when used for TB (except levofloxacin, ofloxacin, co-amoxiclav and clarithromysin)Red
TeduglutideFor treating short bowel syndrome NICE TA804RedICS APC November 2022
Tegafur with uracilTreatment of cancersRed
TelaprevirHepatitis C (commissioned by NHS England)Red
TemozolomideTreatment of cancers; endocrinology; non-malignant conditionsRed
TemsirolimusTreatment of cancersRed
Tenofovir alafenamide Hepatitis B (commissioned by NHS England)Red
Tenofovir HIV infection/hepatits B (commissioned by NHS England)
Red
Tenofovir alafenamide/cobicistat/elvitegravir/emtricitabineHIV infection (commissioned by NHS England)Red
Tenofovir disoproxil/cobicistat/elvitegravir/emtricitabineHIV infection (commissioned by NHS England)Red
Tenofovir/efavirenz/emtricitabineHIV infection (commissioned by NHS England)Red
Tenofovor/emtricitabine/rilpiverineHIV infection (commissioned by NHS England)Red
Tepotinib hydrochloride hydrateIndicated for the treatment of adult patients with advanced non-small cell lung cancer NICE TA789RedICS APC November 2022
Teriflunomide (Aubagio)Treatment of adult and paediatric patients aged 10 years and older with relapsing remitting multiple sclerosis (MS) as per NICE TA303.RedWY ICS APC 24th May 2023
TeriparatideAll indicationsRed
Testosterone gelsHypogonadism due to testosterone deficiency in menGreen Specialist Initiation
Testosterone transdermalFor menopausal women with low sexual desire if HRT alone is not effective (licensed medicines unlicensed use)Specialist RecommendationICS APC September 2021 (n)
TetrahydrobiopterinPhenylketonuriaRed
TezepelumabFor treating severe asthma.RedWY ICS APC July 2023
ThalidomideAll indicationsRed
Thalidomide capsulesFor resistant, recurrent major aphthous stomatitisRedICS APC Chair's action 2022.
ThiotepaAs conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation Red22nd September 2021 (n)
Thrombomodulin recombinant HumanFor treating pulmonary hypertension and pseudoaneurysmRedWY ICS APC 24th May 2023
TicagrelorFor preventing atherothrombotic events after myocardial infarction or with acute coronary syndrome. For use as antiplatelet therapy for percutaneous coronary intervention (PCI)Specialist InitiationWY ICS APC Nov 2023 (a)
Ticagrelor 60mgThe recommendation to switch to 60mg can be made in the original eDAN at discharge post MI or via the A&G route i.e. without a patient needing direct contact with the specialistSpecialist RecommendationWY ICS APC Nov 2023
Tick-bourne encephalitis vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
TildrakizumabPlaque psoriasis in adultsRed20th September 2019 (n)
Timolol/brinzolamide eye erops (Azarga®)GlaucomaGreen Specialist Initiation
TioguanineTreatment of cancersRed
TioproninManagement of Cystinuria (prophylactic/reducing agent). Unlicensed medicine.RedWY ICS APC July 2023.
TipranavirHIV infectionRed
TirbanibulinFor actinic keratosis (Olsen grade 1) of the face or scalp in adults.GreenWY ICS APC 24th May 2023
Tirzepatide Injection 2.5mg & 5mgFor type 2 diabetes in line with NICE TA924Green RestrictedWY ICS Jan 2024
Tirzepatide with insulinFor type 2 diabetes in line with SmPCSpecialist RecommendationWY ICS APC Jan 2024
Tirzepatide doses above 5mgFor type 2 diabetes in line with NICE TA924Specialist RecommendationWY ICS APC Jan 2024
Tirzepatide for all strengthsFor weight managementDo not PrescribeWY ICS APC Jan 2024
Tisagenlecleucel
Treatment of cancer (commissioned by NHS England)
Red
TivozanibCancerRed
TixagevimabFor preventing COVID-19 (with cilgavimab) NICE TA900Do Not PrescribeWY ICS APC Nov 2023
TizanidineSpasticityGreen Specialist Initiation
TizanidineCerebral Palsy Spasticity in ChildrenGreen Specialist Initiation
See LTHT guidance for information
TobramycinFor corneal ulcers and keratitis under microbiology directionRedICS APC September 2022
Tobramycin (Tobi®) nebuliser solutionCystic fibrosis (CF) managementAmber
Tobramycin dry powder inhalerSuppression of chronic pulmonary infections in cystic fibrosisRed
TocilizumabAll indicationsRed
TofacitinibPaediatric indications (where adult NICE TA available)
Red
TofacitinibFor ulcerative colitis NICE TA547RedICS APC November 2022
TofacitinibFor juvenile idiopathic arthritis NICE TA735 (for this indication)RedICS APC April 2022
TofacitinibWith or without methotrexate for moderate to severe active rheumatoid arthritis (RA) in adults according to NICE TA480. Also for active psoriatic arthritis in adults according to NICE TA543 in combination with methotrexateRed
TofacitinibFor all indicationsRedWY ICS APC Jan 2024
TolvaptanHyponatraemia secondary to secretion of inappropriate antidiuretic hormone secretion (SIADH)Red
TopiramatePaediatric MigraineGreen Specialist Initiation
See LTHT guidance for information
TopotecanCancer chemotherapyRed
ToremifeneMetastatic breast cancerGreen Specialist Initiation
Touchcare nanoType 1 diabetes, pregnancy type 1 and 2 diabetes and other commissioned types of diabetes as described in theWY ICS Commissioning StatementRedChair's Action ICS APC May 2023
TrabectedinTreatment of cancersRed
TraLife® oral sprayOral hygeineRed
TrametinibTreatment of cancersRed
TrametinibFor histiocytic disordersRedWY ICS APC April 2022
Tranexamic Acid Injection (procedure related use)For controlling latrogenic bleeding during flexible bronchoscopy. The oral form is classified as GreenRedWY ICS APC Nov 2023
Tranexamic Acid OralFor menorrhagia or local fibrinolysis or hereditary angioedema or epistaxis. The injection is classified as red.GreenWY ICS APC Nov 2023
Trastuzumab deruxtecanTreating HER2-positive unresectable or metastatic breast cancerRed28th July 2021 (n)
TrastuzumabTreatment of cancers
Red
Trastuzumab deruxtecanFor HER2-positive unresectable or metastatic breast cancer after 2 or more anti-HER2 therapies NICE TA704RedICS APC April 2022
Trastuzumab emtansineTreatment of cancersRed
Travel vaccinesFor travel useBlack
NHSE items that should not be routinely prescribed in Primary Care
Travoprost/timolol
(Duotrav®)
Rasied intra-ocular pressureGreen Specialist Initiation
Trazodone hydrochlorideAn antidepressant used for depression and anxietyGreenWY ICS APC Jan 2024
TreosulfanTreatment of cancersRed
Treprostinil sodiumFor pulmonary arterial hypertension. NHSE do not routinely commission for new patientsDo not prescribeWY ICS APC 24th May 2023
Tretinoin (oral)Antineoplastic; induction of remission in acute promyelocytic leukaemiaRed
Triamcinolone acetonide 40mg (Kenalog)For treatment of Hayfever (ULM)Do not prescribeICS APC November 2022
Triamcinolone hexacetonide (Lederspan®)Unlicensed - depot steroid injection for use in childrenRed
TrientineWilson's diseaseRed
Trifluridine/tipiracilTreatment of cancersRed
TrimipramineFor all indicationsBlack for new patients
NHSE items that should not be routinely prescribed in Primary Care
TriptorelinEndometriosis or uterine fibroidsAmber - see GnRH analogues
TriptorelinPrecocious pubertyAmber - SCG not available. Please see Amber classification definition for further information and seek advice from requesting consultant for monitoring requirements.
Triptorelin Management of prostate cancerAmber - see GnRH analogues
Trospium MR Urinary incontinence Green
Trospium XL Urinary incontinence Green
TrussesSurgical appliance for hernia patientsDo not prescribeICS APC November 2022
TryptophanSevere disabling depression. Unlicensed product - named patient use onlyRed
TucatinibUse in combination with trastuzumab and capecitabine for the treatment of adults with HER2-positive locally advanced or metastatic breast cancer NICE TA786RedICS APC November 2022
Turotocog alfaHaemophilia ARed
Ulipristal 5mg1. Pre-operative management of uterine fibroids. Alternative treatment to hysterectomy, myomectomy, uterine embolization or GnRH agonists in perimenopausal patients with moderate to severe symptoms caused by fibroids. Also considered in younger patients with high surgical/anaesthetic risks.
2. Intermittent treatment of moderate to severe symptoms of uterine fibroids
SuspendedMHRA Safety Alert March 2020
Ultibro Breezhaler®Chronic obstructive pulmonary disease (COPD) Green
Uridine TriacetateTreatment of Toxixity with 5-FU and capecitabineRed4th Sept 2020
UpadacitinibFor moderate rheumatoid arthritis NICE TA744RedICS APC April 2022
UpadactinibFor treating active psoriatic arthritis after inadequate response to DMARDS NICE TA768RedWY ICS APC 22nd June 2022
Upadacitinib M/R tabletsLicensed for the treatment of moderate to severe atopic dermatitisRedICS APC March 2022 (n)
Upadacitinib tabletsFor the treatment of severe rheumatoid arthritis (RA) NICE TA665, TA744 & T768RedICS APC September 2022
UrofollitropinIVF treatmentRed
UroshieldFor preventing catheter - associated urinary tract infectionsDo not prescribe/not yet classifiedICS APC November 2022
UstekinumabAll indicationsRed
ValaciclovirFor the treatment of Herpes Simplex Virus (HSV) Encephalitis in PaediatricsGreen Specialist Initiation
See LTHT guidance for information
ValganciclovirAll indicationsRed
Valproate All indications Green Specialist Initiation
VandetanibThyroid cancerRed
VardenafilPenile rehabilitation post radical prostatectomy or radiotherapyBlack
VedolizumabAll indicationsRedWY ICS APC Jan 2024
Velaglucerase alfaGaucher's diseaseRed
VemurafenibMelanomaRed
VenetoclaxCancerRed
VenetoclaxIn combination with rituximab for the treatment of adult patients with chronic lymphocytic leukaemia who have received at least one prior therapyRed
Venetoclax with azactidineFor untreated actute myeloid leukaemia in adults with intensive chemotherapy is unsuitable NICE TA765RedICS APC April 2022
Venlafaxine (at doses over 300mg daily)Treatment of major depressive episodes.
For prevention of recurrence of major depressive episodes.
Treatment of generalised anxiety disorder.
Treatment of social anxiety disorder.
Treatment of panic disorder, with or without agoraphobia
Green Specialist InitiationUpdated 17.02.2020
VerteporfinAge related macular degenerationRed
VibropulseCellulitis, venous leg ulcers and lower limb oedemaBlack22nd January 2020 (n)
Viekirax®Hepatitis C (commissioned by NHS England)Red
Vigam®All indicationsRed
Vildagliptin Type 2 diabetes (T2DM)Green
Vildagliptin with metformin Type 2 diabetes (T2DM) Green
VinblastineTreatment of cancersRed
VincristineTreatment of cancersRed
VinorelbineTreatment of cancersRed
VismodegibTreatment of cancersRed
Vitamin ARetinosa pigmentosaRed
Vivaglobin®All indicationsRed
VoclosporinFor treating lupus nephritis (with immunosuppressives).RedWY ICS APC July 2023.
Volanesorsen
Familial chylomicronemia syndrome (commissioned by NHS England)
Red
Von Willebrand factor, recombinant
Von Willebrand deficiencyRed
Vonicog alfa injection
Von Willebrand deficiency (commissioned by NHS England)
RedICS APC March 2022 (n)
Voretigene neparvovec
Inherited retinal dystrophies (commissioned by NHS England)
Red
VoriconazoleFungal infections. Chronic pulmonary aspergillosisRed
Voriconazole eye dropsCandida keratitisRed29th July 2020 (n)
VortioxetineFor treating major depressive episodesSpecialist InitiationWY ICS APC Jan 2024
Voxelotor
Sickle cell disease (commissioned by NHS England)
Red
VutrisiranFor treating hereditary transthyretin-related amyloidosis as per NICE TA868RedWY ICS APC 24th May 2023
Yellow fever vaccine For travel use Black
NHSE items that should not be routinely prescribed in Primary Care
ZalepionA hypnotic Z-drug for insomnia (short-term use) 4 weeks or lessGreenWY ICS APC Jan 2024
ZanubrutinibFor relapsed or refractory Waldenstrom's MacroglobulinemiaRedICS APC April 2022
ZanubrutinibFor treating chronic lymphocytic leukaemiaRedWY ICS APC Jan 2024
ZiconotideNon-opioid analgesic administered by intrathecal infusionRed
ZidovudineHIV infection (commissioned by NHS England)Red
Zidovudine/lamivudineHIV infection (commissioned by NHS England)Red
Zidovudine/lamivudine/abacavirHIV infection (commissioned by NHS England)Red
Zoledronic acidPrevention of skeletal related events (pathological, spinal compression, radiation/surgery to bone, or tumour-induced hypercalcaemia) in patients with advanced malignancies involving bone; treatment of tomour-induced hypercalcaemiaRed
Zolpidem tartrateA hypnotic Z-drug for insomnia (short-term use) 4 weeks or lessGreenWY ICS APC Jan 2024
ZopicioneA hypnotic Z-drug for insomnia (short-term use) 4 weeks or lessGreenWY ICS APC Jan 2024